ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1163	423/7206	1.7588875971e-52
ko04724	Glutamatergic synapse	91/1163	152/7206	3.84318604961e-35
ko05033	Nicotine addiction	50/1163	56/7206	1.21468279771e-33
ko05032	Morphine addiction	73/1163	110/7206	1.29737711112e-32
ko04727	GABAergic synapse	69/1163	110/7206	1.29497480768e-28
ko04713	Circadian entrainment	78/1163	136/7206	1.86965602704e-28
ko04728	Dopaminergic synapse	88/1163	185/7206	3.70682920751e-24
ko04723	Retrograde endocannabinoid signaling	82/1163	175/7206	4.92329562808e-22
ko04721	Synaptic vesicle cycle	51/1163	80/7206	6.73927200985e-22
ko04725	Cholinergic synapse	77/1163	160/7206	1.2026676296e-21
ko04024	cAMP signaling pathway	107/1163	279/7206	6.13063141218e-20
ko04911	Insulin secretion	59/1163	117/7206	4.40465119621e-18
ko04020	Calcium signaling pathway	97/1163	265/7206	1.84244966301e-16
ko04742	Taste transduction	38/1163	61/7206	3.9196529e-16
ko04744	Phototransduction	28/1163	36/7206	4.04395903441e-16
ko04726	Serotonergic synapse	60/1163	137/7206	1.00155646633e-14
ko04921	Oxytocin signaling pathway	77/1163	209/7206	1.93486164263e-13
ko05031	Amphetamine addiction	44/1163	91/7206	5.66482003805e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1163	205/7206	1.44446544649e-11
ko04720	Long-term potentiation	44/1163	99/7206	2.11062087318e-11
ko04970	Salivary secretion	42/1163	95/7206	7.46648453755e-11
ko03040	Spliceosome	1/1163	145/7206	3.14614465151e-10
ko04740	Olfactory transduction	36/1163	80/7206	9.40685920156e-10
ko04925	Aldosterone synthesis and secretion	42/1163	105/7206	3.20596557571e-09
ko05030	Cocaine addiction	33/1163	73/7206	4.10349155244e-09
ko04971	Gastric acid secretion	39/1163	98/7206	1.39047765998e-08
ko05203	Viral carcinogenesis	14/1163	277/7206	1.42254620043e-08
ko04360	Axon guidance	71/1163	233/7206	3.11829578656e-08
ko05322	Systemic lupus erythematosus	4/1163	151/7206	1.3504943462e-07
ko04022	cGMP-PKG signaling pathway	63/1163	216/7206	1.14679363624e-06
ko04060	Cytokine-cytokine receptor interaction	9/1163	191/7206	1.20807738542e-06
ko03013	RNA transport	7/1163	166/7206	2.88661330831e-06
ko05168	Herpes simplex infection	9/1163	182/7206	5.03309813836e-06
ko04972	Pancreatic secretion	37/1163	111/7206	6.21049205725e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1163	74/7206	7.02462819402e-06
ko05164	Influenza A	8/1163	167/7206	9.19190518054e-06
ko04141	Protein processing in endoplasmic reticulum	10/1163	184/7206	1.03659148275e-05
ko04010	MAPK signaling pathway	82/1163	321/7206	1.17008034328e-05
ko04745	Phototransduction - fly	17/1163	38/7206	2.95132960579e-05
ko04621	NOD-like receptor signaling pathway	8/1163	157/7206	3.74483581764e-05
ko04514	Cell adhesion molecules (CAMs)	39/1163	130/7206	5.85043214938e-05
ko04966	Collecting duct acid secretion	13/1163	26/7206	6.20392317648e-05
ko04070	Phosphatidylinositol signaling system	35/1163	112/7206	7.23069456078e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1163	79/7206	7.50350797971e-05
ko05110	Vibrio cholerae infection	23/1163	63/7206	8.10883634694e-05
ko04750	Inflammatory mediator regulation of TRP channels	37/1163	122/7206	8.79570438458e-05
ko04976	Bile secretion	27/1163	80/7206	9.01540668531e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1163	59/7206	9.55048225105e-05
ko04110	Cell cycle	8/1163	145/7206	0.000139563075319
ko04730	Long-term depression	26/1163	78/7206	0.000149994814851
ko04610	Complement and coagulation cascades	2/1163	79/7206	0.000173497180315
ko03008	Ribosome biogenesis in eukaryotes	2/1163	79/7206	0.000173497180315
ko04072	Phospholipase D signaling pathway	52/1163	197/7206	0.000175550362001
ko04540	Gap junction	37/1163	128/7206	0.000231053554091
ko05162	Measles	6/1163	120/7206	0.000247063183761
ko04612	Antigen processing and presentation	2/1163	77/7206	0.00025762728244
ko04260	Cardiac muscle contraction	30/1163	98/7206	0.000277247810981
ko05414	Dilated cardiomyopathy	33/1163	112/7206	0.000380354585172
ko04120	Ubiquitin mediated proteolysis	8/1163	138/7206	0.000383853400359
ko05169	Epstein-Barr virus infection	16/1163	206/7206	0.000493157630562
ko04924	Renin secretion	27/1163	86/7206	0.00052821761678
ko04014	Ras signaling pathway	67/1163	279/7206	0.000618221277401
ko05205	Proteoglycans in cancer	25/1163	271/7206	0.000992742478825
ko04915	Estrogen signaling pathway	36/1163	131/7206	0.00104928365094
ko00480	Glutathione metabolism	1/1163	55/7206	0.0013332352218
ko04630	Jak-STAT signaling pathway	9/1163	132/7206	0.00179995483175
ko04064	NF-kappa B signaling pathway	5/1163	96/7206	0.00184867497468
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1163	182/7206	0.00211462969892
ko05140	Leishmaniasis	3/1163	75/7206	0.00226136611978
ko05161	Hepatitis B	14/1163	173/7206	0.00230641501422
ko04371	Apelin signaling pathway	44/1163	177/7206	0.00252850224542
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1163	14/7206	0.00337074733881
ko04217	Necroptosis	15/1163	178/7206	0.00364380894729
ko00240	Pyrimidine metabolism	7/1163	110/7206	0.0036587090223
ko03420	Nucleotide excision repair	1/1163	46/7206	0.00447020503764
ko00260	Glycine, serine and threonine metabolism	1/1163	48/7206	0.00467734913048
ko05219	Bladder cancer	1/1163	48/7206	0.00467734913048
ko04658	Th1 and Th2 cell differentiation	6/1163	96/7206	0.00501261670155
ko04657	IL-17 signaling pathway	5/1163	87/7206	0.00502551518459
ko04146	Peroxisome	5/1163	89/7206	0.00522598643963
ko05321	Inflammatory bowel disease (IBD)	2/1163	56/7206	0.00573850213646
ko04015	Rap1 signaling pathway	62/1163	278/7206	0.00595546356115
ko04350	TGF-beta signaling pathway	7/1163	103/7206	0.0066569714003
ko03022	Basal transcription factors	1/1163	44/7206	0.00669336347949
ko05144	Malaria	1/1163	45/7206	0.00685842942424
ko00071	Fatty acid degradation	1/1163	45/7206	0.00685842942424
ko04912	GnRH signaling pathway	31/1163	122/7206	0.00856310121395
ko05215	Prostate cancer	8/1163	111/7206	0.00868211150648
ko04640	Hematopoietic cell lineage	3/1163	64/7206	0.00943470278942
ko05131	Shigellosis	5/1163	82/7206	0.00971120288092
ko00310	Lysine degradation	4/1163	73/7206	0.00974133759772
ko04711	Circadian rhythm - fly	6/1163	13/7206	0.0107525293126
ko04918	Thyroid hormone synthesis	23/1163	86/7206	0.0114034292355
ko04923	Regulation of lipolysis in adipocytes	21/1163	77/7206	0.0119151249805
ko00330	Arginine and proline metabolism	3/1163	61/7206	0.0133390340997
ko04622	RIG-I-like receptor signaling pathway	3/1163	62/7206	0.0137043919085
ko05016	Huntington's disease	22/1163	215/7206	0.0143822188316
ko05166	HTLV-I infection	32/1163	292/7206	0.0145382139554
ko04626	Plant-pathogen interaction	7/1163	18/7206	0.0173210890842
ko04973	Carbohydrate digestion and absorption	13/1163	42/7206	0.0178117780418
ko05133	Pertussis	6/1163	87/7206	0.0178610480289
ko04964	Proximal tubule bicarbonate reclamation	10/1163	29/7206	0.0182071558266
ko01524	Platinum drug resistance	5/1163	76/7206	0.0184368245219
ko00562	Inositol phosphate metabolism	23/1163	89/7206	0.0191781197894
ko04270	Vascular smooth muscle contraction	36/1163	154/7206	0.0193983845206
ko04710	Circadian rhythm	13/1163	43/7206	0.0198159485949
ko05145	Toxoplasmosis	11/1163	126/7206	0.019998792119
ko04210	Apoptosis	18/1163	180/7206	0.0234877389006
ko04140	Autophagy - animal	16/1163	164/7206	0.0237320051808
ko03018	RNA degradation	6/1163	84/7206	0.024041568065
ko04115	p53 signaling pathway	5/1163	74/7206	0.0252971846135
ko04620	Toll-like receptor signaling pathway	8/1163	100/7206	0.0273599253694
ko04916	Melanogenesis	33/1163	142/7206	0.0277604265123
ko04922	Glucagon signaling pathway	30/1163	128/7206	0.02869904391
ko04218	Cellular senescence	18/1163	177/7206	0.02931912121
ko04960	Aldosterone-regulated sodium reabsorption	12/1163	41/7206	0.0311788426215
ko04062	Chemokine signaling pathway	44/1163	201/7206	0.0318041812633
ko00860	Porphyrin and chlorophyll metabolism	1/1163	34/7206	0.0334171068208
ko00500	Starch and sucrose metabolism	1/1163	35/7206	0.0344487433297
ko04214	Apoptosis - fly	5/1163	72/7206	0.0348001859289
ko00280	Valine, leucine and isoleucine degradation	3/1163	54/7206	0.0385312902562
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1163	100/7206	0.0391582809649