ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04020	Calcium signaling pathway	53/493	265/7206	4.57541574299e-13
ko04080	Neuroactive ligand-receptor interaction	57/493	423/7206	4.57930394007e-07
ko04710	Circadian rhythm	13/493	43/7206	3.3506590823e-06
ko04922	Glucagon signaling pathway	23/493	128/7206	1.53327786792e-05
ko04022	cGMP-PKG signaling pathway	32/493	216/7206	2.67037362772e-05
ko04921	Oxytocin signaling pathway	31/493	209/7206	3.59206697001e-05
ko04713	Circadian entrainment	23/493	136/7206	4.20731454075e-05
ko04261	Adrenergic signaling in cardiomyocytes	30/493	205/7206	6.03201722101e-05
ko04925	Aldosterone synthesis and secretion	19/493	105/7206	7.60613971457e-05
ko04971	Gastric acid secretion	18/493	98/7206	9.57453259747e-05
ko04724	Glutamatergic synapse	24/493	152/7206	0.000108593585243
ko04144	Endocytosis	8/493	342/7206	0.000247741951401
ko04270	Vascular smooth muscle contraction	23/493	154/7206	0.000309351716328
ko04152	AMPK signaling pathway	24/493	161/7206	0.000351385606243
ko00010	Glycolysis / Gluconeogenesis	14/493	74/7206	0.000411604783404
ko04970	Salivary secretion	16/493	95/7206	0.000639947286158
ko03040	Spliceosome	1/493	145/7206	0.000682566011006
ko00230	Purine metabolism	26/493	194/7206	0.000792305671368
ko04120	Ubiquitin mediated proteolysis	1/493	138/7206	0.000993933065499
ko00051	Fructose and mannose metabolism	9/493	42/7206	0.00177803816086
ko00710	Carbon fixation in photosynthetic organisms	7/493	27/7206	0.00179149106544
ko03010	Ribosome	1/493	129/7206	0.00219616723909
ko04976	Bile secretion	13/493	80/7206	0.0028016007678
ko04974	Protein digestion and absorption	15/493	96/7206	0.00310770294537
ko04972	Pancreatic secretion	16/493	111/7206	0.00379253816804
ko04070	Phosphatidylinositol signaling system	16/493	112/7206	0.00409447279542
ko03013	RNA transport	3/493	166/7206	0.00475977286496
ko05031	Amphetamine addiction	14/493	91/7206	0.00482175397973
ko01230	Biosynthesis of amino acids	13/493	85/7206	0.0071394722421
ko04260	Cardiac muscle contraction	14/493	98/7206	0.00742765531085
ko04711	Circadian rhythm - fly	4/493	13/7206	0.00941445863193
ko04750	Inflammatory mediator regulation of TRP channels	16/493	122/7206	0.0103102459527
ko05414	Dilated cardiomyopathy	15/493	112/7206	0.0121225462377
ko00250	Alanine, aspartate and glutamate metabolism	7/493	38/7206	0.013263478607
ko04745	Phototransduction - fly	7/493	38/7206	0.013263478607
ko04371	Apelin signaling pathway	21/493	177/7206	0.0144637724164
ko02010	ABC transporters	7/493	39/7206	0.0152414499169
ko04911	Insulin secretion	15/493	117/7206	0.015494028606
ko04110	Cell cycle	3/493	145/7206	0.0183870872098
ko01200	Carbon metabolism	16/493	128/7206	0.0193891452929
ko00140	Steroid hormone biosynthesis	7/493	41/7206	0.019810304108
ko04960	Aldosterone-regulated sodium reabsorption	7/493	41/7206	0.019810304108
ko04730	Long-term depression	11/493	78/7206	0.0202811355535
ko04727	GABAergic synapse	14/493	110/7206	0.0209093808034
ko00220	Arginine biosynthesis	5/493	24/7206	0.021082157882
ko04024	cAMP signaling pathway	29/493	279/7206	0.0211764905734
ko00350	Tyrosine metabolism	6/493	33/7206	0.0226340203883
ko00052	Galactose metabolism	6/493	33/7206	0.0226340203883
ko04720	Long-term potentiation	13/493	99/7206	0.0240138802828
ko05230	Central carbon metabolism in cancer	11/493	81/7206	0.0244231047019
ko05168	Herpes simplex infection	5/493	182/7206	0.0244408224432
ko00360	Phenylalanine metabolism	4/493	17/7206	0.0252108628438
ko00960	Tropane, piperidine and pyridine alkaloid biosynthesis	2/493	4/7206	0.0255484439082
ko00680	Methane metabolism	6/493	34/7206	0.0259500497694
ko05034	Alcoholism	8/493	238/7206	0.0262039180608
ko05203	Viral carcinogenesis	10/493	277/7206	0.0282082327636
ko05220	Chronic myeloid leukemia	1/493	85/7206	0.0294924571856
ko04975	Fat digestion and absorption	6/493	35/7206	0.0295738180541
ko04657	IL-17 signaling pathway	1/493	87/7206	0.0298922294791
ko04614	Renin-angiotensin system	4/493	18/7206	0.0307097185099
ko00620	Pyruvate metabolism	7/493	46/7206	0.0352193244199
ko04510	Focal adhesion	25/493	240/7206	0.0360211110214
ko04725	Cholinergic synapse	18/493	160/7206	0.0372825818021
ko05164	Influenza A	5/493	167/7206	0.0432795086691
ko05410	Hypertrophic cardiomyopathy (HCM)	12/493	100/7206	0.0461741516674