ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 52/269 423/7206 6.20701840631e-15 ko05033 Nicotine addiction 19/269 56/7206 4.83520427329e-14 ko04724 Glutamatergic synapse 28/269 152/7206 1.20001957848e-12 ko04728 Dopaminergic synapse 28/269 185/7206 1.61077229476e-10 ko05014 Amyotrophic lateral sclerosis (ALS) 16/269 74/7206 8.74877348287e-09 ko04713 Circadian entrainment 21/269 136/7206 2.44549339722e-08 ko05031 Amphetamine addiction 17/269 91/7206 3.06734857201e-08 ko04727 GABAergic synapse 18/269 110/7206 1.01812191675e-07 ko05030 Cocaine addiction 13/269 73/7206 2.37316703099e-06 ko04024 cAMP signaling pathway 27/269 279/7206 4.53199486272e-06 ko04721 Synaptic vesicle cycle 13/269 80/7206 6.85926547845e-06 ko04723 Retrograde endocannabinoid signaling 20/269 175/7206 7.18999687886e-06 ko04725 Cholinergic synapse 18/269 160/7206 2.5873716134e-05 ko05032 Morphine addiction 14/269 110/7206 5.35899260277e-05 ko04911 Insulin secretion 14/269 117/7206 0.000106141070637 ko04740 Olfactory transduction 11/269 80/7206 0.000169634713891 ko04974 Protein digestion and absorption 12/269 96/7206 0.000217924195998 ko04261 Adrenergic signaling in cardiomyocytes 19/269 205/7206 0.000219074002474 ko04730 Long-term depression 10/269 78/7206 0.000593610503806 ko04260 Cardiac muscle contraction 11/269 98/7206 0.00100167742628 ko04720 Long-term potentiation 11/269 99/7206 0.00109039625373 ko04921 Oxytocin signaling pathway 17/269 209/7206 0.00232890475045 ko04970 Salivary secretion 10/269 95/7206 0.00273410616183 ko04514 Cell adhesion molecules (CAMs) 12/269 130/7206 0.00326561573403 ko04978 Mineral absorption 6/269 40/7206 0.00337323294011 ko04924 Renin secretion 9/269 86/7206 0.00457745272654 ko04726 Serotonergic synapse 12/269 137/7206 0.00500224829618 ko04010 MAPK signaling pathway 22/269 321/7206 0.00587859247113 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/269 59/7206 0.00605685799851 ko00350 Tyrosine metabolism 5/269 33/7206 0.00703149537099 ko04512 ECM-receptor interaction 8/269 79/7206 0.00894353556847 ko04976 Bile secretion 8/269 80/7206 0.0096258738786 ko04060 Cytokine-cytokine receptor interaction 1/269 191/7206 0.0105147396624 ko04020 Calcium signaling pathway 18/269 265/7206 0.0123831025983 ko05168 Herpes simplex infection 1/269 182/7206 0.0153886896932 ko04964 Proximal tubule bicarbonate reclamation 4/269 29/7206 0.021625223786 ko04742 Taste transduction 6/269 61/7206 0.0255158134322 ko04140 Autophagy - animal 1/269 164/7206 0.0330661626797 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/269 1/7206 0.0373300027754 ko05322 Systemic lupus erythematosus 1/269 151/7206 0.0464161640507 ko04150 mTOR signaling pathway 2/269 184/7206 0.0489929883223