ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 49/487 191/7206 7.16847634009e-17 ko04621 NOD-like receptor signaling pathway 43/487 157/7206 4.77113674838e-16 ko05164 Influenza A 41/487 167/7206 1.40133308918e-13 ko04380 Osteoclast differentiation 36/487 134/7206 2.46467390596e-13 ko04650 Natural killer cell mediated cytotoxicity 29/487 97/7206 3.01052917539e-12 ko04217 Necroptosis 40/487 178/7206 6.0427491937e-12 ko05162 Measles 32/487 120/7206 6.85842588455e-12 ko04064 NF-kappa B signaling pathway 28/487 96/7206 1.4034901471e-11 ko05340 Primary immunodeficiency 15/487 30/7206 1.36964514403e-10 ko05145 Toxoplasmosis 31/487 126/7206 1.39893841332e-10 ko05321 Inflammatory bowel disease (IBD) 20/487 56/7206 2.15387712397e-10 ko04620 Toll-like receptor signaling pathway 27/487 100/7206 2.32049469113e-10 ko05140 Leishmaniasis 23/487 75/7206 3.19375856758e-10 ko05332 Graft-versus-host disease 11/487 18/7206 2.48230559974e-09 ko04659 Th17 cell differentiation 26/487 106/7206 4.77606241543e-09 ko05330 Allograft rejection 12/487 24/7206 1.01736615295e-08 ko04612 Antigen processing and presentation 21/487 77/7206 1.9839202708e-08 ko05152 Tuberculosis 35/487 187/7206 2.30399858295e-08 ko05168 Herpes simplex infection 34/487 182/7206 3.8672554241e-08 ko04622 RIG-I-like receptor signaling pathway 18/487 62/7206 7.20624414273e-08 ko05150 Staphylococcus aureus infection 13/487 36/7206 2.86449967813e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/487 191/7206 4.18799026441e-07 ko04630 Jak-STAT signaling pathway 26/487 132/7206 5.51867162634e-07 ko04660 T cell receptor signaling pathway 25/487 124/7206 5.76848512765e-07 ko05320 Autoimmune thyroid disease 11/487 29/7206 1.36008613273e-06 ko04623 Cytosolic DNA-sensing pathway 13/487 41/7206 1.5960068097e-06 ko04672 Intestinal immune network for IgA production 12/487 37/7206 3.09079868689e-06 ko05133 Pertussis 19/487 87/7206 3.84591086852e-06 ko04940 Type I diabetes mellitus 11/487 32/7206 4.20985290967e-06 ko04658 Th1 and Th2 cell differentiation 20/487 96/7206 4.63411153148e-06 ko05323 Rheumatoid arthritis 19/487 89/7206 5.49230790385e-06 ko04062 Chemokine signaling pathway 31/487 201/7206 1.16253924805e-05 ko05142 Chagas disease (American trypanosomiasis) 23/487 130/7206 1.63491340554e-05 ko04640 Hematopoietic cell lineage 15/487 64/7206 1.64410633469e-05 ko05161 Hepatitis B 28/487 173/7206 1.64608948526e-05 ko00120 Primary bile acid biosynthesis 8/487 20/7206 2.50616671895e-05 ko05144 Malaria 12/487 45/7206 2.91475670617e-05 ko04668 TNF signaling pathway 21/487 120/7206 4.50206052647e-05 ko05310 Asthma 7/487 17/7206 6.60976253124e-05 ko04662 B cell receptor signaling pathway 17/487 88/7206 6.6503524576e-05 ko04210 Apoptosis 26/487 180/7206 0.000212968034575 ko04610 Complement and coagulation cascades 15/487 79/7206 0.00021659593616 ko05160 Hepatitis C 23/487 153/7206 0.000242378557602 ko04390 Hippo signaling pathway 2/487 188/7206 0.000324296614419 ko04310 Wnt signaling pathway 2/487 181/7206 0.000467735370953 ko05034 Alcoholism 4/487 238/7206 0.000517025028768 ko03040 Spliceosome 1/487 145/7206 0.00067914594367 ko04137 Mitophagy - animal 14/487 82/7206 0.00106397554283 ko04664 Fc epsilon RI signaling pathway 13/487 77/7206 0.00176620219728 ko04657 IL-17 signaling pathway 14/487 87/7206 0.00191822857842 ko04360 Axon guidance 5/487 233/7206 0.00205677183222 ko03010 Ribosome 1/487 129/7206 0.00215565526555 ko00590 Arachidonic acid metabolism 10/487 52/7206 0.00217653171168 ko04611 Platelet activation 22/487 163/7206 0.00218418288582 ko03050 Proteasome 10/487 54/7206 0.00291596704657 ko05132 Salmonella infection 15/487 98/7206 0.00324124875497 ko05146 Amoebiasis 15/487 99/7206 0.00341316223674 ko05134 Legionellosis 12/487 74/7206 0.0037034954629 ko04142 Lysosome 20/487 151/7206 0.00446094299731 ko04666 Fc gamma R-mediated phagocytosis 17/487 122/7206 0.00510568679586 ko00140 Steroid hormone biosynthesis 8/487 41/7206 0.00540148827168 ko04916 Melanogenesis 2/487 142/7206 0.00599595849307 ko00051 Fructose and mannose metabolism 8/487 42/7206 0.00628830722215 ko00592 alpha-Linolenic acid metabolism 5/487 19/7206 0.00726486713997 ko05418 Fluid shear stress and atherosclerosis 21/487 173/7206 0.00828358022323 ko04080 Neuroactive ligand-receptor interaction 16/487 423/7206 0.00928531788145 ko04530 Tight junction 6/487 228/7206 0.0100035796288 ko04145 Phagosome 20/487 162/7206 0.0100198987494 ko04723 Retrograde endocannabinoid signaling 4/487 175/7206 0.0136225605022 ko00980 Metabolism of xenobiotics by cytochrome P450 7/487 40/7206 0.0163790271193 ko04110 Cell cycle 3/487 145/7206 0.018146386219 ko05143 African trypanosomiasis 6/487 32/7206 0.0185680819889 ko05031 Amphetamine addiction 1/487 91/7206 0.0204271315134 ko04911 Insulin secretion 2/487 117/7206 0.0239733147319 ko05131 Shigellosis 11/487 82/7206 0.024478103551 ko04728 Dopaminergic synapse 5/487 185/7206 0.0246187050252 ko05416 Viral myocarditis 8/487 55/7206 0.0301897156387 ko04111 Cell cycle - yeast 1/487 90/7206 0.0308502754493 ko05169 Epstein-Barr virus infection 22/487 206/7206 0.0330304596854 ko01524 Platinum drug resistance 10/487 76/7206 0.0357370857709 ko00982 Drug metabolism - cytochrome P450 6/487 37/7206 0.0358857786949 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/487 5/7206 0.0397522647987 ko05204 Chemical carcinogenesis 7/487 48/7206 0.0407812358417 ko04068 FoxO signaling pathway 18/487 167/7206 0.042274645559 ko04721 Synaptic vesicle cycle 1/487 80/7206 0.0426790066127 ko05224 Breast cancer 5/487 174/7206 0.0446085455678 ko04020 Calcium signaling pathway 10/487 265/7206 0.0459982889639 ko04917 Prolactin signaling pathway 11/487 87/7206 0.0477793228192