ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 51/497 191/7206 5.97097587291e-18 ko04380 Osteoclast differentiation 37/497 134/7206 8.36583425278e-14 ko05164 Influenza A 39/497 167/7206 5.91876885544e-12 ko05340 Primary immunodeficiency 16/497 30/7206 1.22286800465e-11 ko04621 NOD-like receptor signaling pathway 37/497 157/7206 1.5846623546e-11 ko04650 Natural killer cell mediated cytotoxicity 28/497 97/7206 3.01076963328e-11 ko05162 Measles 31/497 120/7206 6.10498964987e-11 ko05140 Leishmaniasis 23/497 75/7206 4.78621544481e-10 ko04064 NF-kappa B signaling pathway 26/497 96/7206 7.28396290739e-10 ko05321 Inflammatory bowel disease (IBD) 19/497 56/7206 2.36494122604e-09 ko05145 Toxoplasmosis 29/497 126/7206 4.78787382873e-09 ko05168 Herpes simplex infection 36/497 182/7206 5.32448907371e-09 ko04659 Th17 cell differentiation 26/497 106/7206 7.3301235432e-09 ko04217 Necroptosis 35/497 178/7206 1.02967189124e-08 ko05330 Allograft rejection 12/497 24/7206 1.28089123644e-08 ko05320 Autoimmune thyroid disease 13/497 29/7206 1.66984926458e-08 ko05150 Staphylococcus aureus infection 14/497 36/7206 4.25244003637e-08 ko04620 Toll-like receptor signaling pathway 24/497 100/7206 4.41439052773e-08 ko05332 Graft-versus-host disease 10/497 18/7206 5.89582882595e-08 ko04672 Intestinal immune network for IgA production 14/497 37/7206 6.41393294006e-08 ko05152 Tuberculosis 34/497 187/7206 1.27185691956e-07 ko04612 Antigen processing and presentation 20/497 77/7206 1.4783817912e-07 ko04640 Hematopoietic cell lineage 18/497 64/7206 1.68215220537e-07 ko00120 Primary bile acid biosynthesis 10/497 20/7206 2.19353836323e-07 ko04658 Th1 and Th2 cell differentiation 22/497 96/7206 3.86598235926e-07 ko04630 Jak-STAT signaling pathway 26/497 132/7206 8.16455685054e-07 ko04660 T cell receptor signaling pathway 25/497 124/7206 8.43930531386e-07 ko04610 Complement and coagulation cascades 19/497 79/7206 1.1024592317e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 31/497 191/7206 6.67551133915e-06 ko04662 B cell receptor signaling pathway 18/497 88/7206 2.38319903521e-05 ko05144 Malaria 12/497 45/7206 3.56775042525e-05 ko04940 Type I diabetes mellitus 10/497 32/7206 3.59513315655e-05 ko04062 Chemokine signaling pathway 30/497 201/7206 5.05342329342e-05 ko04622 RIG-I-like receptor signaling pathway 14/497 62/7206 6.13128716184e-05 ko05310 Asthma 7/497 17/7206 7.53010814718e-05 ko05323 Rheumatoid arthritis 17/497 89/7206 9.92901164273e-05 ko00590 Arachidonic acid metabolism 12/497 52/7206 0.000164200670192 ko05142 Chagas disease (American trypanosomiasis) 21/497 130/7206 0.000282532033378 ko04310 Wnt signaling pathway 2/497 181/7206 0.000481429054719 ko03040 Spliceosome 1/497 145/7206 0.000692149396571 ko05133 Pertussis 15/497 87/7206 0.000791665645546 ko05160 Hepatitis C 22/497 153/7206 0.000949629622575 ko04137 Mitophagy - animal 14/497 82/7206 0.00129498290266 ko04668 TNF signaling pathway 18/497 120/7206 0.00153491681302 ko00140 Steroid hormone biosynthesis 9/497 41/7206 0.00157166799028 ko04623 Cytosolic DNA-sensing pathway 9/497 41/7206 0.00157166799028 ko05161 Hepatitis B 23/497 173/7206 0.00206878235665 ko03010 Ribosome 1/497 129/7206 0.00224078780731 ko04145 Phagosome 22/497 162/7206 0.00233909851217 ko04611 Platelet activation 22/497 163/7206 0.0024312151113 ko03050 Proteasome 10/497 54/7206 0.00337968186045 ko05034 Alcoholism 6/497 238/7206 0.00391205163356 ko04916 Melanogenesis 2/497 142/7206 0.00409757573341 ko04911 Insulin secretion 1/497 117/7206 0.00473312853137 ko04390 Hippo signaling pathway 4/497 188/7206 0.00514299021349 ko04664 Fc epsilon RI signaling pathway 12/497 77/7206 0.0060589916302 ko05032 Morphine addiction 1/497 110/7206 0.00675292541278 ko00051 Fructose and mannose metabolism 8/497 42/7206 0.0070936032533 ko03320 PPAR signaling pathway 11/497 69/7206 0.00710138768748 ko04530 Tight junction 6/497 228/7206 0.00727674236669 ko00592 alpha-Linolenic acid metabolism 5/497 19/7206 0.00791172607983 ko04670 Leukocyte transendothelial migration 19/497 151/7206 0.00899352669794 ko04146 Peroxisome 13/497 89/7206 0.00927399634686 ko05418 Fluid shear stress and atherosclerosis 21/497 173/7206 0.00946910612614 ko05206 MicroRNAs in cancer 4/497 177/7206 0.00984789856775 ko04210 Apoptosis 22/497 180/7206 0.0102224615712 ko00982 Drug metabolism - cytochrome P450 7/497 37/7206 0.0119682119963 ko05416 Viral myocarditis 9/497 55/7206 0.0120969716946 ko04514 Cell adhesion molecules (CAMs) 17/497 130/7206 0.0126634321418 ko05204 Chemical carcinogenesis 8/497 48/7206 0.0157956238435 ko04728 Dopaminergic synapse 5/497 185/7206 0.018005628196 ko00980 Metabolism of xenobiotics by cytochrome P450 7/497 40/7206 0.0181407801528 ko04110 Cell cycle 3/497 145/7206 0.0186510292089 ko04111 Cell cycle - yeast 1/497 90/7206 0.0203357044244 ko01212 Fatty acid metabolism 9/497 60/7206 0.020760386142 ko05010 Alzheimer's disease 6/497 202/7206 0.0231793348762 ko05132 Salmonella infection 13/497 98/7206 0.023804470963 ko05169 Epstein-Barr virus infection 23/497 206/7206 0.0241154612743 ko04713 Circadian entrainment 3/497 136/7206 0.0250171104781 ko01040 Biosynthesis of unsaturated fatty acids 5/497 25/7206 0.0257027557608 ko00950 Isoquinoline alkaloid biosynthesis 3/497 10/7206 0.0271616227051 ko04666 Fc gamma R-mediated phagocytosis 15/497 122/7206 0.0280332260776 ko05016 Huntington's disease 7/497 215/7206 0.0283933685932 ko03018 RNA degradation 1/497 84/7206 0.0294403237875 ko00511 Other glycan degradation 5/497 26/7206 0.0300766991359 ko04723 Retrograde endocannabinoid signaling 5/497 175/7206 0.0328541091426 ko04012 ErbB signaling pathway 2/497 109/7206 0.0337267862441 ko04724 Glutamatergic synapse 4/497 152/7206 0.0340067387608 ko04540 Gap junction 3/497 128/7206 0.0343151278634 ko04360 Axon guidance 8/497 233/7206 0.0343185236659 ko04972 Pancreatic secretion 2/497 111/7206 0.0346577992664 ko01524 Platinum drug resistance 10/497 76/7206 0.0391928375504 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/497 5/7206 0.041284533413 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 1/497 79/7206 0.042637778746 ko04721 Synaptic vesicle cycle 1/497 80/7206 0.0429365557612 ko04740 Olfactory transduction 1/497 80/7206 0.0429365557612 ko05146 Amoebiasis 12/497 99/7206 0.0456992485115 ko04925 Aldosterone synthesis and secretion 2/497 105/7206 0.0485296452753 ko00190 Oxidative phosphorylation 3/497 127/7206 0.0487890370567