ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/1055	423/7206	7.33458086107e-42
ko05033	Nicotine addiction	47/1055	56/7206	4.94627667674e-31
ko04724	Glutamatergic synapse	82/1055	152/7206	2.04159722888e-30
ko05032	Morphine addiction	65/1055	110/7206	2.20716299892e-27
ko04727	GABAergic synapse	61/1055	110/7206	1.03021057515e-23
ko04713	Circadian entrainment	68/1055	136/7206	7.40675129565e-23
ko04721	Synaptic vesicle cycle	47/1055	80/7206	5.8867723066e-20
ko04723	Retrograde endocannabinoid signaling	74/1055	175/7206	2.50541913567e-19
ko04728	Dopaminergic synapse	76/1055	185/7206	6.24679145582e-19
ko04725	Cholinergic synapse	69/1055	160/7206	1.18412137893e-18
ko04024	cAMP signaling pathway	94/1055	279/7206	3.02923108056e-16
ko04742	Taste transduction	33/1055	61/7206	5.60935720119e-13
ko04744	Phototransduction	24/1055	36/7206	1.58822993314e-12
ko04261	Adrenergic signaling in cardiomyocytes	69/1055	205/7206	3.40081492879e-12
ko04911	Insulin secretion	47/1055	117/7206	9.6286619521e-12
ko04726	Serotonergic synapse	52/1055	137/7206	9.95407797014e-12
ko04020	Calcium signaling pathway	80/1055	265/7206	3.78646340109e-11
ko04921	Oxytocin signaling pathway	67/1055	209/7206	1.02463782708e-10
ko03040	Spliceosome	1/1055	145/7206	3.52218078372e-09
ko05031	Amphetamine addiction	36/1055	91/7206	4.34584349522e-09
ko04720	Long-term potentiation	38/1055	99/7206	4.4055738912e-09
ko04360	Axon guidance	67/1055	233/7206	1.51654424635e-08
ko05203	Viral carcinogenesis	13/1055	277/7206	1.29470240066e-07
ko05168	Herpes simplex infection	6/1055	182/7206	6.35106527425e-07
ko04060	Cytokine-cytokine receptor interaction	7/1055	191/7206	1.14734946979e-06
ko05322	Systemic lupus erythematosus	4/1055	151/7206	1.15348605509e-06
ko05030	Cocaine addiction	27/1055	73/7206	1.80988994965e-06
ko04970	Salivary secretion	32/1055	95/7206	2.5184327471e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1055	79/7206	3.11968244515e-06
ko04925	Aldosterone synthesis and secretion	34/1055	105/7206	4.04020446096e-06
ko04010	MAPK signaling pathway	77/1055	321/7206	5.20430233785e-06
ko03013	RNA transport	6/1055	166/7206	5.91347698365e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1055	74/7206	8.39083448705e-06
ko05164	Influenza A	7/1055	167/7206	1.91823615623e-05
ko04022	cGMP-PKG signaling pathway	55/1055	216/7206	2.15021836614e-05
ko04514	Cell adhesion molecules (CAMs)	37/1055	130/7206	4.30933448255e-05
ko05205	Proteoglycans in cancer	18/1055	271/7206	4.89984360175e-05
ko05414	Dilated cardiomyopathy	33/1055	112/7206	6.28375467947e-05
ko04260	Cardiac muscle contraction	30/1055	98/7206	6.52069040514e-05
ko04971	Gastric acid secretion	30/1055	98/7206	6.52069040514e-05
ko04141	Protein processing in endoplasmic reticulum	10/1055	184/7206	0.000118910058506
ko04966	Collecting duct acid secretion	12/1055	26/7206	0.000120234647956
ko04070	Phosphatidylinositol signaling system	32/1055	112/7206	0.000121019883119
ko04072	Phospholipase D signaling pathway	49/1055	197/7206	0.000131258224152
ko04621	NOD-like receptor signaling pathway	8/1055	157/7206	0.000218592408972
ko04972	Pancreatic secretion	31/1055	111/7206	0.000334818229553
ko04120	Ubiquitin mediated proteolysis	7/1055	138/7206	0.000569864726865
ko04730	Long-term depression	23/1055	78/7206	0.000608897440501
ko05169	Epstein-Barr virus infection	14/1055	206/7206	0.000621402897854
ko03008	Ribosome biogenesis in eukaryotes	2/1055	79/7206	0.000626576547726
ko04014	Ras signaling pathway	61/1055	279/7206	0.00096543063523
ko04640	Hematopoietic cell lineage	1/1055	64/7206	0.00100553535778
ko04740	Olfactory transduction	23/1055	80/7206	0.00113698555636
ko05140	Leishmaniasis	2/1055	75/7206	0.00141635389352
ko04915	Estrogen signaling pathway	33/1055	131/7206	0.00158449015927
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1055	14/7206	0.0018875216091
ko04064	NF-kappa B signaling pathway	4/1055	96/7206	0.0019215665774
ko04745	Phototransduction - fly	13/1055	38/7206	0.00202264617493
ko05161	Hepatitis B	12/1055	173/7206	0.00220721945454
ko04976	Bile secretion	22/1055	80/7206	0.00230107645991
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1055	59/7206	0.00233766885045
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1055	100/7206	0.00250914497489
ko04924	Renin secretion	23/1055	86/7206	0.00309690970431
ko00480	Glutathione metabolism	1/1055	55/7206	0.00327781475118
ko04146	Peroxisome	4/1055	89/7206	0.00373888090301
ko05162	Measles	7/1055	120/7206	0.00385762249515
ko00240	Pyrimidine metabolism	6/1055	110/7206	0.00393376321019
ko04371	Apelin signaling pathway	40/1055	177/7206	0.0047962667431
ko00590	Arachidonic acid metabolism	1/1055	52/7206	0.00486446454424
ko04612	Antigen processing and presentation	3/1055	77/7206	0.00506409050539
ko04964	Proximal tubule bicarbonate reclamation	10/1055	29/7206	0.00613624145239
ko04510	Focal adhesion	21/1055	240/7206	0.00693741504482
ko04214	Apoptosis - fly	3/1055	72/7206	0.00696647687131
ko00260	Glycine, serine and threonine metabolism	1/1055	48/7206	0.00715894940503
ko04540	Gap junction	30/1055	128/7206	0.0075559009675
ko03320	PPAR signaling pathway	3/1055	69/7206	0.0099114866332
ko00071	Fatty acid degradation	1/1055	45/7206	0.0106764184392
ko05110	Vibrio cholerae infection	17/1055	63/7206	0.0106967819159
ko03420	Nucleotide excision repair	1/1055	46/7206	0.0107112703259
ko04140	Autophagy - animal	13/1055	164/7206	0.0133862977051
ko05145	Toxoplasmosis	9/1055	126/7206	0.015001581572
ko03022	Basal transcription factors	1/1055	44/7206	0.0162804866168
ko04217	Necroptosis	15/1055	178/7206	0.0175889254448
ko00280	Valine, leucine and isoleucine degradation	2/1055	54/7206	0.01882661127
ko04658	Th1 and Th2 cell differentiation	6/1055	96/7206	0.0188645124882
ko04115	p53 signaling pathway	4/1055	74/7206	0.0199544168666
ko04923	Regulation of lipolysis in adipocytes	19/1055	77/7206	0.0215021745181
ko00562	Inositol phosphate metabolism	21/1055	89/7206	0.0226267029123
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1055	40/7206	0.0235279220519
ko00140	Steroid hormone biosynthesis	1/1055	41/7206	0.0239963105488
ko04210	Apoptosis	16/1055	180/7206	0.0247851715618
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1055	182/7206	0.0250468884746
ko00983	Drug metabolism - other enzymes	1/1055	42/7206	0.0250633255491
ko00380	Tryptophan metabolism	2/1055	50/7206	0.0268687342166
ko04750	Inflammatory mediator regulation of TRP channels	27/1055	122/7206	0.0269611084377
ko00330	Arginine and proline metabolism	3/1055	61/7206	0.0279502838942
ko04622	RIG-I-like receptor signaling pathway	3/1055	62/7206	0.0283885611661
ko00310	Lysine degradation	4/1055	73/7206	0.0285215975125
ko04930	Type II diabetes mellitus	14/1055	54/7206	0.0306511644654
ko04110	Cell cycle	12/1055	145/7206	0.0316739287508
ko00982	Drug metabolism - cytochrome P450	1/1055	37/7206	0.0348050783584
ko03410	Base excision repair	1/1055	38/7206	0.0353392990317
ko04626	Plant-pathogen interaction	6/1055	18/7206	0.0375247599416
ko05219	Bladder cancer	2/1055	48/7206	0.0386946745222
ko04062	Chemokine signaling pathway	40/1055	201/7206	0.0421864638366
ko04657	IL-17 signaling pathway	6/1055	87/7206	0.0455058867031
ko05133	Pertussis	6/1055	87/7206	0.0455058867031
ko04630	Jak-STAT signaling pathway	11/1055	132/7206	0.0455127401104
ko00513	Various types of N-glycan biosynthesis	11/1055	42/7206	0.0458519207965
ko05231	Choline metabolism in cancer	28/1055	134/7206	0.0474773833742
ko01524	Platinum drug resistance	5/1055	76/7206	0.0488308852034
ko04391	Hippo signaling pathway - fly	20/1055	90/7206	0.0498880543473