ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1150	423/7206	1.9649455342e-38
ko04724	Glutamatergic synapse	82/1150	152/7206	1.07455738167e-27
ko05033	Nicotine addiction	45/1150	56/7206	1.61100081926e-26
ko04721	Synaptic vesicle cycle	53/1150	80/7206	3.8539446205e-24
ko04727	GABAergic synapse	61/1150	110/7206	1.0873563939e-21
ko05032	Morphine addiction	60/1150	110/7206	7.35719305277e-21
ko04713	Circadian entrainment	68/1150	136/7206	1.10624288391e-20
ko04728	Dopaminergic synapse	80/1150	185/7206	3.72948869217e-19
ko04725	Cholinergic synapse	72/1150	160/7206	1.60705395735e-18
ko04742	Taste transduction	37/1150	61/7206	2.30603549423e-15
ko04723	Retrograde endocannabinoid signaling	71/1150	175/7206	2.39857918258e-15
ko04744	Phototransduction	27/1150	36/7206	5.05425087168e-15
ko04911	Insulin secretion	54/1150	117/7206	9.24939428786e-15
ko04024	cAMP signaling pathway	94/1150	279/7206	8.55085305614e-14
ko04740	Olfactory transduction	39/1150	80/7206	6.04264440138e-12
ko04726	Serotonergic synapse	55/1150	137/7206	6.06455482957e-12
ko04921	Oxytocin signaling pathway	69/1150	209/7206	5.81967947589e-10
ko05031	Amphetamine addiction	39/1150	91/7206	7.80841907018e-10
ko05203	Viral carcinogenesis	12/1150	277/7206	1.4245254602e-09
ko04360	Axon guidance	73/1150	233/7206	2.76404056424e-09
ko03040	Spliceosome	2/1150	145/7206	6.44548457353e-09
ko04020	Calcium signaling pathway	79/1150	265/7206	9.28787223676e-09
ko04720	Long-term potentiation	39/1150	99/7206	1.40959324413e-08
ko05164	Influenza A	5/1150	167/7206	8.91719849204e-08
ko04261	Adrenergic signaling in cardiomyocytes	63/1150	205/7206	9.66245204179e-08
ko03013	RNA transport	5/1150	166/7206	1.34746597234e-07
ko05030	Cocaine addiction	30/1150	73/7206	2.20881694495e-07
ko05168	Herpes simplex infection	7/1150	182/7206	3.12449521355e-07
ko04971	Gastric acid secretion	36/1150	98/7206	4.35317683527e-07
ko04970	Salivary secretion	35/1150	95/7206	5.93838434764e-07
ko04925	Aldosterone synthesis and secretion	37/1150	105/7206	1.13189636067e-06
ko04966	Collecting duct acid secretion	15/1150	26/7206	1.37081028801e-06
ko04120	Ubiquitin mediated proteolysis	4/1150	138/7206	1.49756098444e-06
ko05322	Systemic lupus erythematosus	6/1150	151/7206	4.9467254795e-06
ko04141	Protein processing in endoplasmic reticulum	9/1150	184/7206	5.12875785519e-06
ko04060	Cytokine-cytokine receptor interaction	10/1150	191/7206	7.73227322287e-06
ko04621	NOD-like receptor signaling pathway	7/1150	157/7206	1.21974875099e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1150	74/7206	1.537689248e-05
ko04610	Complement and coagulation cascades	1/1150	79/7206	3.31051956448e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1150	79/7206	3.31051956448e-05
ko04924	Renin secretion	29/1150	86/7206	4.05448530867e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1150	29/7206	4.66971261221e-05
ko04514	Cell adhesion molecules (CAMs)	39/1150	130/7206	4.96708817312e-05
ko04540	Gap junction	38/1150	128/7206	7.6694891702e-05
ko05162	Measles	5/1150	120/7206	7.76057497787e-05
ko04010	MAPK signaling pathway	77/1150	321/7206	0.00012522808455
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1150	79/7206	0.000156350332264
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1150	59/7206	0.000209686594033
ko05169	Epstein-Barr virus infection	15/1150	206/7206	0.000225920020068
ko04260	Cardiac muscle contraction	30/1150	98/7206	0.000240426490747
ko04976	Bile secretion	26/1150	80/7206	0.000288298647573
ko04022	cGMP-PKG signaling pathway	55/1150	216/7206	0.000298563019817
ko04146	Peroxisome	3/1150	89/7206	0.000356172475725
ko05140	Leishmaniasis	2/1150	75/7206	0.000386825718574
ko04730	Long-term depression	25/1150	78/7206	0.000449617165787
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1150	14/7206	0.000499681612528
ko04972	Pancreatic secretion	32/1150	111/7206	0.000566056006608
ko04064	NF-kappa B signaling pathway	4/1150	96/7206	0.000608093997012
ko05205	Proteoglycans in cancer	25/1150	271/7206	0.00127875456246
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1150	182/7206	0.00135805821908
ko00240	Pyrimidine metabolism	6/1150	110/7206	0.00140920402311
ko04745	Phototransduction - fly	14/1150	38/7206	0.00141891821763
ko05161	Hepatitis B	13/1150	173/7206	0.00147427369063
ko05110	Vibrio cholerae infection	20/1150	63/7206	0.00155162504422
ko00280	Valine, leucine and isoleucine degradation	1/1150	54/7206	0.0021379493202
ko03018	RNA degradation	4/1150	84/7206	0.0024587279069
ko00561	Glycerolipid metabolism	2/1150	63/7206	0.00274476565689
ko01200	Carbon metabolism	9/1150	128/7206	0.0033269267851
ko04110	Cell cycle	11/1150	145/7206	0.00392910920321
ko00330	Arginine and proline metabolism	2/1150	61/7206	0.00412223381183
ko05414	Dilated cardiomyopathy	29/1150	112/7206	0.00602547280982
ko03022	Basal transcription factors	1/1150	44/7206	0.00675467641989
ko04140	Autophagy - animal	14/1150	164/7206	0.00678081402321
ko05144	Malaria	1/1150	45/7206	0.00680253028731
ko00071	Fatty acid degradation	1/1150	45/7206	0.00680253028731
ko04612	Antigen processing and presentation	4/1150	77/7206	0.00705412839948
ko03420	Nucleotide excision repair	1/1150	46/7206	0.00708835209016
ko04916	Melanogenesis	35/1150	142/7206	0.00731076315275
ko04668	TNF signaling pathway	9/1150	120/7206	0.00802827396138
ko05321	Inflammatory bowel disease (IBD)	2/1150	56/7206	0.00888443944872
ko04640	Hematopoietic cell lineage	3/1150	64/7206	0.00939436054337
ko05131	Shigellosis	5/1150	82/7206	0.00979358325409
ko04115	p53 signaling pathway	4/1150	74/7206	0.00984305352186
ko04974	Protein digestion and absorption	25/1150	96/7206	0.0107947138603
ko04915	Estrogen signaling pathway	32/1150	131/7206	0.0110091346113
ko04750	Inflammatory mediator regulation of TRP channels	30/1150	122/7206	0.0122169539901
ko04014	Ras signaling pathway	60/1150	279/7206	0.0122395871013
ko00590	Arachidonic acid metabolism	2/1150	52/7206	0.0123391510819
ko04620	Toll-like receptor signaling pathway	7/1150	100/7206	0.0125002071447
ko04622	RIG-I-like receptor signaling pathway	3/1150	62/7206	0.0135156066286
ko00600	Sphingolipid metabolism	3/1150	63/7206	0.0139696876268
ko04214	Apoptosis - fly	4/1150	72/7206	0.0139991970844
ko05418	Fluid shear stress and atherosclerosis	16/1150	173/7206	0.0151007174089
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1150	40/7206	0.0152844099263
ko04626	Plant-pathogen interaction	7/1150	18/7206	0.0163228850999
ko04657	IL-17 signaling pathway	6/1150	87/7206	0.0177110079742
ko05133	Pertussis	6/1150	87/7206	0.0177110079742
ko00380	Tryptophan metabolism	2/1150	50/7206	0.0181631952066
ko00982	Drug metabolism - cytochrome P450	1/1150	37/7206	0.0225855903764
ko01524	Platinum drug resistance	5/1150	76/7206	0.0259295642744
ko00270	Cysteine and methionine metabolism	2/1150	47/7206	0.0260082963041
ko05145	Toxoplasmosis	11/1150	126/7206	0.026312220648
ko00564	Glycerophospholipid metabolism	8/1150	99/7206	0.0271572151022
ko04371	Apelin signaling pathway	39/1150	177/7206	0.029046145046
ko04217	Necroptosis	18/1150	178/7206	0.029385216627
ko04512	ECM-receptor interaction	20/1150	79/7206	0.029561132664
ko04210	Apoptosis	18/1150	180/7206	0.029732231417
ko04138	Autophagy - yeast	6/1150	81/7206	0.032225429285
ko04137	Mitophagy - animal	6/1150	82/7206	0.0324762316489
ko04218	Cellular senescence	18/1150	177/7206	0.0369284518404
ko00480	Glutathione metabolism	3/1150	55/7206	0.0392589506828
ko05166	HTLV-I infection	34/1150	292/7206	0.0411452907209
ko03320	PPAR signaling pathway	5/1150	69/7206	0.0469394961285
ko05215	Prostate cancer	10/1150	111/7206	0.0489399040441
ko04070	Phosphatidylinositol signaling system	26/1150	112/7206	0.0496838407429