ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 24/253 80/7206 1.17512275977e-16 ko04966 Collecting duct acid secretion 13/253 26/7206 6.28782411257e-13 ko04724 Glutamatergic synapse 27/253 152/7206 1.76143135836e-12 ko04713 Circadian entrainment 25/253 136/7206 5.57442828592e-12 ko04728 Dopaminergic synapse 27/253 185/7206 2.00818962319e-10 ko05031 Amphetamine addiction 18/253 91/7206 1.71212274027e-09 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/253 92/7206 2.06250552738e-09 ko05110 Vibrio cholerae infection 15/253 63/7206 2.71482737198e-09 ko04720 Long-term potentiation 18/253 99/7206 7.08098450459e-09 ko04145 Phagosome 23/253 162/7206 8.23769771345e-09 ko04626 Plant-pathogen interaction 8/253 18/7206 6.67342596445e-08 ko04911 Insulin secretion 18/253 117/7206 1.06046818863e-07 ko00190 Oxidative phosphorylation 18/253 127/7206 3.79432971843e-07 ko05033 Nicotine addiction 12/253 56/7206 3.81683783826e-07 ko04261 Adrenergic signaling in cardiomyocytes 23/253 205/7206 6.83081977101e-07 ko04080 Neuroactive ligand-receptor interaction 35/253 423/7206 1.65615340058e-06 ko05323 Rheumatoid arthritis 14/253 89/7206 2.18725292405e-06 ko04725 Cholinergic synapse 19/253 160/7206 2.83925863669e-06 ko04024 cAMP signaling pathway 26/253 279/7206 4.45403033455e-06 ko04745 Phototransduction - fly 9/253 38/7206 4.69459836377e-06 ko04971 Gastric acid secretion 14/253 98/7206 7.04745473366e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 12/253 74/7206 8.54387022953e-06 ko04970 Salivary secretion 13/253 95/7206 2.41889648531e-05 ko04727 GABAergic synapse 14/253 110/7206 2.72288990881e-05 ko04723 Retrograde endocannabinoid signaling 18/253 175/7206 3.835417703e-05 ko04114 Oocyte meiosis 15/253 139/7206 9.93152457677e-05 ko04726 Serotonergic synapse 14/253 137/7206 0.00030112818631 ko04730 Long-term depression 10/253 78/7206 0.000365605315246 ko04921 Oxytocin signaling pathway 18/253 209/7206 0.000373461005895 ko04964 Proximal tubule bicarbonate reclamation 6/253 29/7206 0.000424527591636 ko04924 Renin secretion 10/253 86/7206 0.000804453313743 ko05152 Tuberculosis 16/253 187/7206 0.000845485023808 ko05030 Cocaine addiction 9/253 73/7206 0.000956476123506 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/253 59/7206 0.000970912947121 ko04744 Phototransduction 6/253 36/7206 0.00141693035839 ko04360 Axon guidance 18/253 233/7206 0.00155476504383 ko05032 Morphine addiction 11/253 110/7206 0.00158302828788 ko05034 Alcoholism 18/253 238/7206 0.00188307322542 ko04014 Ras signaling pathway 20/253 279/7206 0.00227769297522 ko05010 Alzheimer's disease 16/253 202/7206 0.00256885141482 ko04912 GnRH signaling pathway 11/253 122/7206 0.0036012350625 ko04022 cGMP-PKG signaling pathway 16/253 216/7206 0.00414194114541 ko04016 MAPK signaling pathway - plant 4/253 20/7206 0.00461054524597 ko04940 Type I diabetes mellitus 5/253 32/7206 0.00474786575677 ko04922 Glucagon signaling pathway 11/253 128/7206 0.00519403403046 ko04972 Pancreatic secretion 10/253 111/7206 0.00544779129746 ko04020 Calcium signaling pathway 18/253 265/7206 0.00613061322498 ko05214 Glioma 8/253 79/7206 0.00625862245526 ko04740 Olfactory transduction 8/253 80/7206 0.00674889786788 ko04260 Cardiac muscle contraction 9/253 98/7206 0.00725935736597 ko04750 Inflammatory mediator regulation of TRP channels 10/253 122/7206 0.0104229206526 ko04371 Apelin signaling pathway 13/253 177/7206 0.0108972803582 ko04978 Mineral absorption 5/253 40/7206 0.0123619890626 ko04722 Neurotrophin signaling pathway 12/253 160/7206 0.0134874038445 ko04960 Aldosterone-regulated sodium reabsorption 5/253 41/7206 0.0136865246352 ko05166 HTLV-I infection 3/253 292/7206 0.0137748368367 ko04973 Carbohydrate digestion and absorption 5/253 42/7206 0.0151034511916 ko04370 VEGF signaling pathway 7/253 77/7206 0.0180007738137 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/253 191/7206 0.0247551810312 ko04514 Cell adhesion molecules (CAMs) 10/253 130/7206 0.0250001933966 ko04015 Rap1 signaling pathway 17/253 278/7206 0.0282614116237 ko04925 Aldosterone synthesis and secretion 8/253 105/7206 0.0308589257612 ko05164 Influenza A 1/253 167/7206 0.0315043160405 ko04916 Melanogenesis 10/253 142/7206 0.0333604328762 ko04662 B cell receptor signaling pathway 7/253 88/7206 0.0344552794258 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/253 1/7206 0.0351096308633 ko04010 MAPK signaling pathway 18/253 321/7206 0.043183814178 ko04540 Gap junction 9/253 128/7206 0.0456234251033