ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 178/1038 423/7206 5.33676948876e-47 ko04724 Glutamatergic synapse 76/1038 152/7206 6.68488660025e-26 ko05033 Nicotine addiction 42/1038 56/7206 1.65996259543e-24 ko04713 Circadian entrainment 65/1038 136/7206 6.27371347262e-21 ko04020 Calcium signaling pathway 96/1038 265/7206 1.41521631341e-19 ko05032 Morphine addiction 54/1038 110/7206 3.05041048072e-18 ko04728 Dopaminergic synapse 72/1038 185/7206 7.45239222577e-17 ko04727 GABAergic synapse 51/1038 110/7206 5.67007720973e-16 ko04723 Retrograde endocannabinoid signaling 66/1038 175/7206 9.44203129091e-15 ko04024 cAMP signaling pathway 90/1038 279/7206 1.00067633506e-14 ko04921 Oxytocin signaling pathway 74/1038 209/7206 1.53099017893e-14 ko04725 Cholinergic synapse 60/1038 160/7206 2.17279355095e-13 ko04721 Synaptic vesicle cycle 38/1038 80/7206 1.23087382152e-12 ko04726 Serotonergic synapse 52/1038 137/7206 5.26607446212e-12 ko05031 Amphetamine addiction 40/1038 91/7206 7.05209005836e-12 ko04911 Insulin secretion 45/1038 117/7206 8.6965511803e-11 ko04970 Salivary secretion 39/1038 95/7206 1.62300400669e-10 ko04742 Taste transduction 29/1038 61/7206 5.7611361584e-10 ko04720 Long-term potentiation 39/1038 99/7206 6.98243627608e-10 ko04261 Adrenergic signaling in cardiomyocytes 63/1038 205/7206 1.67402746097e-09 ko04925 Aldosterone synthesis and secretion 39/1038 105/7206 5.14614073002e-09 ko04971 Gastric acid secretion 36/1038 98/7206 2.80908533801e-08 ko04022 cGMP-PKG signaling pathway 62/1038 216/7206 3.28384392164e-08 ko03040 Spliceosome 2/1038 145/7206 6.48983185545e-08 ko03010 Ribosome 1/1038 129/7206 7.31969557337e-08 ko05030 Cocaine addiction 27/1038 73/7206 1.30940516584e-06 ko04972 Pancreatic secretion 36/1038 111/7206 1.55052437967e-06 ko05322 Systemic lupus erythematosus 4/1038 151/7206 1.73896034327e-06 ko04110 Cell cycle 4/1038 145/7206 3.72849650611e-06 ko04070 Phosphatidylinositol signaling system 35/1038 112/7206 4.1661876997e-06 ko04730 Long-term depression 27/1038 78/7206 5.70059272681e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 26/1038 74/7206 6.20221590678e-06 ko04745 Phototransduction - fly 17/1038 38/7206 6.26297532239e-06 ko04744 Phototransduction 16/1038 36/7206 1.30334389082e-05 ko04060 Cytokine-cytokine receptor interaction 9/1038 191/7206 2.29244122915e-05 ko03013 RNA transport 7/1038 166/7206 2.7548168065e-05 ko05164 Influenza A 7/1038 167/7206 2.78919118427e-05 ko04750 Inflammatory mediator regulation of TRP channels 35/1038 122/7206 3.79970840336e-05 ko05203 Viral carcinogenesis 18/1038 277/7206 5.10114426982e-05 ko05168 Herpes simplex infection 9/1038 182/7206 6.18591631404e-05 ko04072 Phospholipase D signaling pathway 49/1038 197/7206 7.78738930169e-05 ko05162 Measles 4/1038 120/7206 0.000108559701985 ko05169 Epstein-Barr virus infection 12/1038 206/7206 0.000117157929718 ko03008 Ribosome biogenesis in eukaryotes 1/1038 79/7206 0.000132553682707 ko04924 Renin secretion 26/1038 86/7206 0.000142013176944 ko04270 Vascular smooth muscle contraction 40/1038 154/7206 0.000163509412198 ko04710 Circadian rhythm 16/1038 43/7206 0.000175294718726 ko04120 Ubiquitin mediated proteolysis 6/1038 138/7206 0.000199552983123 ko04260 Cardiac muscle contraction 28/1038 98/7206 0.000229665222991 ko04922 Glucagon signaling pathway 34/1038 128/7206 0.00029832511285 ko04540 Gap junction 34/1038 128/7206 0.00029832511285 ko04915 Estrogen signaling pathway 34/1038 131/7206 0.000393968050304 ko04010 MAPK signaling pathway 69/1038 321/7206 0.000439974211627 ko04621 NOD-like receptor signaling pathway 9/1038 157/7206 0.000791083828931 ko04350 TGF-beta signaling pathway 4/1038 103/7206 0.000952943471075 ko04930 Type II diabetes mellitus 17/1038 54/7206 0.00127670199166 ko04141 Protein processing in endoplasmic reticulum 12/1038 184/7206 0.00128660321927 ko05414 Dilated cardiomyopathy 29/1038 112/7206 0.00153283016325 ko04371 Apelin signaling pathway 41/1038 177/7206 0.00154469552455 ko05166 HTLV-I infection 24/1038 292/7206 0.00155471486974 ko04014 Ras signaling pathway 59/1038 279/7206 0.0016958879757 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/1038 79/7206 0.00178196122667 ko04626 Plant-pathogen interaction 8/1038 18/7206 0.00205762831606 ko04514 Cell adhesion molecules (CAMs) 32/1038 130/7206 0.00219057187196 ko05161 Hepatitis B 12/1038 173/7206 0.00295364619738 ko04550 Signaling pathways regulating pluripotency of stem cells 11/1038 165/7206 0.00326142380867 ko00562 Inositol phosphate metabolism 23/1038 89/7206 0.00368279024018 ko04630 Jak-STAT signaling pathway 8/1038 132/7206 0.00376311103038 ko05130 Pathogenic Escherichia coli infection 3/1038 77/7206 0.00496013248717 ko04612 Antigen processing and presentation 3/1038 77/7206 0.00496013248717 ko04964 Proximal tubule bicarbonate reclamation 10/1038 29/7206 0.00545541896239 ko04740 Olfactory transduction 21/1038 80/7206 0.00560837894711 ko05410 Hypertrophic cardiomyopathy (HCM) 25/1038 100/7206 0.00573739997477 ko05205 Proteoglycans in cancer 24/1038 271/7206 0.00619949923469 ko04923 Regulation of lipolysis in adipocytes 20/1038 77/7206 0.00792510413742 ko04966 Collecting duct acid secretion 9/1038 26/7206 0.0080333812671 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1038 14/7206 0.00939247896891 ko04330 Notch signaling pathway 2/1038 62/7206 0.00949274730854 ko04360 Axon guidance 48/1038 233/7206 0.0100712483939 ko04976 Bile secretion 20/1038 80/7206 0.0100919238659 ko04214 Apoptosis - fly 3/1038 72/7206 0.0102275469702 ko03420 Nucleotide excision repair 1/1038 46/7206 0.0107585158493 ko05219 Bladder cancer 1/1038 48/7206 0.0112667663238 ko04960 Aldosterone-regulated sodium reabsorption 12/1038 41/7206 0.012224252741 ko05200 Pathways in cancer 53/1038 492/7206 0.0165504871761 ko05110 Vibrio cholerae infection 16/1038 63/7206 0.0182789408209 ko00010 Glycolysis / Gluconeogenesis 18/1038 74/7206 0.019523870937 ko05140 Leishmaniasis 4/1038 75/7206 0.0201030997263 ko00680 Methane metabolism 10/1038 34/7206 0.023199886193 ko04622 RIG-I-like receptor signaling pathway 3/1038 62/7206 0.0281553670678 ko05215 Prostate cancer 8/1038 111/7206 0.0285040455197 ko04918 Thyroid hormone synthesis 20/1038 86/7206 0.0288199274498 ko04916 Melanogenesis 30/1038 142/7206 0.0288805997138 ko04015 Rap1 signaling pathway 53/1038 278/7206 0.0290650933801 ko05202 Transcriptional misregulation in cancer 17/1038 188/7206 0.0347426185002 ko05231 Choline metabolism in cancer 28/1038 134/7206 0.0348494556409 ko04341 Hedgehog signaling pathway - fly 1/1038 38/7206 0.0351558540175 ko03410 Base excision repair 1/1038 38/7206 0.0351558540175 ko04114 Oocyte meiosis 29/1038 139/7206 0.0371278519163 ko04113 Meiosis - yeast 4/1038 70/7206 0.0384980105139 ko05145 Toxoplasmosis 10/1038 126/7206 0.039531968891 ko04973 Carbohydrate digestion and absorption 11/1038 42/7206 0.0433946114479 ko04657 IL-17 signaling pathway 6/1038 87/7206 0.0450619245271 ko00230 Purine metabolism 38/1038 194/7206 0.0480346413064