ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 38/631 152/7206 1.49289120858e-09 ko04080 Neuroactive ligand-receptor interaction 71/631 423/7206 4.09924050893e-08 ko04713 Circadian entrainment 32/631 136/7206 1.40272917076e-07 ko05033 Nicotine addiction 18/631 56/7206 6.38929065874e-07 ko04725 Cholinergic synapse 34/631 160/7206 1.12114763212e-06 ko04728 Dopaminergic synapse 37/631 185/7206 1.85934906134e-06 ko04727 GABAergic synapse 26/631 110/7206 1.91925160766e-06 ko04911 Insulin secretion 27/631 117/7206 2.00686771694e-06 ko04020 Calcium signaling pathway 47/631 265/7206 2.1037177798e-06 ko05032 Morphine addiction 25/631 110/7206 6.41807799269e-06 ko04726 Serotonergic synapse 28/631 137/7206 1.88228606898e-05 ko04974 Protein digestion and absorption 22/631 96/7206 1.99566018223e-05 ko05322 Systemic lupus erythematosus 1/631 151/7206 2.74133185597e-05 ko05203 Viral carcinogenesis 7/631 277/7206 3.02608696296e-05 ko04721 Synaptic vesicle cycle 19/631 80/7206 4.30850571173e-05 ko04745 Phototransduction - fly 12/631 38/7206 5.88428802524e-05 ko04120 Ubiquitin mediated proteolysis 1/631 138/7206 9.12665040831e-05 ko04976 Bile secretion 18/631 80/7206 0.000144145167762 ko00120 Primary bile acid biosynthesis 8/631 20/7206 0.000160837126589 ko04514 Cell adhesion molecules (CAMs) 25/631 130/7206 0.000208557313658 ko04710 Circadian rhythm 12/631 43/7206 0.000221662511776 ko05031 Amphetamine addiction 19/631 91/7206 0.00026955740939 ko05169 Epstein-Barr virus infection 5/631 206/7206 0.000376512134359 ko04971 Gastric acid secretion 20/631 98/7206 0.000376961427644 ko04024 cAMP signaling pathway 42/631 279/7206 0.000472714516938 ko04964 Proximal tubule bicarbonate reclamation 9/631 29/7206 0.000576987105688 ko04723 Retrograde endocannabinoid signaling 29/631 175/7206 0.000640552503876 ko04925 Aldosterone synthesis and secretion 20/631 105/7206 0.000727779426477 ko05166 HTLV-I infection 11/631 292/7206 0.000982788424986 ko04070 Phosphatidylinositol signaling system 21/631 112/7206 0.000996258060493 ko03013 RNA transport 4/631 166/7206 0.00127078818552 ko05164 Influenza A 4/631 167/7206 0.00127230544096 ko04141 Protein processing in endoplasmic reticulum 5/631 184/7206 0.00137845755123 ko04970 Salivary secretion 18/631 95/7206 0.00145460432818 ko04110 Cell cycle 3/631 145/7206 0.0015803598781 ko04972 Pancreatic secretion 20/631 111/7206 0.00179050830032 ko05168 Herpes simplex infection 5/631 182/7206 0.00195828877179 ko04960 Aldosterone-regulated sodium reabsorption 10/631 41/7206 0.00227122189914 ko04621 NOD-like receptor signaling pathway 4/631 157/7206 0.00248813995653 ko00643 Styrene degradation 3/631 4/7206 0.00249924764135 ko05162 Measles 2/631 120/7206 0.00277586268085 ko04744 Phototransduction 9/631 36/7206 0.00311334628286 ko04720 Long-term potentiation 18/631 99/7206 0.00325549403514 ko04966 Collecting duct acid secretion 7/631 26/7206 0.00573122497982 ko00350 Tyrosine metabolism 8/631 33/7206 0.00639154778606 ko04261 Adrenergic signaling in cardiomyocytes 29/631 205/7206 0.00830469827011 ko04810 Regulation of actin cytoskeleton 12/631 264/7206 0.0105158380685 ko04620 Toll-like receptor signaling pathway 2/631 100/7206 0.0113226148533 ko04921 Oxytocin signaling pathway 29/631 209/7206 0.0123415166565 ko04380 Osteoclast differentiation 4/631 134/7206 0.0127607341106 ko04612 Antigen processing and presentation 1/631 77/7206 0.0133674340103 ko05205 Proteoglycans in cancer 13/631 271/7206 0.0156937850952 ko05211 Renal cell carcinoma 2/631 96/7206 0.0162841844803 ko04626 Plant-pathogen interaction 5/631 18/7206 0.0165816246832 ko04022 cGMP-PKG signaling pathway 29/631 216/7206 0.0194562123763 ko05200 Pathways in cancer 29/631 492/7206 0.0203186550589 ko04711 Circadian rhythm - fly 4/631 13/7206 0.0219459525934 ko04730 Long-term depression 13/631 78/7206 0.0235268980768 ko04660 T cell receptor signaling pathway 4/631 124/7206 0.0238908015842 ko00830 Retinol metabolism 8/631 42/7206 0.027103157495 ko00051 Fructose and mannose metabolism 8/631 42/7206 0.027103157495 ko05016 Huntington's disease 10/631 215/7206 0.0271953896678 ko05161 Hepatitis B 7/631 173/7206 0.0279811607796 ko05220 Chronic myeloid leukemia 2/631 85/7206 0.031961703916 ko04657 IL-17 signaling pathway 2/631 87/7206 0.0328650651882 ko05030 Cocaine addiction 12/631 73/7206 0.0333787355853 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/631 59/7206 0.0350645497 ko04510 Focal adhesion 12/631 240/7206 0.0359008763607 ko04622 RIG-I-like receptor signaling pathway 1/631 62/7206 0.0407935201357 ko05212 Pancreatic cancer 2/631 83/7206 0.0469585888779 ko03320 PPAR signaling pathway 11/631 69/7206 0.0495283445975