ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 12/107 152/7206 2.2194465059e-06 ko05032 Morphine addiction 10/107 110/7206 4.64020900857e-06 ko04024 cAMP signaling pathway 15/107 279/7206 1.37574339714e-05 ko04713 Circadian entrainment 10/107 136/7206 3.05111014575e-05 ko04727 GABAergic synapse 9/107 110/7206 3.33760812365e-05 ko04723 Retrograde endocannabinoid signaling 11/107 175/7206 5.19031055127e-05 ko04720 Long-term potentiation 8/107 99/7206 0.000101645523161 ko04072 Phospholipase D signaling pathway 11/107 197/7206 0.000150893258001 ko05033 Nicotine addiction 6/107 56/7206 0.000165502847672 ko04261 Adrenergic signaling in cardiomyocytes 11/107 205/7206 0.000214189732661 ko04921 Oxytocin signaling pathway 11/107 209/7206 0.000253486420337 ko05030 Cocaine addiction 6/107 73/7206 0.000707737149804 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6/107 79/7206 0.00107559394631 ko05414 Dilated cardiomyopathy 7/107 112/7206 0.00131863027692 ko04728 Dopaminergic synapse 9/107 185/7206 0.00164117440079 ko04020 Calcium signaling pathway 11/107 265/7206 0.00183003305077 ko04742 Taste transduction 5/107 61/7206 0.00202058510631 ko04915 Estrogen signaling pathway 7/107 131/7206 0.00322884722293 ko05231 Choline metabolism in cancer 7/107 134/7206 0.00366249175343 ko04080 Neuroactive ligand-receptor interaction 14/107 423/7206 0.00521453020423 ko00750 Vitamin B6 metabolism 2/107 9/7206 0.00734650255274 ko04911 Insulin secretion 6/107 117/7206 0.00769692863183 ko05031 Amphetamine addiction 5/107 91/7206 0.0111342927029 ko04260 Cardiac muscle contraction 5/107 98/7206 0.0149927466185 ko05410 Hypertrophic cardiomyopathy (HCM) 5/107 100/7206 0.0162410995171 ko04139 Mitophagy - yeast 3/107 37/7206 0.0171530035491 ko04144 Endocytosis 11/107 342/7206 0.0175706923207 ko00604 Glycosphingolipid biosynthesis - ganglio series 2/107 14/7206 0.017694332155 ko04925 Aldosterone synthesis and secretion 5/107 105/7206 0.0196606870741 ko04360 Axon guidance 8/107 233/7206 0.0221777140381 ko04972 Pancreatic secretion 5/107 111/7206 0.0243507045791 ko04151 PI3K-Akt signaling pathway 1/107 390/7206 0.0304487871655 ko04725 Cholinergic synapse 6/107 160/7206 0.0314015599235 ko04912 GnRH signaling pathway 5/107 122/7206 0.0347042189873 ko04750 Inflammatory mediator regulation of TRP channels 5/107 122/7206 0.0347042189873 ko04666 Fc gamma R-mediated phagocytosis 5/107 122/7206 0.0347042189873 ko04022 cGMP-PKG signaling pathway 7/107 216/7206 0.0412391359553 ko04011 MAPK signaling pathway - yeast 3/107 53/7206 0.0436571352932 ko04371 Apelin signaling pathway 6/107 177/7206 0.0476038937869