ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 54/521 191/7206 2.98176652579e-19 ko04380 Osteoclast differentiation 38/521 134/7206 6.77528551133e-14 ko04621 NOD-like receptor signaling pathway 41/521 157/7206 1.44870797683e-13 ko05164 Influenza A 42/521 167/7206 2.91671851599e-13 ko04650 Natural killer cell mediated cytotoxicity 30/521 97/7206 2.70007259651e-12 ko05340 Primary immunodeficiency 16/521 30/7206 2.5098347107e-11 ko05162 Measles 32/521 120/7206 4.13785983666e-11 ko05330 Allograft rejection 14/521 24/7206 8.99902667768e-11 ko05321 Inflammatory bowel disease (IBD) 21/521 56/7206 9.16743497291e-11 ko05145 Toxoplasmosis 32/521 126/7206 1.65710086408e-10 ko05140 Leishmaniasis 24/521 75/7206 1.95369184324e-10 ko04217 Necroptosis 39/521 178/7206 2.0023428398e-10 ko04620 Toll-like receptor signaling pathway 27/521 100/7206 1.05644253413e-09 ko04064 NF-kappa B signaling pathway 26/521 96/7206 2.01443503262e-09 ko05320 Autoimmune thyroid disease 14/521 29/7206 2.53436397558e-09 ko05332 Graft-versus-host disease 11/521 18/7206 5.0872587971e-09 ko05150 Staphylococcus aureus infection 15/521 36/7206 8.50087379959e-09 ko04640 Hematopoietic cell lineage 20/521 64/7206 1.0352605053e-08 ko04612 Antigen processing and presentation 22/521 77/7206 1.21880749286e-08 ko05168 Herpes simplex infection 36/521 182/7206 1.86022141528e-08 ko04660 T cell receptor signaling pathway 28/521 124/7206 3.88885912089e-08 ko05152 Tuberculosis 36/521 187/7206 3.89249342885e-08 ko04659 Th17 cell differentiation 25/521 106/7206 8.49983925352e-08 ko04672 Intestinal immune network for IgA production 14/521 37/7206 1.16026238986e-07 ko04630 Jak-STAT signaling pathway 27/521 132/7206 5.7936636303e-07 ko05310 Asthma 9/521 17/7206 7.25544431049e-07 ko05144 Malaria 14/521 45/7206 1.84533590454e-06 ko04658 Th1 and Th2 cell differentiation 21/521 96/7206 3.43034454452e-06 ko04940 Type I diabetes mellitus 11/521 32/7206 8.09392279421e-06 ko04062 Chemokine signaling pathway 33/521 201/7206 9.95580841173e-06 ko04662 B cell receptor signaling pathway 19/521 88/7206 1.22401152442e-05 ko05142 Chagas disease (American trypanosomiasis) 24/521 130/7206 1.57744924185e-05 ko04622 RIG-I-like receptor signaling pathway 15/521 62/7206 2.43758122389e-05 ko04610 Complement and coagulation cascades 17/521 79/7206 3.66784334953e-05 ko05133 Pertussis 18/521 87/7206 3.80909553611e-05 ko00120 Primary bile acid biosynthesis 8/521 20/7206 4.09293418824e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/521 191/7206 4.67659092309e-05 ko05323 Rheumatoid arthritis 18/521 89/7206 5.2395079195e-05 ko00590 Arachidonic acid metabolism 13/521 52/7206 5.8631839772e-05 ko03013 RNA transport 1/521 166/7206 9.84362746086e-05 ko04210 Apoptosis 28/521 180/7206 0.000101064974104 ko04623 Cytosolic DNA-sensing pathway 11/521 41/7206 0.000108983834276 ko04310 Wnt signaling pathway 2/521 181/7206 0.000218486566141 ko04611 Platelet activation 25/521 163/7206 0.000308426538502 ko04668 TNF signaling pathway 20/521 120/7206 0.000452589769346 ko03040 Spliceosome 1/521 145/7206 0.000475654428069 ko04666 Fc gamma R-mediated phagocytosis 20/521 122/7206 0.000521542360901 ko04137 Mitophagy - animal 15/521 82/7206 0.000678781468009 ko05161 Hepatitis B 25/521 173/7206 0.000841757954769 ko04390 Hippo signaling pathway 3/521 188/7206 0.000847817378535 ko03010 Ribosome 1/521 129/7206 0.00152614661783 ko05143 African trypanosomiasis 8/521 32/7206 0.00157625763272 ko00592 alpha-Linolenic acid metabolism 6/521 19/7206 0.00166869395107 ko04145 Phagosome 23/521 162/7206 0.00174633878837 ko05034 Alcoholism 6/521 238/7206 0.00208408151498 ko05160 Hepatitis C 22/521 153/7206 0.00218530723328 ko05146 Amoebiasis 16/521 99/7206 0.00237842549044 ko04916 Melanogenesis 2/521 142/7206 0.00283500379044 ko04110 Cell cycle 2/521 145/7206 0.00294091578648 ko04664 Fc epsilon RI signaling pathway 13/521 77/7206 0.00320523516634 ko05418 Fluid shear stress and atherosclerosis 23/521 173/7206 0.00417790307857 ko03050 Proteasome 10/521 54/7206 0.00473672307405 ko04080 Neuroactive ligand-receptor interaction 17/521 423/7206 0.00655258005608 ko00140 Steroid hormone biosynthesis 8/521 41/7206 0.0080631860159 ko01524 Platinum drug resistance 12/521 76/7206 0.0111020235676 ko04146 Peroxisome 13/521 89/7206 0.012309785712 ko04728 Dopaminergic synapse 5/521 185/7206 0.0134559603294 ko03015 mRNA surveillance pathway 1/521 93/7206 0.0139982370848 ko04068 FoxO signaling pathway 21/521 167/7206 0.014177957075 ko00982 Drug metabolism - cytochrome P450 7/521 37/7206 0.0152481079819 ko04514 Cell adhesion molecules (CAMs) 17/521 130/7206 0.0154341883551 ko05132 Salmonella infection 14/521 98/7206 0.0157105717957 ko05416 Viral myocarditis 9/521 55/7206 0.0161043421281 ko04911 Insulin secretion 2/521 117/7206 0.0172434625843 ko04723 Retrograde endocannabinoid signaling 5/521 175/7206 0.0178583590125 ko04360 Axon guidance 8/521 233/7206 0.0199747802044 ko05134 Legionellosis 11/521 74/7206 0.0203023164635 ko04391 Hippo signaling pathway - fly 1/521 90/7206 0.0212039506804 ko00980 Metabolism of xenobiotics by cytochrome P450 7/521 40/7206 0.0229158453547 ko05224 Breast cancer 5/521 174/7206 0.0246479669584 ko04530 Tight junction 8/521 228/7206 0.0262044368001 ko00350 Tyrosine metabolism 6/521 33/7206 0.0288105556617 ko04740 Olfactory transduction 1/521 80/7206 0.0291990952484 ko00051 Fructose and mannose metabolism 7/521 42/7206 0.029298885602 ko00360 Phenylalanine metabolism 4/521 17/7206 0.0301889279016 ko00950 Isoquinoline alkaloid biosynthesis 3/521 10/7206 0.0307391989196 ko03320 PPAR signaling pathway 10/521 69/7206 0.0310637124933 ko04670 Leukocyte transendothelial migration 18/521 151/7206 0.0366866439802 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/521 5/7206 0.0450602188499 ko04114 Oocyte meiosis 4/521 139/7206 0.045618754062