ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	173/1067	423/7206	8.19031807665e-42
ko04724	Glutamatergic synapse	87/1067	152/7206	1.6705826508e-34
ko05033	Nicotine addiction	49/1067	56/7206	7.02832127766e-34
ko05032	Morphine addiction	68/1067	110/7206	5.3434533375e-30
ko04727	GABAergic synapse	66/1067	110/7206	4.82070762646e-28
ko04713	Circadian entrainment	70/1067	136/7206	3.62710678763e-24
ko04728	Dopaminergic synapse	80/1067	185/7206	3.06178655004e-21
ko04723	Retrograde endocannabinoid signaling	76/1067	175/7206	2.31737574727e-20
ko04725	Cholinergic synapse	71/1067	160/7206	9.83838217619e-20
ko04721	Synaptic vesicle cycle	46/1067	80/7206	7.92362814992e-19
ko04744	Phototransduction	26/1067	36/7206	1.17724304266e-14
ko04726	Serotonergic synapse	56/1067	137/7206	6.41447734314e-14
ko04024	cAMP signaling pathway	89/1067	279/7206	1.84775901249e-13
ko04742	Taste transduction	33/1067	61/7206	7.77380712326e-13
ko04911	Insulin secretion	49/1067	117/7206	8.22563355197e-13
ko04921	Oxytocin signaling pathway	69/1067	209/7206	1.65614611943e-11
ko04020	Calcium signaling pathway	81/1067	265/7206	2.52256438789e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1067	205/7206	7.95320318995e-11
ko05031	Amphetamine addiction	38/1067	91/7206	3.49158724358e-10
ko03040	Spliceosome	1/1067	145/7206	3.63365316494e-09
ko04720	Long-term potentiation	38/1067	99/7206	6.0820068748e-09
ko04970	Salivary secretion	36/1067	95/7206	2.27105862335e-08
ko05030	Cocaine addiction	30/1067	73/7206	3.96155931435e-08
ko04925	Aldosterone synthesis and secretion	37/1067	105/7206	1.7623410505e-07
ko05203	Viral carcinogenesis	14/1067	277/7206	2.55123900876e-07
ko04010	MAPK signaling pathway	81/1067	321/7206	4.91606056407e-07
ko04060	Cytokine-cytokine receptor interaction	7/1067	191/7206	7.63813183762e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1067	74/7206	8.61348746598e-07
ko05322	Systemic lupus erythematosus	5/1067	151/7206	6.99622218434e-06
ko04514	Cell adhesion molecules (CAMs)	39/1067	130/7206	8.03184462084e-06
ko04971	Gastric acid secretion	32/1067	98/7206	8.59948612494e-06
ko04072	Phospholipase D signaling pathway	53/1067	197/7206	8.88047772464e-06
ko04972	Pancreatic secretion	35/1067	111/7206	8.98594874334e-06
ko04070	Phosphatidylinositol signaling system	35/1067	112/7206	9.91901334295e-06
ko04740	Olfactory transduction	27/1067	80/7206	1.89137473745e-05
ko03013	RNA transport	7/1067	166/7206	1.93181711964e-05
ko05168	Herpes simplex infection	9/1067	182/7206	3.06157928931e-05
ko04360	Axon guidance	58/1067	233/7206	4.56193927064e-05
ko05164	Influenza A	8/1067	167/7206	5.73951870417e-05
ko04022	cGMP-PKG signaling pathway	53/1067	216/7206	0.000129335479703
ko04730	Long-term depression	25/1067	78/7206	0.00013946220043
ko04260	Cardiac muscle contraction	29/1067	98/7206	0.000148239962319
ko04621	NOD-like receptor signaling pathway	8/1067	157/7206	0.000154544168791
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1067	79/7206	0.000155430671885
ko05205	Proteoglycans in cancer	20/1067	271/7206	0.000226249804393
ko04141	Protein processing in endoplasmic reticulum	11/1067	184/7206	0.000300652120167
ko05169	Epstein-Barr virus infection	14/1067	206/7206	0.00046217222217
ko03008	Ribosome biogenesis in eukaryotes	2/1067	79/7206	0.000629924548487
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1067	59/7206	0.000642409430088
ko04966	Collecting duct acid secretion	11/1067	26/7206	0.000646035853465
ko04612	Antigen processing and presentation	2/1067	77/7206	0.000957309998104
ko04540	Gap junction	33/1067	128/7206	0.000978794730367
ko05414	Dilated cardiomyopathy	30/1067	112/7206	0.0010739529372
ko04976	Bile secretion	23/1067	80/7206	0.00123743902051
ko04120	Ubiquitin mediated proteolysis	8/1067	138/7206	0.00147868221224
ko04915	Estrogen signaling pathway	33/1067	131/7206	0.00169199768756
ko05110	Vibrio cholerae infection	19/1067	63/7206	0.00186112942318
ko04110	Cell cycle	9/1067	145/7206	0.00194663560836
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1067	182/7206	0.00203709100842
ko04745	Phototransduction - fly	13/1067	38/7206	0.00224488549733
ko00480	Glutathione metabolism	1/1067	55/7206	0.00333900799021
ko04146	Peroxisome	4/1067	89/7206	0.00378339175194
ko05162	Measles	7/1067	120/7206	0.00392517986074
ko00240	Pyrimidine metabolism	6/1067	110/7206	0.00401601870896
ko04640	Hematopoietic cell lineage	2/1067	64/7206	0.0041918470791
ko05161	Hepatitis B	13/1067	173/7206	0.00462182486335
ko05140	Leishmaniasis	3/1067	75/7206	0.00487207569274
ko04140	Autophagy - animal	12/1067	164/7206	0.00509628993922
ko03018	RNA degradation	4/1067	84/7206	0.00521921825882
ko04064	NF-kappa B signaling pathway	5/1067	96/7206	0.00541862212948
ko04630	Jak-STAT signaling pathway	9/1067	132/7206	0.00631872359913
ko04964	Proximal tubule bicarbonate reclamation	10/1067	29/7206	0.00665652962009
ko04924	Renin secretion	22/1067	86/7206	0.00854263450881
ko04918	Thyroid hormone synthesis	22/1067	86/7206	0.00854263450881
ko04014	Ras signaling pathway	57/1067	279/7206	0.00966277558527
ko05144	Malaria	1/1067	45/7206	0.0105862264432
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1067	14/7206	0.0107496840148
ko03420	Nucleotide excision repair	1/1067	46/7206	0.0107715200313
ko05145	Toxoplasmosis	9/1067	126/7206	0.0111815829943
ko05321	Inflammatory bowel disease (IBD)	2/1067	56/7206	0.0129078737494
ko04658	Th1 and Th2 cell differentiation	6/1067	96/7206	0.0135727555846
ko04217	Necroptosis	15/1067	178/7206	0.0136121577163
ko04657	IL-17 signaling pathway	5/1067	87/7206	0.0141931717577
ko05133	Pertussis	5/1067	87/7206	0.0141931717577
ko04750	Inflammatory mediator regulation of TRP channels	28/1067	122/7206	0.0142781509649
ko03022	Basal transcription factors	1/1067	44/7206	0.0165352819792
ko04115	p53 signaling pathway	4/1067	74/7206	0.0200097091752
ko05215	Prostate cancer	8/1067	111/7206	0.0213367219827
ko05418	Fluid shear stress and atherosclerosis	15/1067	173/7206	0.0222079409943
ko04923	Regulation of lipolysis in adipocytes	19/1067	77/7206	0.0223314601326
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1067	40/7206	0.0235359474643
ko04062	Chemokine signaling pathway	41/1067	201/7206	0.0267392505062
ko05166	HTLV-I infection	30/1067	292/7206	0.0282972423729
ko04622	RIG-I-like receptor signaling pathway	3/1067	62/7206	0.0288150201138
ko04930	Type II diabetes mellitus	14/1067	54/7206	0.031822061348
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1067	100/7206	0.0319063553299
ko05016	Huntington's disease	21/1067	215/7206	0.0320953213303
ko04711	Circadian rhythm - fly	5/1067	13/7206	0.0323481883105
ko04510	Focal adhesion	24/1067	240/7206	0.0331687121513
ko00982	Drug metabolism - cytochrome P450	1/1067	37/7206	0.034757088861
ko00630	Glyoxylate and dicarboxylate metabolism	1/1067	38/7206	0.0356524166747
ko05231	Choline metabolism in cancer	29/1067	134/7206	0.03570709635
ko00270	Cysteine and methionine metabolism	2/1067	47/7206	0.0383541656016
ko03320	PPAR signaling pathway	4/1067	69/7206	0.038749763189
ko00260	Glycine, serine and threonine metabolism	2/1067	48/7206	0.0388907612011
ko05219	Bladder cancer	2/1067	48/7206	0.0388907612011
ko05012	Parkinson's disease	14/1067	155/7206	0.0394575929737
ko04371	Apelin signaling pathway	36/1067	177/7206	0.0414048730204
ko04210	Apoptosis	17/1067	180/7206	0.0428034668242
ko04960	Aldosterone-regulated sodium reabsorption	11/1067	41/7206	0.0434748153323
ko04973	Carbohydrate digestion and absorption	11/1067	42/7206	0.0478151024197
ko04350	TGF-beta signaling pathway	8/1067	103/7206	0.0489325906503