ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	101/946	145/7206	8.79187678737e-57
ko03013	RNA transport	79/946	166/7206	7.69947091175e-28
ko04080	Neuroactive ligand-receptor interaction	3/946	423/7206	2.12354778379e-22
ko03008	Ribosome biogenesis in eukaryotes	46/946	79/7206	2.54317081057e-21
ko03030	DNA replication	30/946	38/7206	3.99585865358e-20
ko04110	Cell cycle	63/946	145/7206	8.67433549393e-20
ko04111	Cell cycle - yeast	47/946	90/7206	4.36540731366e-19
ko03015	mRNA surveillance pathway	41/946	93/7206	1.48015688619e-13
ko04113	Meiosis - yeast	34/946	70/7206	5.85952580095e-13
ko04020	Calcium signaling pathway	3/946	265/7206	6.76520542178e-13
ko00240	Pyrimidine metabolism	43/946	110/7206	5.51173116513e-12
ko03460	Fanconi anemia pathway	26/946	51/7206	8.0932072067e-11
ko04144	Endocytosis	11/946	342/7206	2.11578072025e-10
ko03430	Mismatch repair	16/946	22/7206	2.38714703406e-10
ko05010	Alzheimer's disease	2/946	202/7206	2.47269981763e-10
ko03410	Base excision repair	21/946	38/7206	7.7657742493e-10
ko03050	Proteasome	25/946	54/7206	2.54080638396e-09
ko03020	RNA polymerase	17/946	29/7206	9.8359785287e-09
ko04723	Retrograde endocannabinoid signaling	2/946	175/7206	1.01778002884e-08
ko04724	Glutamatergic synapse	1/946	152/7206	1.59336220296e-08
ko03018	RNA degradation	31/946	84/7206	2.61721973012e-08
ko04921	Oxytocin signaling pathway	5/946	209/7206	6.15127156076e-08
ko03420	Nucleotide excision repair	21/946	46/7206	6.59236542137e-08
ko05217	Basal cell carcinoma	26/946	68/7206	1.53438783717e-07
ko05012	Parkinson's disease	2/946	155/7206	1.87047751436e-07
ko03440	Homologous recombination	19/946	41/7206	2.09016153673e-07
ko04725	Cholinergic synapse	3/946	160/7206	6.50337872358e-07
ko04022	cGMP-PKG signaling pathway	7/946	216/7206	9.57407600908e-07
ko04621	NOD-like receptor signaling pathway	3/946	157/7206	9.63596045779e-07
ko04726	Serotonergic synapse	2/946	137/7206	1.30835018782e-06
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/946	182/7206	1.8633030972e-06
ko04915	Estrogen signaling pathway	2/946	131/7206	2.90517495056e-06
ko04024	cAMP signaling pathway	13/946	279/7206	3.00862096037e-06
ko04727	GABAergic synapse	1/946	110/7206	5.38996823244e-06
ko05032	Morphine addiction	1/946	110/7206	5.38996823244e-06
ko00230	Purine metabolism	48/946	194/7206	1.15351532976e-05
ko04261	Adrenergic signaling in cardiomyocytes	8/946	205/7206	1.24459305034e-05
ko05169	Epstein-Barr virus infection	50/946	206/7206	1.2905814709e-05
ko04713	Circadian entrainment	3/946	136/7206	1.47734601524e-05
ko04062	Chemokine signaling pathway	8/946	201/7206	1.71801664598e-05
ko03022	Basal transcription factors	17/946	44/7206	1.87301732624e-05
ko04650	Natural killer cell mediated cytotoxicity	1/946	97/7206	2.747281827e-05
ko04260	Cardiac muscle contraction	1/946	98/7206	2.79431655367e-05
ko04971	Gastric acid secretion	1/946	98/7206	2.79431655367e-05
ko03010	Ribosome	3/946	129/7206	3.09206676441e-05
ko04070	Phosphatidylinositol signaling system	2/946	112/7206	3.13063727226e-05
ko05414	Dilated cardiomyopathy	2/946	112/7206	3.13063727226e-05
ko04970	Salivary secretion	1/946	95/7206	4.21028263727e-05
ko04060	Cytokine-cytokine receptor interaction	8/946	191/7206	4.6952357236e-05
ko04270	Vascular smooth muscle contraction	5/946	154/7206	5.01271637684e-05
ko04371	Apelin signaling pathway	7/946	177/7206	6.22678198351e-05
ko04912	GnRH signaling pathway	3/946	122/7206	6.51768166726e-05
ko04728	Dopaminergic synapse	8/946	185/7206	9.18120219909e-05
ko04920	Adipocytokine signaling pathway	1/946	89/7206	9.54027468639e-05
ko04911	Insulin secretion	3/946	117/7206	0.000141503388881
ko04924	Renin secretion	1/946	86/7206	0.000143467774818
ko05410	Hypertrophic cardiomyopathy (HCM)	2/946	100/7206	0.000148374796046
ko04540	Gap junction	4/946	128/7206	0.000171497873296
ko04730	Long-term depression	1/946	78/7206	0.000314792661829
ko04610	Complement and coagulation cascades	1/946	79/7206	0.000315085411495
ko04974	Protein digestion and absorption	2/946	96/7206	0.000336884337947
ko04010	MAPK signaling pathway	22/946	321/7206	0.00035386188986
ko04330	Notch signaling pathway	19/946	62/7206	0.000397867502178
ko04380	Osteoclast differentiation	5/946	134/7206	0.00040155770258
ko04933	AGE-RAGE signaling pathway in diabetic complications	5/946	135/7206	0.000413103051403
ko04659	Th17 cell differentiation	3/946	106/7206	0.000419426309469
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/946	92/7206	0.000478848877346
ko04630	Jak-STAT signaling pathway	5/946	132/7206	0.000586618467328
ko04510	Focal adhesion	15/946	240/7206	0.000634179098621
ko04925	Aldosterone synthesis and secretion	3/946	105/7206	0.000634393873329
ko04662	B cell receptor signaling pathway	2/946	88/7206	0.00069139426485
ko00562	Inositol phosphate metabolism	2/946	89/7206	0.000704051315086
ko05030	Cocaine addiction	1/946	73/7206	0.000706442302623
ko00010	Glycolysis / Gluconeogenesis	1/946	74/7206	0.000728352541619
ko04310	Wnt signaling pathway	40/946	181/7206	0.000733429094686
ko04720	Long-term potentiation	3/946	99/7206	0.000874935583096
ko04611	Platelet activation	8/946	163/7206	0.000886870186212
ko04972	Pancreatic secretion	4/946	111/7206	0.00101009114889
ko05322	Systemic lupus erythematosus	34/946	151/7206	0.00135987725834
ko04138	Autophagy - yeast	2/946	81/7206	0.00147706953739
ko04668	TNF signaling pathway	5/946	120/7206	0.00154443126669
ko04750	Inflammatory mediator regulation of TRP channels	5/946	122/7206	0.0015988179046
ko04072	Phospholipase D signaling pathway	12/946	197/7206	0.00179806538841
ko05166	HTLV-I infection	57/946	292/7206	0.00184398052779
ko04530	Tight junction	15/946	228/7206	0.00188556789074
ko05160	Hepatitis C	8/946	153/7206	0.00223010106967
ko05142	Chagas disease (American trypanosomiasis)	6/946	130/7206	0.00226956728406
ko04640	Hematopoietic cell lineage	1/946	64/7206	0.00235641105253
ko04151	PI3K-Akt signaling pathway	32/946	390/7206	0.00253984794592
ko05031	Amphetamine addiction	3/946	91/7206	0.00259531316208
ko04810	Regulation of actin cytoskeleton	19/946	264/7206	0.00280658107339
ko04931	Insulin resistance	7/946	137/7206	0.00304110313944
ko05140	Leishmaniasis	2/946	75/7206	0.00312796582536
ko04923	Regulation of lipolysis in adipocytes	2/946	77/7206	0.00324286113586
ko04550	Signaling pathways regulating pluripotency of stem cells	35/946	165/7206	0.00333252576686
ko04622	RIG-I-like receptor signaling pathway	1/946	62/7206	0.00364632162682
ko05133	Pertussis	3/946	87/7206	0.00367665657879
ko05132	Salmonella infection	4/946	98/7206	0.00401256671439
ko00564	Glycerophospholipid metabolism	4/946	99/7206	0.00401528437671
ko04620	Toll-like receptor signaling pathway	4/946	100/7206	0.00407442394436
ko05152	Tuberculosis	12/946	187/7206	0.00412620594612
ko05231	Choline metabolism in cancer	7/946	134/7206	0.0041498674913
ko04120	Ubiquitin mediated proteolysis	30/946	138/7206	0.00469661761891
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/946	59/7206	0.00543941081353
ko04071	Sphingolipid signaling pathway	10/946	162/7206	0.00638875486423
ko05167	Kaposi's sarcoma-associated herpesvirus infection	13/946	191/7206	0.00644629641458
ko04014	Ras signaling pathway	22/946	279/7206	0.006534159489
ko03060	Protein export	8/946	23/7206	0.00680529985442
ko04142	Lysosome	9/946	151/7206	0.00688553771649
ko04670	Leukocyte transendothelial migration	9/946	151/7206	0.00688553771649
ko04712	Circadian rhythm - plant	4/946	7/7206	0.00743337282814
ko04976	Bile secretion	3/946	80/7206	0.0074385981352
ko05145	Toxoplasmosis	7/946	126/7206	0.00756391899801
ko04930	Type II diabetes mellitus	1/946	54/7206	0.00764577362
ko01200	Carbon metabolism	7/946	128/7206	0.00766821271099
ko04922	Glucagon signaling pathway	7/946	128/7206	0.00766821271099
ko04340	Hedgehog signaling pathway	15/946	58/7206	0.00927999454187
ko04950	Maturity onset diabetes of the young	9/946	29/7206	0.00961088804065
ko04068	FoxO signaling pathway	11/946	167/7206	0.0102041494098
ko05168	Herpes simplex infection	36/946	182/7206	0.010211421497
ko04660	T cell receptor signaling pathway	7/946	124/7206	0.0102343112834
ko04146	Peroxisome	4/946	89/7206	0.0109345813594
ko04390	Hippo signaling pathway	37/946	188/7206	0.0112951738
ko05202	Transcriptional misregulation in cancer	37/946	188/7206	0.0112951738
ko00380	Tryptophan metabolism	1/946	50/7206	0.0113428988599
ko00514	Other types of O-glycan biosynthesis	9/946	30/7206	0.0121695847129
ko00561	Glycerolipid metabolism	2/946	63/7206	0.0137323223329
ko00600	Sphingolipid metabolism	2/946	63/7206	0.0137323223329
ko04015	Rap1 signaling pathway	23/946	278/7206	0.0141018081436
ko04918	Thyroid hormone synthesis	4/946	86/7206	0.01519322951
ko05146	Amoebiasis	5/946	99/7206	0.0153167543539
ko04657	IL-17 signaling pathway	4/946	87/7206	0.015384083405
ko04910	Insulin signaling pathway	12/946	172/7206	0.0157016150032
ko04514	Cell adhesion molecules (CAMs)	8/946	130/7206	0.0173513561995
ko04114	Oocyte meiosis	28/946	139/7206	0.021390284132
ko04139	Mitophagy - yeast	10/946	37/7206	0.0233765269575
ko00071	Fatty acid degradation	1/946	45/7206	0.0248183340296
ko00620	Pyruvate metabolism	1/946	46/7206	0.0254329335683
ko05161	Hepatitis B	13/946	173/7206	0.0294612529434
ko04666	Fc gamma R-mediated phagocytosis	8/946	122/7206	0.0296141494632
ko04066	HIF-1 signaling pathway	8/946	123/7206	0.0299470225093
ko04917	Prolactin signaling pathway	5/946	87/7206	0.0374645831864
ko04350	TGF-beta signaling pathway	21/946	103/7206	0.038091939286
ko00670	One carbon pool by folate	6/946	20/7206	0.0383488726521
ko04914	Progesterone-mediated oocyte maturation	21/946	104/7206	0.0395723952216
ko04370	VEGF signaling pathway	4/946	77/7206	0.0399587158381
ko04664	Fc epsilon RI signaling pathway	4/946	77/7206	0.0399587158381
ko00280	Valine, leucine and isoleucine degradation	2/946	54/7206	0.0406334382226
ko05224	Breast cancer	32/946	174/7206	0.0409911668714
ko05211	Renal cell carcinoma	6/946	96/7206	0.0466929420201
ko04658	Th1 and Th2 cell differentiation	6/946	96/7206	0.0466929420201
ko04064	NF-kappa B signaling pathway	6/946	96/7206	0.0466929420201