ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1190	423/7206	4.50257372464e-50
ko04724	Glutamatergic synapse	87/1190	152/7206	8.82023183379e-31
ko05033	Nicotine addiction	47/1190	56/7206	1.31653462466e-28
ko05032	Morphine addiction	68/1190	110/7206	4.85605711397e-27
ko04713	Circadian entrainment	77/1190	136/7206	6.55298859854e-27
ko04727	GABAergic synapse	65/1190	110/7206	2.61499345445e-24
ko04728	Dopaminergic synapse	87/1190	185/7206	9.52075543886e-23
ko04721	Synaptic vesicle cycle	52/1190	80/7206	2.06952856389e-22
ko04725	Cholinergic synapse	77/1190	160/7206	5.17690174735e-21
ko04723	Retrograde endocannabinoid signaling	78/1190	175/7206	9.60250279772e-19
ko04024	cAMP signaling pathway	105/1190	279/7206	5.01882060149e-18
ko04020	Calcium signaling pathway	100/1190	265/7206	1.98565949094e-17
ko04911	Insulin secretion	58/1190	117/7206	7.26137545088e-17
ko04742	Taste transduction	39/1190	61/7206	9.6710098535e-17
ko04921	Oxytocin signaling pathway	81/1190	209/7206	5.32245718455e-15
ko04726	Serotonergic synapse	60/1190	137/7206	2.93301019571e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1190	205/7206	5.22110468737e-13
ko04970	Salivary secretion	44/1190	95/7206	8.32511485249e-12
ko05031	Amphetamine addiction	41/1190	91/7206	1.2706700805e-10
ko04720	Long-term potentiation	43/1190	99/7206	1.9225402956e-10
ko03040	Spliceosome	1/1190	145/7206	1.95462752702e-10
ko04744	Phototransduction	23/1190	36/7206	2.2002662335e-10
ko04740	Olfactory transduction	35/1190	80/7206	7.55940688426e-09
ko05203	Viral carcinogenesis	15/1190	277/7206	1.99541253043e-08
ko04925	Aldosterone synthesis and secretion	41/1190	105/7206	2.75310526974e-08
ko04060	Cytokine-cytokine receptor interaction	7/1190	191/7206	3.04086048384e-08
ko04022	cGMP-PKG signaling pathway	68/1190	216/7206	3.71105554658e-08
ko04971	Gastric acid secretion	39/1190	98/7206	4.50021869771e-08
ko04360	Axon guidance	71/1190	233/7206	7.48509492972e-08
ko04924	Renin secretion	33/1190	86/7206	1.01327002987e-06
ko03013	RNA transport	7/1190	166/7206	1.27062371935e-06
ko05030	Cocaine addiction	29/1190	73/7206	1.7030517394e-06
ko04966	Collecting duct acid secretion	15/1190	26/7206	2.14767417358e-06
ko05322	Systemic lupus erythematosus	6/1190	151/7206	2.21853336826e-06
ko04120	Ubiquitin mediated proteolysis	5/1190	138/7206	3.94072489501e-06
ko04972	Pancreatic secretion	38/1190	111/7206	3.95729177184e-06
ko04514	Cell adhesion molecules (CAMs)	42/1190	130/7206	7.05563594935e-06
ko04070	Phosphatidylinositol signaling system	38/1190	112/7206	7.46011587713e-06
ko05168	Herpes simplex infection	10/1190	182/7206	1.02043525066e-05
ko04540	Gap junction	41/1190	128/7206	1.12118867031e-05
ko04010	MAPK signaling pathway	83/1190	321/7206	1.42284606767e-05
ko05164	Influenza A	9/1190	167/7206	1.88033960736e-05
ko04976	Bile secretion	29/1190	80/7206	2.2702806464e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1190	74/7206	2.60504925439e-05
ko04745	Phototransduction - fly	17/1190	38/7206	4.00863834354e-05
ko05110	Vibrio cholerae infection	24/1190	63/7206	4.12689710395e-05
ko04141	Protein processing in endoplasmic reticulum	12/1190	184/7206	7.30720905254e-05
ko04730	Long-term depression	27/1190	78/7206	8.33960948935e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1190	79/7206	0.000101920851223
ko03008	Ribosome biogenesis in eukaryotes	2/1190	79/7206	0.000174784885981
ko04260	Cardiac muscle contraction	31/1190	98/7206	0.000175841562329
ko04072	Phospholipase D signaling pathway	53/1190	197/7206	0.000190164144332
ko04621	NOD-like receptor signaling pathway	10/1190	157/7206	0.000192045430529
ko05140	Leishmaniasis	2/1190	75/7206	0.0002499818785
ko05414	Dilated cardiomyopathy	34/1190	112/7206	0.000258514764442
ko04110	Cell cycle	9/1190	145/7206	0.000265563620479
ko05169	Epstein-Barr virus infection	16/1190	206/7206	0.000271491724656
ko04371	Apelin signaling pathway	48/1190	177/7206	0.000297044003441
ko05205	Proteoglycans in cancer	24/1190	271/7206	0.00030846882703
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1190	59/7206	0.000310310026043
ko04964	Proximal tubule bicarbonate reclamation	13/1190	29/7206	0.0003183883313
ko04750	Inflammatory mediator regulation of TRP channels	35/1190	122/7206	0.000760869216721
ko04146	Peroxisome	4/1190	89/7206	0.000817271343896
ko04014	Ras signaling pathway	67/1190	279/7206	0.000964967816275
ko04612	Antigen processing and presentation	3/1190	77/7206	0.00102086208285
ko04626	Plant-pathogen interaction	9/1190	18/7206	0.00103892506814
ko04915	Estrogen signaling pathway	36/1190	131/7206	0.0012571452438
ko04064	NF-kappa B signaling pathway	5/1190	96/7206	0.0012724451616
ko05162	Measles	8/1190	120/7206	0.00181993111015
ko04640	Hematopoietic cell lineage	2/1190	64/7206	0.00185225853504
ko00240	Pyrimidine metabolism	7/1190	110/7206	0.00260299694985
ko00260	Glycine, serine and threonine metabolism	1/1190	48/7206	0.00290942694338
ko04923	Regulation of lipolysis in adipocytes	23/1190	77/7206	0.0030288196085
ko05161	Hepatitis B	15/1190	173/7206	0.00354588703878
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1190	14/7206	0.00385717982446
ko05144	Malaria	1/1190	45/7206	0.00438619467289
ko00071	Fatty acid degradation	1/1190	45/7206	0.00438619467289
ko03420	Nucleotide excision repair	1/1190	46/7206	0.00441185964373
ko00480	Glutathione metabolism	2/1190	55/7206	0.00563997146721
ko00562	Inositol phosphate metabolism	25/1190	89/7206	0.00575672133978
ko05321	Inflammatory bowel disease (IBD)	2/1190	56/7206	0.00575893789131
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1190	182/7206	0.00624328177794
ko03022	Basal transcription factors	1/1190	44/7206	0.00674231590089
ko00310	Lysine degradation	4/1190	73/7206	0.0067847543993
ko03018	RNA degradation	5/1190	84/7206	0.00704955896479
ko05166	HTLV-I infection	32/1190	292/7206	0.00781159289044
ko04270	Vascular smooth muscle contraction	38/1190	154/7206	0.00822448380075
ko00590	Arachidonic acid metabolism	2/1190	52/7206	0.00824787721574
ko04630	Jak-STAT signaling pathway	11/1190	132/7206	0.00884854738429
ko04622	RIG-I-like receptor signaling pathway	3/1190	62/7206	0.00918746208612
ko00330	Arginine and proline metabolism	3/1190	61/7206	0.00918874923468
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1190	100/7206	0.00920787389301
ko04214	Apoptosis - fly	4/1190	72/7206	0.00972081159738
ko04658	Th1 and Th2 cell differentiation	7/1190	96/7206	0.012103342431
ko04657	IL-17 signaling pathway	6/1190	87/7206	0.0127873846344
ko05133	Pertussis	6/1190	87/7206	0.0127873846344
ko04210	Apoptosis	18/1190	180/7206	0.0146204865782
ko05219	Bladder cancer	2/1190	48/7206	0.0176362212763
ko04115	p53 signaling pathway	5/1190	74/7206	0.0182229461339
ko04217	Necroptosis	18/1190	178/7206	0.0184271759611
ko04912	GnRH signaling pathway	30/1190	122/7206	0.0192420499961
ko00500	Starch and sucrose metabolism	1/1190	35/7206	0.0220901271448
ko04710	Circadian rhythm	13/1190	43/7206	0.0220975712675
ko04922	Glucagon signaling pathway	31/1190	128/7206	0.0221705782911
ko05131	Shigellosis	6/1190	82/7206	0.0237058243611
ko00280	Valine, leucine and isoleucine degradation	3/1190	54/7206	0.0263122051008
ko04918	Thyroid hormone synthesis	22/1190	86/7206	0.0280569880638
ko04350	TGF-beta signaling pathway	9/1190	103/7206	0.0318043308351
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1190	92/7206	0.0334895190023
ko00860	Porphyrin and chlorophyll metabolism	1/1190	34/7206	0.0337548435005
ko03320	PPAR signaling pathway	5/1190	69/7206	0.0340508739743
ko04330	Notch signaling pathway	4/1190	62/7206	0.0370429099087
ko05145	Toxoplasmosis	12/1190	126/7206	0.0385143021189
ko04916	Melanogenesis	33/1190	142/7206	0.0389599331505
ko04930	Type II diabetes mellitus	15/1190	54/7206	0.0401902281423
ko04620	Toll-like receptor signaling pathway	9/1190	100/7206	0.0414549239824
ko05231	Choline metabolism in cancer	31/1190	134/7206	0.0451248683347
ko04114	Oocyte meiosis	32/1190	139/7206	0.0488178764559
ko05340	Primary immunodeficiency	1/1190	30/7206	0.0489487986739
ko04711	Circadian rhythm - fly	5/1190	13/7206	0.0492530193512