ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 26/235 191/7206 4.15107709979e-10 ko04380 Osteoclast differentiation 20/235 134/7206 9.76237165929e-09 ko04660 T cell receptor signaling pathway 18/235 124/7206 8.57898802971e-08 ko04672 Intestinal immune network for IgA production 10/235 37/7206 1.80534510408e-07 ko05131 Shigellosis 13/235 82/7206 2.04629894611e-06 ko05323 Rheumatoid arthritis 13/235 89/7206 5.26519735067e-06 ko05152 Tuberculosis 19/235 187/7206 9.71093896095e-06 ko04064 NF-kappa B signaling pathway 13/235 96/7206 1.23412014939e-05 ko04621 NOD-like receptor signaling pathway 17/235 157/7206 1.25147273975e-05 ko04630 Jak-STAT signaling pathway 15/235 132/7206 2.30997806293e-05 ko05164 Influenza A 17/235 167/7206 2.82511387628e-05 ko04668 TNF signaling pathway 14/235 120/7206 3.22726096804e-05 ko05145 Toxoplasmosis 14/235 126/7206 5.58304500146e-05 ko04658 Th1 and Th2 cell differentiation 12/235 96/7206 6.02688466557e-05 ko04650 Natural killer cell mediated cytotoxicity 12/235 97/7206 6.68228837322e-05 ko05132 Salmonella infection 12/235 98/7206 7.3983339741e-05 ko04062 Chemokine signaling pathway 18/235 201/7206 9.06842510052e-05 ko05133 Pertussis 11/235 87/7206 0.00011028866825 ko05140 Leishmaniasis 10/235 75/7206 0.000144675176096 ko04622 RIG-I-like receptor signaling pathway 9/235 62/7206 0.000160651447906 ko04620 Toll-like receptor signaling pathway 11/235 100/7206 0.00038424433853 ko05321 Inflammatory bowel disease (IBD) 8/235 56/7206 0.000416734226186 ko05162 Measles 12/235 120/7206 0.000509768759732 ko04659 Th17 cell differentiation 11/235 106/7206 0.000635215194227 ko04217 Necroptosis 15/235 178/7206 0.000671587544085 ko05150 Staphylococcus aureus infection 6/235 36/7206 0.000966606305953 ko04670 Leukocyte transendothelial migration 13/235 151/7206 0.00125100407126 ko04933 AGE-RAGE signaling pathway in diabetic complications 12/235 135/7206 0.001453759108 ko05161 Hepatitis B 14/235 173/7206 0.00149549785285 ko05168 Herpes simplex infection 14/235 182/7206 0.00241173089774 ko05340 Primary immunodeficiency 5/235 30/7206 0.00258401600321 ko05144 Malaria 6/235 45/7206 0.00316598618124 ko05142 Chagas disease (American trypanosomiasis) 11/235 130/7206 0.00334839991796 ko04610 Complement and coagulation cascades 8/235 79/7206 0.00402637372129 ko05034 Alcoholism 1/235 238/7206 0.00495565209525 ko04917 Prolactin signaling pathway 8/235 87/7206 0.00722246756818 ko04210 Apoptosis 13/235 180/7206 0.00819874708352 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/235 92/7206 0.0100179554004 ko04623 Cytosolic DNA-sensing pathway 5/235 41/7206 0.0101666518837 ko05016 Huntington's disease 1/235 215/7206 0.0104489445123 ko04611 Platelet activation 12/235 163/7206 0.0110717204538 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/235 191/7206 0.0110721818363 ko00051 Fructose and mannose metabolism 5/235 42/7206 0.0112416462095 ko04664 Fc epsilon RI signaling pathway 7/235 77/7206 0.0124198996339 ko05166 HTLV-I infection 17/235 292/7206 0.0177098605197 ko04666 Fc gamma R-mediated phagocytosis 9/235 122/7206 0.0179011908556 ko04657 IL-17 signaling pathway 7/235 87/7206 0.0229957517458 ko04662 B cell receptor signaling pathway 7/235 88/7206 0.0243152183596 ko00120 Primary bile acid biosynthesis 3/235 20/7206 0.0259076641098 ko04728 Dopaminergic synapse 1/235 185/7206 0.0324108507133 ko00966 Glucosinolate biosynthesis 1/235 1/7206 0.0326117124619 ko05160 Hepatitis C 10/235 153/7206 0.0335571406285 ko05130 Pathogenic Escherichia coli infection 6/235 77/7206 0.0391200075728 ko05100 Bacterial invasion of epithelial cells 7/235 99/7206 0.0423709402776 ko00140 Steroid hormone biosynthesis 4/235 41/7206 0.0435100906065 ko04723 Retrograde endocannabinoid signaling 1/235 175/7206 0.047453927307