ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	155/1013	423/7206	1.84384250882e-33
ko04724	Glutamatergic synapse	81/1013	152/7206	7.76219212534e-31
ko05033	Nicotine addiction	42/1013	56/7206	6.16871522244e-25
ko05032	Morphine addiction	59/1013	110/7206	6.70386027658e-23
ko04713	Circadian entrainment	66/1013	136/7206	2.68349874354e-22
ko04727	GABAergic synapse	57/1013	110/7206	3.47942096843e-21
ko04728	Dopaminergic synapse	76/1013	185/7206	5.27686150638e-20
ko04721	Synaptic vesicle cycle	45/1013	80/7206	7.75502145939e-19
ko04024	cAMP signaling pathway	94/1013	279/7206	2.59976780639e-17
ko04723	Retrograde endocannabinoid signaling	69/1013	175/7206	4.06451654084e-17
ko04020	Calcium signaling pathway	86/1013	265/7206	7.38158605891e-15
ko04921	Oxytocin signaling pathway	73/1013	209/7206	1.00623646417e-14
ko04725	Cholinergic synapse	60/1013	160/7206	7.16716940897e-14
ko04911	Insulin secretion	47/1013	117/7206	2.17225936952e-12
ko05031	Amphetamine addiction	40/1013	91/7206	3.18696530234e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1013	205/7206	5.30577495325e-12
ko04742	Taste transduction	30/1013	61/7206	5.35554107087e-11
ko04720	Long-term potentiation	40/1013	99/7206	7.88223342064e-11
ko04726	Serotonergic synapse	49/1013	137/7206	1.06672155334e-10
ko04970	Salivary secretion	36/1013	95/7206	5.57743276642e-09
ko04925	Aldosterone synthesis and secretion	37/1013	105/7206	3.34288102708e-08
ko04744	Phototransduction	19/1013	36/7206	4.40345772446e-08
ko03010	Ribosome	1/1013	129/7206	1.15892990292e-07
ko05030	Cocaine addiction	28/1013	73/7206	2.07351274346e-07
ko04966	Collecting duct acid secretion	15/1013	26/7206	2.53299351003e-07
ko04022	cGMP-PKG signaling pathway	58/1013	216/7206	4.60773523618e-07
ko04060	Cytokine-cytokine receptor interaction	6/1013	191/7206	7.17562561154e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1013	74/7206	1.0965474199e-06
ko05203	Viral carcinogenesis	14/1013	277/7206	1.44607712021e-06
ko04010	MAPK signaling pathway	76/1013	321/7206	2.25186074753e-06
ko04971	Gastric acid secretion	31/1013	98/7206	6.32199200096e-06
ko05168	Herpes simplex infection	7/1013	182/7206	7.03067768474e-06
ko03040	Spliceosome	4/1013	145/7206	8.77120193459e-06
ko05322	Systemic lupus erythematosus	5/1013	151/7206	1.50132469547e-05
ko04110	Cell cycle	5/1013	145/7206	3.10293517059e-05
ko04915	Estrogen signaling pathway	36/1013	131/7206	5.88916990415e-05
ko04740	Olfactory transduction	25/1013	80/7206	6.41859952443e-05
ko05110	Vibrio cholerae infection	21/1013	63/7206	8.04681253496e-05
ko04745	Phototransduction - fly	15/1013	38/7206	9.67693804406e-05
ko04730	Long-term depression	24/1013	78/7206	0.000115602271867
ko04070	Phosphatidylinositol signaling system	31/1013	112/7206	0.000155484125512
ko03013	RNA transport	8/1013	166/7206	0.000163597348689
ko04072	Phospholipase D signaling pathway	47/1013	197/7206	0.000165718768053
ko04514	Cell adhesion molecules (CAMs)	34/1013	130/7206	0.000284955495369
ko04626	Plant-pathogen interaction	9/1013	18/7206	0.000304434644278
ko04260	Cardiac muscle contraction	27/1013	98/7206	0.000371226321482
ko05164	Influenza A	9/1013	167/7206	0.000433405267649
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1013	79/7206	0.000455435449817
ko05169	Epstein-Barr virus infection	13/1013	206/7206	0.000513798684821
ko00562	Inositol phosphate metabolism	25/1013	89/7206	0.000543800599063
ko04922	Glucagon signaling pathway	32/1013	128/7206	0.000777672403467
ko05161	Hepatitis B	10/1013	173/7206	0.000795784040531
ko04371	Apelin signaling pathway	41/1013	177/7206	0.000926631609799
ko03008	Ribosome biogenesis in eukaryotes	2/1013	79/7206	0.000954713813166
ko04120	Ubiquitin mediated proteolysis	7/1013	138/7206	0.00113869443637
ko04972	Pancreatic secretion	28/1013	111/7206	0.00142430662666
ko04330	Notch signaling pathway	1/1013	62/7206	0.00148316102485
ko04750	Inflammatory mediator regulation of TRP channels	30/1013	122/7206	0.00151787963852
ko04621	NOD-like receptor signaling pathway	9/1013	157/7206	0.00153298757042
ko04924	Renin secretion	23/1013	86/7206	0.00159653337308
ko04014	Ras signaling pathway	58/1013	279/7206	0.00198612878273
ko05162	Measles	6/1013	120/7206	0.00211412274154
ko05140	Leishmaniasis	2/1013	75/7206	0.00212976678863
ko04630	Jak-STAT signaling pathway	7/1013	132/7206	0.0021552318065
ko05414	Dilated cardiomyopathy	28/1013	112/7206	0.00221332875012
ko04350	TGF-beta signaling pathway	5/1013	103/7206	0.00398959455416
ko04540	Gap junction	30/1013	128/7206	0.0043102757634
ko04964	Proximal tubule bicarbonate reclamation	10/1013	29/7206	0.00456574961903
ko00520	Amino sugar and nucleotide sugar metabolism	1/1013	55/7206	0.00517284545956
ko00480	Glutathione metabolism	1/1013	55/7206	0.00517284545956
ko05010	Alzheimer's disease	43/1013	202/7206	0.00525695941375
ko00240	Pyrimidine metabolism	6/1013	110/7206	0.00551794207777
ko05215	Prostate cancer	6/1013	111/7206	0.00552364678785
ko04270	Vascular smooth muscle contraction	34/1013	154/7206	0.00658901824345
ko00010	Glycolysis / Gluconeogenesis	19/1013	74/7206	0.00671531481262
ko00590	Arachidonic acid metabolism	1/1013	52/7206	0.00766092844084
ko05166	HTLV-I infection	26/1013	292/7206	0.00767727831263
ko04510	Focal adhesion	20/1013	240/7206	0.00795882364262
ko05206	MicroRNAs in cancer	13/1013	177/7206	0.00817184912929
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1013	14/7206	0.00832877776448
ko04976	Bile secretion	20/1013	80/7206	0.00867175348785
ko04550	Signaling pathways regulating pluripotency of stem cells	12/1013	165/7206	0.00887699013985
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1013	92/7206	0.00974579637684
ko04214	Apoptosis - fly	3/1013	72/7206	0.0101403134658
ko04064	NF-kappa B signaling pathway	5/1013	96/7206	0.0109435493822
ko05219	Bladder cancer	1/1013	48/7206	0.010986488904
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1013	100/7206	0.0134357953245
ko00190	Oxidative phosphorylation	28/1013	127/7206	0.0136769262211
ko00512	Mucin type O-glycan biosynthesis	9/1013	29/7206	0.014839055853
ko04360	Axon guidance	46/1013	233/7206	0.0161295418456
ko05144	Malaria	1/1013	45/7206	0.0162767618461
ko05321	Inflammatory bowel disease (IBD)	2/1013	56/7206	0.0191427532931
ko04657	IL-17 signaling pathway	5/1013	87/7206	0.019813340732
ko05130	Pathogenic Escherichia coli infection	4/1013	77/7206	0.0203439619651
ko05217	Basal cell carcinoma	3/1013	68/7206	0.0208096951187
ko04610	Complement and coagulation cascades	4/1013	79/7206	0.021010560587
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1013	59/7206	0.0215388633056
ko00983	Drug metabolism - other enzymes	1/1013	42/7206	0.0240747706885
ko04114	Oocyte meiosis	29/1013	139/7206	0.0258459429274
ko04115	p53 signaling pathway	4/1013	74/7206	0.0280888786334
ko04923	Regulation of lipolysis in adipocytes	18/1013	77/7206	0.0300013236275
ko05323	Rheumatoid arthritis	20/1013	89/7206	0.030241544849
ko05205	Proteoglycans in cancer	26/1013	271/7206	0.0321073227466
ko04962	Vasopressin-regulated water reabsorption	14/1013	58/7206	0.0353844156551
ko00630	Glyoxylate and dicarboxylate metabolism	1/1013	38/7206	0.0354433621671
ko03410	Base excision repair	1/1013	38/7206	0.0354433621671
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1013	40/7206	0.0364107390281
ko01230	Biosynthesis of amino acids	19/1013	85/7206	0.039272724142
ko04622	RIG-I-like receptor signaling pathway	3/1013	62/7206	0.0408580385551
ko05200	Pathways in cancer	54/1013	492/7206	0.0436047325621
ko04710	Circadian rhythm	11/1013	43/7206	0.0436620300152
ko05222	Small cell lung cancer	6/1013	89/7206	0.0454381487922
ko04930	Type II diabetes mellitus	13/1013	54/7206	0.0465075496856
ko00680	Methane metabolism	9/1013	34/7206	0.0465441255478
ko04912	GnRH signaling pathway	25/1013	122/7206	0.0477927487537
ko04210	Apoptosis	16/1013	180/7206	0.0496661898245