ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1082	423/7206	2.97986804591e-51
ko05033	Nicotine addiction	49/1082	56/7206	1.39158297049e-33
ko04724	Glutamatergic synapse	84/1082	152/7206	2.43037975811e-31
ko05032	Morphine addiction	64/1082	110/7206	8.38097182887e-26
ko04713	Circadian entrainment	72/1082	136/7206	1.96498214546e-25
ko04727	GABAergic synapse	63/1082	110/7206	6.84251394588e-25
ko04721	Synaptic vesicle cycle	52/1082	80/7206	2.13304315329e-24
ko04728	Dopaminergic synapse	79/1082	185/7206	3.45186615032e-20
ko04725	Cholinergic synapse	70/1082	160/7206	1.04767583602e-18
ko04723	Retrograde endocannabinoid signaling	74/1082	175/7206	1.12046451217e-18
ko04742	Taste transduction	38/1082	61/7206	3.2401105712e-17
ko04024	cAMP signaling pathway	97/1082	279/7206	5.54047941928e-17
ko04911	Insulin secretion	55/1082	117/7206	1.21733212757e-16
ko04726	Serotonergic synapse	56/1082	137/7206	1.17855579754e-13
ko04020	Calcium signaling pathway	85/1082	265/7206	1.00884897748e-12
ko04720	Long-term potentiation	44/1082	99/7206	1.68556694142e-12
ko05031	Amphetamine addiction	41/1082	91/7206	5.67111182789e-12
ko04921	Oxytocin signaling pathway	69/1082	209/7206	3.93859074651e-11
ko04744	Phototransduction	22/1082	36/7206	2.88340210459e-10
ko04261	Adrenergic signaling in cardiomyocytes	66/1082	205/7206	4.46378283114e-10
ko04740	Olfactory transduction	35/1082	80/7206	5.55616663026e-10
ko03040	Spliceosome	1/1082	145/7206	2.19310121885e-09
ko04970	Salivary secretion	38/1082	95/7206	2.3097285672e-09
ko05030	Cocaine addiction	32/1082	73/7206	2.88729964002e-09
ko05203	Viral carcinogenesis	13/1082	277/7206	4.30181558765e-08
ko05168	Herpes simplex infection	5/1082	182/7206	7.23002369332e-08
ko04925	Aldosterone synthesis and secretion	38/1082	105/7206	9.14748276981e-08
ko04971	Gastric acid secretion	35/1082	98/7206	3.87862602813e-07
ko04060	Cytokine-cytokine receptor interaction	7/1082	191/7206	5.14511234317e-07
ko04360	Axon guidance	64/1082	233/7206	5.62806379709e-07
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1082	59/7206	1.46752483006e-06
ko03013	RNA transport	6/1082	166/7206	2.64417914957e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1082	74/7206	4.03226047957e-06
ko04010	MAPK signaling pathway	79/1082	321/7206	4.22872332958e-06
ko04022	cGMP-PKG signaling pathway	57/1082	216/7206	1.05233963439e-05
ko04924	Renin secretion	29/1082	86/7206	1.15816532412e-05
ko04730	Long-term depression	27/1082	78/7206	1.54104104914e-05
ko05322	Systemic lupus erythematosus	6/1082	151/7206	2.42498061558e-05
ko04540	Gap junction	38/1082	128/7206	2.51591756622e-05
ko04966	Collecting duct acid secretion	13/1082	26/7206	2.82443909701e-05
ko04120	Ubiquitin mediated proteolysis	5/1082	138/7206	3.00207688468e-05
ko05164	Influenza A	8/1082	167/7206	3.99037214978e-05
ko04745	Phototransduction - fly	16/1082	38/7206	5.04357818169e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1082	79/7206	5.1689623868e-05
ko04141	Protein processing in endoplasmic reticulum	10/1082	184/7206	5.98520265599e-05
ko04514	Cell adhesion molecules (CAMs)	37/1082	130/7206	9.05246606421e-05
ko05169	Epstein-Barr virus infection	13/1082	206/7206	0.000147729159783
ko04621	NOD-like receptor signaling pathway	8/1082	157/7206	0.000156763646031
ko04972	Pancreatic secretion	32/1082	111/7206	0.000226058122145
ko05162	Measles	5/1082	120/7206	0.000247270920458
ko04260	Cardiac muscle contraction	29/1082	98/7206	0.000272585058172
ko04072	Phospholipase D signaling pathway	48/1082	197/7206	0.000518225541719
ko04612	Antigen processing and presentation	2/1082	77/7206	0.000610847885007
ko04610	Complement and coagulation cascades	2/1082	79/7206	0.00065312377632
ko03008	Ribosome biogenesis in eukaryotes	2/1082	79/7206	0.00065312377632
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1082	182/7206	0.000689687492271
ko00240	Pyrimidine metabolism	5/1082	110/7206	0.000700110806884
ko04976	Bile secretion	24/1082	80/7206	0.000703421463757
ko05140	Leishmaniasis	2/1082	75/7206	0.000910116649967
ko00330	Arginine and proline metabolism	1/1082	61/7206	0.000934639958545
ko04014	Ras signaling pathway	62/1082	279/7206	0.00109430833076
ko04750	Inflammatory mediator regulation of TRP channels	32/1082	122/7206	0.00120430356488
ko04064	NF-kappa B signaling pathway	4/1082	96/7206	0.00130553155178
ko04214	Apoptosis - fly	2/1082	72/7206	0.00133044979628
ko04110	Cell cycle	9/1082	145/7206	0.00141205907362
ko05205	Proteoglycans in cancer	23/1082	271/7206	0.00170009157087
ko04915	Estrogen signaling pathway	33/1082	131/7206	0.00190280135283
ko05110	Vibrio cholerae infection	19/1082	63/7206	0.00205394511465
ko00480	Glutathione metabolism	1/1082	55/7206	0.00210416470223
ko04964	Proximal tubule bicarbonate reclamation	11/1082	29/7206	0.00212296022467
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1082	14/7206	0.00219619160081
ko04146	Peroxisome	4/1082	89/7206	0.00258651442238
ko05414	Dilated cardiomyopathy	29/1082	112/7206	0.00295521108795
ko04070	Phosphatidylinositol signaling system	29/1082	112/7206	0.00295521108795
ko04640	Hematopoietic cell lineage	2/1082	64/7206	0.00420297993967
ko03018	RNA degradation	4/1082	84/7206	0.00517616975017
ko00260	Glycine, serine and threonine metabolism	1/1082	48/7206	0.00713869330915
ko05166	HTLV-I infection	28/1082	292/7206	0.007245246786
ko04371	Apelin signaling pathway	40/1082	177/7206	0.00732948776589
ko04140	Autophagy - animal	13/1082	164/7206	0.00777376897996
ko05418	Fluid shear stress and atherosclerosis	14/1082	173/7206	0.0092663799686
ko05161	Hepatitis B	14/1082	173/7206	0.0092663799686
ko03022	Basal transcription factors	1/1082	44/7206	0.0105058829821
ko04217	Necroptosis	15/1082	178/7206	0.0105449716538
ko05144	Malaria	1/1082	45/7206	0.0105768561545
ko00071	Fatty acid degradation	1/1082	45/7206	0.0105768561545
ko00620	Pyruvate metabolism	1/1082	46/7206	0.010956424535
ko03420	Nucleotide excision repair	1/1082	46/7206	0.010956424535
ko05145	Toxoplasmosis	9/1082	126/7206	0.0112217150085
ko04930	Type II diabetes mellitus	15/1082	54/7206	0.0127135477409
ko05321	Inflammatory bowel disease (IBD)	2/1082	56/7206	0.013033417331
ko01524	Platinum drug resistance	4/1082	76/7206	0.0143369816168
ko00983	Drug metabolism - other enzymes	1/1082	42/7206	0.0156775516265
ko00140	Steroid hormone biosynthesis	1/1082	41/7206	0.0156792744805
ko04350	TGF-beta signaling pathway	7/1082	103/7206	0.0172984023959
ko01200	Carbon metabolism	10/1082	128/7206	0.0176322257634
ko00280	Valine, leucine and isoleucine degradation	2/1082	54/7206	0.0194153272337
ko04668	TNF signaling pathway	9/1082	120/7206	0.0195269029152
ko04622	RIG-I-like receptor signaling pathway	3/1082	62/7206	0.0195786187092
ko00600	Sphingolipid metabolism	3/1082	63/7206	0.0197970056683
ko04015	Rap1 signaling pathway	56/1082	278/7206	0.0203694370001
ko04912	GnRH signaling pathway	28/1082	122/7206	0.020416308433
ko04620	Toll-like receptor signaling pathway	7/1082	100/7206	0.0231062022006
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1082	40/7206	0.0237137646179
ko04630	Jak-STAT signaling pathway	11/1082	132/7206	0.0268370816023
ko03320	PPAR signaling pathway	4/1082	69/7206	0.0272580974611
ko04658	Th1 and Th2 cell differentiation	7/1082	96/7206	0.0305292675248
ko04916	Melanogenesis	31/1082	142/7206	0.031674958985
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1082	100/7206	0.0332029649007
ko04657	IL-17 signaling pathway	6/1082	87/7206	0.0333291761036
ko05133	Pertussis	6/1082	87/7206	0.0333291761036
ko00982	Drug metabolism - cytochrome P450	1/1082	37/7206	0.0348997670471
ko04062	Chemokine signaling pathway	41/1082	201/7206	0.0351613264521
ko03410	Base excision repair	1/1082	38/7206	0.0362569598065
ko05231	Choline metabolism in cancer	29/1082	134/7206	0.0372384400434
ko00270	Cysteine and methionine metabolism	2/1082	47/7206	0.0384003419773
ko04978	Mineral absorption	11/1082	40/7206	0.0416120396036
ko04626	Plant-pathogen interaction	6/1082	18/7206	0.041875256273
ko05034	Alcoholism	47/1082	238/7206	0.0421625480245
ko05215	Prostate cancer	9/1082	111/7206	0.0434384355111
ko00310	Lysine degradation	5/1082	73/7206	0.0480957055657
ko04115	p53 signaling pathway	5/1082	74/7206	0.0483122916069