ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 31/251 134/7206 1.05378840661e-17 ko04621 NOD-like receptor signaling pathway 27/251 157/7206 3.24537879202e-12 ko04668 TNF signaling pathway 23/251 120/7206 1.42246147428e-11 ko04060 Cytokine-cytokine receptor interaction 28/251 191/7206 6.71761239122e-11 ko05164 Influenza A 25/251 167/7206 4.79094689867e-10 ko04658 Th1 and Th2 cell differentiation 19/251 96/7206 5.1337473815e-10 ko05161 Hepatitis B 24/251 173/7206 5.24114012231e-09 ko04657 IL-17 signaling pathway 16/251 87/7206 3.77222889268e-08 ko04620 Toll-like receptor signaling pathway 17/251 100/7206 4.75807034974e-08 ko04064 NF-kappa B signaling pathway 16/251 96/7206 1.59190942504e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/251 191/7206 1.63709794601e-07 ko04660 T cell receptor signaling pathway 18/251 124/7206 2.33140144593e-07 ko05145 Toxoplasmosis 18/251 126/7206 2.98484481142e-07 ko04630 Jak-STAT signaling pathway 18/251 132/7206 6.07384960514e-07 ko00643 Styrene degradation 4/251 4/7206 1.43829972101e-06 ko05321 Inflammatory bowel disease (IBD) 11/251 56/7206 2.72925495133e-06 ko04659 Th17 cell differentiation 15/251 106/7206 3.37314045332e-06 ko04210 Apoptosis 20/251 180/7206 3.87195149793e-06 ko05168 Herpes simplex infection 20/251 182/7206 4.59365470956e-06 ko05160 Hepatitis C 18/251 153/7206 5.34166491961e-06 ko04623 Cytosolic DNA-sensing pathway 9/251 41/7206 8.62572916722e-06 ko05140 Leishmaniasis 12/251 75/7206 9.09268018691e-06 ko04662 B cell receptor signaling pathway 13/251 88/7206 9.50827916649e-06 ko05142 Chagas disease (American trypanosomiasis) 15/251 130/7206 4.16205234488e-05 ko05133 Pertussis 12/251 87/7206 4.25831239715e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 15/251 135/7206 6.47960724852e-05 ko05162 Measles 14/251 120/7206 6.65337226672e-05 ko05152 Tuberculosis 18/251 187/7206 8.30948586028e-05 ko04217 Necroptosis 17/251 178/7206 0.000144350173926 ko04917 Prolactin signaling pathway 11/251 87/7206 0.000197490900398 ko04672 Intestinal immune network for IgA production 7/251 37/7206 0.000240505331529 ko05323 Rheumatoid arthritis 11/251 89/7206 0.000242186223323 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/251 92/7206 0.000325095738329 ko05132 Salmonella infection 11/251 98/7206 0.000563721294477 ko00350 Tyrosine metabolism 6/251 33/7206 0.00084406584267 ko04622 RIG-I-like receptor signaling pathway 8/251 62/7206 0.00128506051778 ko04624 Toll and Imd signaling pathway 7/251 49/7206 0.00140580177148 ko05166 HTLV-I infection 21/251 292/7206 0.00153907696417 ko05146 Amoebiasis 10/251 99/7206 0.00224158476495 ko05134 Legionellosis 8/251 74/7206 0.0040033756314 ko04010 MAPK signaling pathway 21/251 321/7206 0.00464373599337 ko04218 Cellular senescence 14/251 177/7206 0.00514624721399 ko04080 Neuroactive ligand-receptor interaction 5/251 423/7206 0.00562333193873 ko04512 ECM-receptor interaction 8/251 79/7206 0.00597220280142 ko04650 Natural killer cell mediated cytotoxicity 9/251 97/7206 0.00645983805418 ko05202 Transcriptional misregulation in cancer 14/251 188/7206 0.00699231155843 ko04068 FoxO signaling pathway 13/251 167/7206 0.00788706227892 ko05418 Fluid shear stress and atherosclerosis 13/251 173/7206 0.00922231423775 ko04930 Type II diabetes mellitus 6/251 54/7206 0.0107154852529 ko01522 Endocrine resistance 10/251 124/7206 0.0110237538665 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/251 182/7206 0.0122826265731 ko00140 Steroid hormone biosynthesis 5/251 41/7206 0.0132595363739 ko04115 p53 signaling pathway 7/251 74/7206 0.014133235839 ko04611 Platelet activation 12/251 163/7206 0.0141691790871 ko04062 Chemokine signaling pathway 14/251 201/7206 0.0164362492302 ko04640 Hematopoietic cell lineage 6/251 64/7206 0.0233614911977 ko05131 Shigellosis 7/251 82/7206 0.0236598096756 ko05212 Pancreatic cancer 7/251 83/7206 0.0251004641032 ko04931 Insulin resistance 10/251 137/7206 0.0283753740173 ko00740 Riboflavin metabolism 2/251 8/7206 0.0294535098241 ko05210 Colorectal cancer 7/251 86/7206 0.0297806361715 ko00120 Primary bile acid biosynthesis 3/251 20/7206 0.0307145844904 ko04723 Retrograde endocannabinoid signaling 1/251 175/7206 0.032886362423 ko00590 Arachidonic acid metabolism 5/251 52/7206 0.0338398755352 ko00401 Novobiocin biosynthesis 1/251 1/7206 0.0348320843742 ko05205 Proteoglycans in cancer 16/251 271/7206 0.0398955040995 ko04915 Estrogen signaling pathway 9/251 131/7206 0.048047805718