ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 57/527 152/7206 5.13800769085e-27 ko05033 Nicotine addiction 33/527 56/7206 8.17405126693e-24 ko04080 Neuroactive ligand-receptor interaction 90/527 423/7206 1.00209500725e-21 ko04728 Dopaminergic synapse 52/527 185/7206 3.16236258863e-18 ko04727 GABAergic synapse 38/527 110/7206 6.65571886005e-17 ko05032 Morphine addiction 38/527 110/7206 6.65571886005e-17 ko04721 Synaptic vesicle cycle 32/527 80/7206 1.44300063995e-16 ko04723 Retrograde endocannabinoid signaling 47/527 175/7206 1.02882283215e-15 ko04713 Circadian entrainment 39/527 136/7206 3.04525793635e-14 ko04024 cAMP signaling pathway 55/527 279/7206 4.67506449342e-12 ko04911 Insulin secretion 31/527 117/7206 1.34636870455e-10 ko04725 Cholinergic synapse 36/527 160/7206 6.44671464443e-10 ko05030 Cocaine addiction 23/527 73/7206 8.35220589291e-10 ko05031 Amphetamine addiction 25/527 91/7206 3.79260221111e-09 ko04726 Serotonergic synapse 30/527 137/7206 3.46911704339e-08 ko04514 Cell adhesion molecules (CAMs) 29/527 130/7206 3.81227212717e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 19/527 74/7206 9.11499977546e-07 ko04261 Adrenergic signaling in cardiomyocytes 35/527 205/7206 1.76851922902e-06 ko04720 Long-term potentiation 22/527 99/7206 1.83519160125e-06 ko04010 MAPK signaling pathway 46/527 321/7206 8.04535065291e-06 ko04060 Cytokine-cytokine receptor interaction 1/527 191/7206 1.36907495094e-05 ko04730 Long-term depression 17/527 78/7206 3.56814222424e-05 ko04020 Calcium signaling pathway 38/527 265/7206 5.35043485509e-05 ko04921 Oxytocin signaling pathway 31/527 209/7206 0.000125779317386 ko05203 Viral carcinogenesis 6/527 277/7206 0.000220320305674 ko03040 Spliceosome 1/527 145/7206 0.00030543504927 ko04742 Taste transduction 13/527 61/7206 0.000371212978489 ko04970 Salivary secretion 17/527 95/7206 0.000454901169968 ko05164 Influenza A 2/527 167/7206 0.000456233663358 ko04972 Pancreatic secretion 19/527 111/7206 0.000590628201167 ko04966 Collecting duct acid secretion 7/527 26/7206 0.00207585058802 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/527 14/7206 0.00235842792331 ko04140 Autophagy - animal 3/527 164/7206 0.00340929757303 ko05168 Herpes simplex infection 4/527 182/7206 0.0036535537242 ko04744 Phototransduction 8/527 36/7206 0.00376786325611 ko00512 Mucin type O-glycan biosynthesis 7/527 29/7206 0.00406705023954 ko04925 Aldosterone synthesis and secretion 16/527 105/7206 0.00408936672666 ko04120 Ubiquitin mediated proteolysis 2/527 138/7206 0.00421086436007 ko05322 Systemic lupus erythematosus 3/527 151/7206 0.00660443113688 ko05034 Alcoholism 29/527 238/7206 0.00720251607537 ko05205 Proteoglycans in cancer 9/527 271/7206 0.008330488173 ko04071 Sphingolipid signaling pathway 21/527 162/7206 0.00889102913445 ko04014 Ras signaling pathway 32/527 279/7206 0.00958423232864 ko04915 Estrogen signaling pathway 18/527 131/7206 0.00962607552967 ko04360 Axon guidance 28/527 233/7206 0.00974520206287 ko04022 cGMP-PKG signaling pathway 26/527 216/7206 0.0110173179176 ko05162 Measles 2/527 120/7206 0.0119002826814 ko04930 Type II diabetes mellitus 9/527 54/7206 0.0153848076429 ko05215 Prostate cancer 2/527 111/7206 0.0165542548284 ko04964 Proximal tubule bicarbonate reclamation 6/527 29/7206 0.016610948711 ko04630 Jak-STAT signaling pathway 3/527 132/7206 0.0178102234058 ko04621 NOD-like receptor signaling pathway 4/527 157/7206 0.0185875133081 ko04745 Phototransduction - fly 7/527 38/7206 0.018601536674 ko00240 Pyrimidine metabolism 2/527 110/7206 0.0242658048412 ko04072 Phospholipase D signaling pathway 23/527 197/7206 0.0251108998713 ko05169 Epstein-Barr virus infection 7/527 206/7206 0.0285518015739 ko05166 HTLV-I infection 12/527 292/7206 0.0289508535891 ko03008 Ribosome biogenesis in eukaryotes 1/527 79/7206 0.02913952786 ko04137 Mitophagy - animal 1/527 82/7206 0.02979413235 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/527 182/7206 0.0302836318439 ko04150 mTOR signaling pathway 6/527 184/7206 0.0304001992904 ko04971 Gastric acid secretion 13/527 98/7206 0.0304753464744 ko00513 Various types of N-glycan biosynthesis 7/527 42/7206 0.030943131663 ko04550 Signaling pathways regulating pluripotency of stem cells 5/527 165/7206 0.0325772691087 ko03013 RNA transport 5/527 166/7206 0.0328893362182 ko04540 Gap junction 16/527 128/7206 0.036994019062 ko00310 Lysine degradation 1/527 73/7206 0.0421717062039 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/527 92/7206 0.0423542926478 ko04612 Antigen processing and presentation 1/527 77/7206 0.04344915828 ko05110 Vibrio cholerae infection 9/527 63/7206 0.0465760003366 ko04740 Olfactory transduction 11/527 80/7206 0.0466653534471