ko pathway ratio_in_study ratio_in_pop p_value ko04720 Long-term potentiation 18/236 99/7206 2.3307674659e-09 ko04070 Phosphatidylinositol signaling system 18/236 112/7206 1.79742801266e-08 ko04745 Phototransduction - fly 11/236 38/7206 2.03089964611e-08 ko04921 Oxytocin signaling pathway 24/236 209/7206 6.66667282296e-08 ko05031 Amphetamine addiction 15/236 91/7206 2.04774180244e-07 ko04911 Insulin secretion 17/236 117/7206 2.08263836024e-07 ko04713 Circadian entrainment 18/236 136/7206 3.83076017707e-07 ko04626 Plant-pathogen interaction 7/236 18/7206 8.64805280559e-07 ko04925 Aldosterone synthesis and secretion 15/236 105/7206 1.38067587634e-06 ko04725 Cholinergic synapse 18/236 160/7206 4.24962722349e-06 ko04020 Calcium signaling pathway 24/236 265/7206 5.22683518168e-06 ko04721 Synaptic vesicle cycle 12/236 80/7206 9.63175708589e-06 ko00680 Methane metabolism 8/236 34/7206 1.02075101882e-05 ko04970 Salivary secretion 13/236 95/7206 1.14989784938e-05 ko04966 Collecting duct acid secretion 7/236 26/7206 1.4278595544e-05 ko04924 Renin secretion 12/236 86/7206 2.05403770232e-05 ko04728 Dopaminergic synapse 18/236 185/7206 3.20442059279e-05 ko05110 Vibrio cholerae infection 10/236 63/7206 3.25978573131e-05 ko04114 Oocyte meiosis 15/236 139/7206 4.4877047669e-05 ko04922 Glucagon signaling pathway 14/236 128/7206 6.96220567466e-05 ko04971 Gastric acid secretion 12/236 98/7206 7.70773916828e-05 ko04022 cGMP-PKG signaling pathway 19/236 216/7206 7.79030733774e-05 ko04750 Inflammatory mediator regulation of TRP channels 13/236 122/7206 0.000165168915763 ko04066 HIF-1 signaling pathway 13/236 123/7206 0.000179407761363 ko05214 Glioma 10/236 79/7206 0.000232194345334 ko04137 Mitophagy - animal 10/236 82/7206 0.00031640747048 ko00051 Fructose and mannose metabolism 7/236 42/7206 0.000374442057647 ko04024 cAMP signaling pathway 21/236 279/7206 0.000377327495668 ko04724 Glutamatergic synapse 14/236 152/7206 0.000433166947621 ko04726 Serotonergic synapse 13/236 137/7206 0.000520352642721 ko04912 GnRH signaling pathway 12/236 122/7206 0.000615472407802 ko00562 Inositol phosphate metabolism 10/236 89/7206 0.0006156364877 ko00010 Glycolysis / Gluconeogenesis 9/236 74/7206 0.000642601803594 ko04730 Long-term depression 9/236 78/7206 0.000946566332086 ko04261 Adrenergic signaling in cardiomyocytes 16/236 205/7206 0.00107829048318 ko04740 Olfactory transduction 9/236 80/7206 0.00113735599378 ko04080 Neuroactive ligand-receptor interaction 26/236 423/7206 0.0016976304405 ko01230 Biosynthesis of amino acids 9/236 85/7206 0.00175281781304 ko04371 Apelin signaling pathway 14/236 177/7206 0.00193368344227 ko04360 Axon guidance 17/236 233/7206 0.0019693523355 ko04722 Neurotrophin signaling pathway 13/236 160/7206 0.00219453677125 ko00190 Oxidative phosphorylation 11/236 127/7206 0.00288454629965 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/236 92/7206 0.00303472847487 ko05010 Alzheimer's disease 15/236 202/7206 0.00359644659556 ko04270 Vascular smooth muscle contraction 12/236 154/7206 0.0045187778502 ko05230 Central carbon metabolism in cancer 8/236 81/7206 0.0048167503823 ko05152 Tuberculosis 14/236 187/7206 0.00503450130069 ko04744 Phototransduction 5/236 36/7206 0.0059383054253 ko04916 Melanogenesis 11/236 142/7206 0.00673602372345 ko04218 Cellular senescence 13/236 177/7206 0.00780669080671 ko05323 Rheumatoid arthritis 8/236 89/7206 0.00846395572063 ko04727 GABAergic synapse 9/236 110/7206 0.00977464590654 ko05014 Amyotrophic lateral sclerosis (ALS) 7/236 74/7206 0.010311283673 ko04723 Retrograde endocannabinoid signaling 12/236 175/7206 0.0148631001701 ko04138 Autophagy - yeast 7/236 81/7206 0.0164502743789 ko04136 Autophagy - other 4/236 31/7206 0.0176210253332 ko00030 Pentose phosphate pathway 4/236 32/7206 0.0196344519438 ko04060 Cytokine-cytokine receptor interaction 1/236 191/7206 0.0218915671058 ko04012 ErbB signaling pathway 8/236 109/7206 0.0261767385008 ko04016 MAPK signaling pathway - plant 3/236 20/7206 0.0261949818972 ko05032 Morphine addiction 8/236 110/7206 0.0274631771354 ko04972 Pancreatic secretion 8/236 111/7206 0.0287929002391 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/236 1/7206 0.0327504857065 ko05134 Legionellosis 6/236 74/7206 0.0336892279083 ko00230 Purine metabolism 12/236 194/7206 0.0363603964108 ko04540 Gap junction 9/236 128/7206 0.037821863887 ko04370 VEGF signaling pathway 6/236 77/7206 0.0398094379886 ko04915 Estrogen signaling pathway 9/236 131/7206 0.0399279056719 ko00564 Glycerophospholipid metabolism 7/236 99/7206 0.0431908884416 ko04145 Phagosome 10/236 162/7206 0.0439564261068