ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1110	423/7206	1.66487132161e-54
ko04724	Glutamatergic synapse	86/1110	152/7206	2.97381717574e-32
ko05033	Nicotine addiction	47/1110	56/7206	5.24858321087e-30
ko05032	Morphine addiction	64/1110	110/7206	3.66972783956e-25
ko04713	Circadian entrainment	71/1110	136/7206	6.37229842332e-24
ko04721	Synaptic vesicle cycle	50/1110	80/7206	7.41799635224e-22
ko04727	GABAergic synapse	60/1110	110/7206	1.14703392581e-21
ko04728	Dopaminergic synapse	82/1110	185/7206	1.88009802546e-21
ko04725	Cholinergic synapse	74/1110	160/7206	8.53209283354e-21
ko04024	cAMP signaling pathway	102/1110	279/7206	8.08085935069e-19
ko04723	Retrograde endocannabinoid signaling	74/1110	175/7206	5.01768390903e-18
ko04020	Calcium signaling pathway	96/1110	265/7206	1.7730074396e-17
ko04726	Serotonergic synapse	61/1110	137/7206	2.38974275505e-16
ko04742	Taste transduction	37/1110	61/7206	7.09758609036e-16
ko04911	Insulin secretion	53/1110	117/7206	9.51724559257e-15
ko04921	Oxytocin signaling pathway	76/1110	209/7206	5.11190541262e-14
ko04720	Long-term potentiation	44/1110	99/7206	4.15346138029e-12
ko04744	Phototransduction	24/1110	36/7206	4.91827722817e-12
ko05031	Amphetamine addiction	40/1110	91/7206	6.06925849062e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1110	205/7206	3.73881289815e-10
ko03040	Spliceosome	1/1110	145/7206	1.41125485898e-09
ko04360	Axon guidance	71/1110	233/7206	3.21310497324e-09
ko04740	Olfactory transduction	34/1110	80/7206	4.90560101796e-09
ko04970	Salivary secretion	37/1110	95/7206	1.80462337629e-08
ko05168	Herpes simplex infection	5/1110	182/7206	3.04036781009e-08
ko05203	Viral carcinogenesis	14/1110	277/7206	6.13911058147e-08
ko05030	Cocaine addiction	30/1110	73/7206	9.86775386429e-08
ko04060	Cytokine-cytokine receptor interaction	7/1110	191/7206	2.32440313904e-07
ko05164	Influenza A	6/1110	167/7206	1.20899498456e-06
ko04925	Aldosterone synthesis and secretion	36/1110	105/7206	1.55903000355e-06
ko04010	MAPK signaling pathway	82/1110	321/7206	1.62252719063e-06
ko04971	Gastric acid secretion	34/1110	98/7206	1.72611069497e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1110	74/7206	1.94202788445e-06
ko05322	Systemic lupus erythematosus	5/1110	151/7206	2.04774477477e-06
ko04022	cGMP-PKG signaling pathway	59/1110	216/7206	5.15743824144e-06
ko04621	NOD-like receptor signaling pathway	6/1110	157/7206	5.29663307553e-06
ko03013	RNA transport	7/1110	166/7206	6.12113990078e-06
ko04514	Cell adhesion molecules (CAMs)	39/1110	130/7206	2.11899828867e-05
ko04730	Long-term depression	27/1110	78/7206	2.22196628937e-05
ko04924	Renin secretion	29/1110	86/7206	2.65716456486e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1110	79/7206	2.79782897472e-05
ko04540	Gap junction	38/1110	128/7206	3.36332409733e-05
ko04966	Collecting duct acid secretion	13/1110	26/7206	3.73709037482e-05
ko04260	Cardiac muscle contraction	31/1110	98/7206	5.11158322825e-05
ko04610	Complement and coagulation cascades	1/1110	79/7206	5.25322624184e-05
ko04120	Ubiquitin mediated proteolysis	6/1110	138/7206	6.54458493582e-05
ko04745	Phototransduction - fly	16/1110	38/7206	6.93945549084e-05
ko05169	Epstein-Barr virus infection	13/1110	206/7206	7.76964921115e-05
ko04110	Cell cycle	7/1110	145/7206	0.000100789799273
ko04141	Protein processing in endoplasmic reticulum	11/1110	184/7206	0.00011038361592
ko04014	Ras signaling pathway	67/1110	279/7206	0.000126471802344
ko04972	Pancreatic secretion	33/1110	111/7206	0.000152502189913
ko04070	Phosphatidylinositol signaling system	32/1110	112/7206	0.000310200764163
ko05110	Vibrio cholerae infection	21/1110	63/7206	0.000327005580643
ko03008	Ribosome biogenesis in eukaryotes	2/1110	79/7206	0.000414681810485
ko05162	Measles	6/1110	120/7206	0.000517286516146
ko05140	Leishmaniasis	2/1110	75/7206	0.000594812867713
ko04612	Antigen processing and presentation	2/1110	77/7206	0.000634550124613
ko05414	Dilated cardiomyopathy	31/1110	112/7206	0.000815321145454
ko04064	NF-kappa B signaling pathway	4/1110	96/7206	0.000886080053273
ko05161	Hepatitis B	12/1110	173/7206	0.000894291799406
ko04371	Apelin signaling pathway	44/1110	177/7206	0.000972746391622
ko05205	Proteoglycans in cancer	24/1110	271/7206	0.00147017827387
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1110	59/7206	0.00152018461979
ko04072	Phospholipase D signaling pathway	47/1110	197/7206	0.00177234356591
ko00480	Glutathione metabolism	1/1110	55/7206	0.00210146037554
ko04750	Inflammatory mediator regulation of TRP channels	32/1110	122/7206	0.00210991246909
ko05166	HTLV-I infection	27/1110	292/7206	0.00212255491295
ko04976	Bile secretion	23/1110	80/7206	0.00255417390095
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1110	14/7206	0.00255762572918
ko04146	Peroxisome	4/1110	89/7206	0.0026605042305
ko04640	Hematopoietic cell lineage	2/1110	64/7206	0.00278185883882
ko00590	Arachidonic acid metabolism	1/1110	52/7206	0.00311797964812
ko04915	Estrogen signaling pathway	33/1110	131/7206	0.0031401246269
ko04626	Plant-pathogen interaction	8/1110	18/7206	0.0031885917927
ko00330	Arginine and proline metabolism	2/1110	61/7206	0.00407826075723
ko04330	Notch signaling pathway	2/1110	62/7206	0.00408752238613
ko04214	Apoptosis - fly	3/1110	72/7206	0.00472609588071
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1110	182/7206	0.00484847187839
ko00240	Pyrimidine metabolism	7/1110	110/7206	0.00506727811029
ko03420	Nucleotide excision repair	1/1110	46/7206	0.00691837657691
ko00260	Glycine, serine and threonine metabolism	1/1110	48/7206	0.00743062185845
ko05321	Inflammatory bowel disease (IBD)	2/1110	56/7206	0.0086464257734
ko04964	Proximal tubule bicarbonate reclamation	10/1110	29/7206	0.00881663950901
ko01524	Platinum drug resistance	4/1110	76/7206	0.00999925921855
ko04630	Jak-STAT signaling pathway	10/1110	132/7206	0.0101180357266
ko04657	IL-17 signaling pathway	5/1110	87/7206	0.0101828867706
ko05418	Fluid shear stress and atherosclerosis	15/1110	173/7206	0.0103968063149
ko03022	Basal transcription factors	1/1110	44/7206	0.0104393473234
ko05144	Malaria	1/1110	45/7206	0.0108681829013
ko00071	Fatty acid degradation	1/1110	45/7206	0.0108681829013
ko00562	Inositol phosphate metabolism	23/1110	89/7206	0.0110044815658
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1110	100/7206	0.011401312645
ko00280	Valine, leucine and isoleucine degradation	2/1110	54/7206	0.0126434597496
ko00561	Glycerolipid metabolism	3/1110	63/7206	0.0136423851318
ko00310	Lysine degradation	4/1110	73/7206	0.0139614328163
ko03018	RNA degradation	5/1110	84/7206	0.0139684549594
ko04668	TNF signaling pathway	9/1110	120/7206	0.0146474115134
ko04217	Necroptosis	16/1110	178/7206	0.015189008436
ko04912	GnRH signaling pathway	29/1110	122/7206	0.0154209813766
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1110	40/7206	0.0154511540071
ko00983	Drug metabolism - other enzymes	1/1110	42/7206	0.0159351279497
ko05145	Toxoplasmosis	10/1110	126/7206	0.0174337274071
ko00380	Tryptophan metabolism	2/1110	50/7206	0.0182180200057
ko05131	Shigellosis	5/1110	82/7206	0.0195639928906
ko04622	RIG-I-like receptor signaling pathway	3/1110	62/7206	0.0198261614511
ko04930	Type II diabetes mellitus	15/1110	54/7206	0.0207836711492
ko04015	Rap1 signaling pathway	57/1110	278/7206	0.02174432418
ko04658	Th1 and Th2 cell differentiation	7/1110	96/7206	0.022653602347
ko03410	Base excision repair	1/1110	38/7206	0.02293238102
ko05133	Pertussis	6/1110	87/7206	0.0243662664151
ko04350	TGF-beta signaling pathway	8/1110	103/7206	0.0275879586011
ko05034	Alcoholism	49/1110	238/7206	0.028211703561
ko04115	p53 signaling pathway	5/1110	74/7206	0.0351722478767
ko00982	Drug metabolism - cytochrome P450	1/1110	37/7206	0.0357658073828
ko04620	Toll-like receptor signaling pathway	8/1110	100/7206	0.0363172339282
ko00620	Pyruvate metabolism	2/1110	46/7206	0.0381106142628
ko00270	Cysteine and methionine metabolism	2/1110	47/7206	0.0393029789594
ko04916	Melanogenesis	31/1110	142/7206	0.0448106574972
ko04722	Neurotrophin signaling pathway	34/1110	160/7206	0.0455677365121