ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	209/1197	423/7206	4.04037524826e-59
ko04724	Glutamatergic synapse	92/1197	152/7206	5.13361712829e-35
ko05033	Nicotine addiction	50/1197	56/7206	5.11908652073e-33
ko04713	Circadian entrainment	80/1197	136/7206	2.53044231357e-29
ko04727	GABAergic synapse	70/1197	110/7206	8.80545067884e-29
ko05032	Morphine addiction	70/1197	110/7206	8.80545067884e-29
ko04728	Dopaminergic synapse	91/1197	185/7206	2.35656984433e-25
ko04725	Cholinergic synapse	78/1197	160/7206	1.49931347209e-21
ko04721	Synaptic vesicle cycle	50/1197	80/7206	2.30040926347e-20
ko04723	Retrograde endocannabinoid signaling	80/1197	175/7206	7.1645222917e-20
ko04024	cAMP signaling pathway	107/1197	279/7206	5.55798517101e-19
ko04744	Phototransduction	30/1197	36/7206	2.10146612086e-18
ko04020	Calcium signaling pathway	101/1197	265/7206	9.47569476362e-18
ko04911	Insulin secretion	59/1197	117/7206	1.82660514797e-17
ko04726	Serotonergic synapse	65/1197	137/7206	2.2588907004e-17
ko04740	Olfactory transduction	44/1197	80/7206	3.86613562751e-15
ko04921	Oxytocin signaling pathway	81/1197	209/7206	6.8927105932e-15
ko04742	Taste transduction	37/1197	61/7206	8.67144418302e-15
ko05031	Amphetamine addiction	46/1197	91/7206	6.08636488738e-14
ko04720	Long-term potentiation	48/1197	99/7206	1.33009138092e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1197	205/7206	6.62250994378e-12
ko04970	Salivary secretion	44/1197	95/7206	1.02211237775e-11
ko04925	Aldosterone synthesis and secretion	46/1197	105/7206	3.80659784729e-11
ko03040	Spliceosome	1/1197	145/7206	1.19720250041e-10
ko05030	Cocaine addiction	33/1197	73/7206	8.66562372363e-09
ko04971	Gastric acid secretion	40/1197	98/7206	8.92796576482e-09
ko05168	Herpes simplex infection	6/1197	182/7206	2.39890460089e-08
ko05322	Systemic lupus erythematosus	4/1197	151/7206	5.6682600184e-08
ko05203	Viral carcinogenesis	18/1197	277/7206	5.75759246536e-07
ko03013	RNA transport	7/1197	166/7206	1.28788798123e-06
ko04022	cGMP-PKG signaling pathway	64/1197	216/7206	1.54120579658e-06
ko04972	Pancreatic secretion	39/1197	111/7206	1.85341825032e-06
ko04745	Phototransduction - fly	19/1197	38/7206	1.96056659737e-06
ko04060	Cytokine-cytokine receptor interaction	10/1197	191/7206	2.55143898947e-06
ko04750	Inflammatory mediator regulation of TRP channels	41/1197	122/7206	3.45075125538e-06
ko04141	Protein processing in endoplasmic reticulum	10/1197	184/7206	5.00315195242e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1197	74/7206	1.01454914506e-05
ko04010	MAPK signaling pathway	84/1197	321/7206	1.03632330346e-05
ko04924	Renin secretion	31/1197	86/7206	1.21759729125e-05
ko04120	Ubiquitin mediated proteolysis	6/1197	138/7206	1.38386243727e-05
ko04966	Collecting duct acid secretion	14/1197	26/7206	1.50675943336e-05
ko04621	NOD-like receptor signaling pathway	8/1197	157/7206	1.74812879766e-05
ko04540	Gap junction	41/1197	128/7206	1.8373230789e-05
ko04360	Axon guidance	64/1197	233/7206	2.18426941068e-05
ko04514	Cell adhesion molecules (CAMs)	41/1197	130/7206	2.2392166916e-05
ko04110	Cell cycle	7/1197	145/7206	2.25538898722e-05
ko05162	Measles	5/1197	120/7206	3.53819961342e-05
ko05169	Epstein-Barr virus infection	14/1197	206/7206	3.69270037872e-05
ko04730	Long-term depression	28/1197	78/7206	3.84682403362e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1197	79/7206	4.52709364137e-05
ko04070	Phosphatidylinositol signaling system	36/1197	112/7206	5.0442355208e-05
ko05164	Influenza A	10/1197	167/7206	5.23013482754e-05
ko04976	Bile secretion	28/1197	80/7206	5.46389197854e-05
ko04915	Estrogen signaling pathway	40/1197	131/7206	7.00105660519e-05
ko04260	Cardiac muscle contraction	32/1197	98/7206	9.05972045155e-05
ko05110	Vibrio cholerae infection	23/1197	63/7206	0.000115412789083
ko04612	Antigen processing and presentation	2/1197	77/7206	0.000166721482703
ko03008	Ribosome biogenesis in eukaryotes	2/1197	79/7206	0.000178457153136
ko04626	Plant-pathogen interaction	10/1197	18/7206	0.000186196190939
ko04072	Phospholipase D signaling pathway	53/1197	197/7206	0.000203262910643
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1197	59/7206	0.000333751968242
ko04014	Ras signaling pathway	69/1197	279/7206	0.000393310717474
ko05414	Dilated cardiomyopathy	33/1197	112/7206	0.000729497052706
ko04912	GnRH signaling pathway	35/1197	122/7206	0.000792377704184
ko05205	Proteoglycans in cancer	26/1197	271/7206	0.00111006728541
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1197	182/7206	0.00119235399264
ko04064	NF-kappa B signaling pathway	5/1197	96/7206	0.001278389889
ko05140	Leishmaniasis	3/1197	75/7206	0.00149667694213
ko04330	Notch signaling pathway	2/1197	62/7206	0.00176856082585
ko04214	Apoptosis - fly	3/1197	72/7206	0.00214324432565
ko00310	Lysine degradation	3/1197	73/7206	0.00221144324486
ko05166	HTLV-I infection	30/1197	292/7206	0.00221668670481
ko04371	Apelin signaling pathway	45/1197	177/7206	0.00281284442608
ko04918	Thyroid hormone synthesis	25/1197	86/7206	0.00330029445468
ko04658	Th1 and Th2 cell differentiation	6/1197	96/7206	0.00354243693997
ko00071	Fatty acid degradation	1/1197	45/7206	0.00435533396199
ko03420	Nucleotide excision repair	1/1197	46/7206	0.00442563733313
ko04964	Proximal tubule bicarbonate reclamation	11/1197	29/7206	0.00480186925342
ko03018	RNA degradation	5/1197	84/7206	0.00492702850379
ko05016	Huntington's disease	21/1197	215/7206	0.00507484897521
ko00520	Amino sugar and nucleotide sugar metabolism	2/1197	55/7206	0.00563269203492
ko04973	Carbohydrate digestion and absorption	14/1197	42/7206	0.00649369079533
ko05131	Shigellosis	5/1197	82/7206	0.00684709460778
ko04115	p53 signaling pathway	4/1197	74/7206	0.00684832895981
ko04923	Regulation of lipolysis in adipocytes	22/1197	77/7206	0.00809121310604
ko00590	Arachidonic acid metabolism	2/1197	52/7206	0.00820488617279
ko04916	Melanogenesis	36/1197	142/7206	0.00831360419628
ko00330	Arginine and proline metabolism	3/1197	61/7206	0.00912469736248
ko04622	RIG-I-like receptor signaling pathway	3/1197	62/7206	0.00920360338108
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1197	100/7206	0.00936790507784
ko04610	Complement and coagulation cascades	5/1197	79/7206	0.00951698915988
ko04657	IL-17 signaling pathway	6/1197	87/7206	0.0128503900546
ko05161	Hepatitis B	17/1197	173/7206	0.0129331100271
ko04015	Rap1 signaling pathway	62/1197	278/7206	0.0133764024439
ko00240	Pyrimidine metabolism	9/1197	110/7206	0.0138425905289
ko03410	Base excision repair	1/1197	38/7206	0.014756688747
ko05145	Toxoplasmosis	11/1197	126/7206	0.015169441095
ko04350	TGF-beta signaling pathway	8/1197	103/7206	0.0154467205789
ko04922	Glucagon signaling pathway	32/1197	128/7206	0.0157960158257
ko00290	Valine, leucine and isoleucine biosynthesis	3/1197	4/7206	0.0160212030267
ko04978	Mineral absorption	13/1197	40/7206	0.0162612352843
ko04630	Jak-STAT signaling pathway	12/1197	132/7206	0.0177429931751
ko05231	Choline metabolism in cancer	33/1197	134/7206	0.0183373304034
ko05321	Inflammatory bowel disease (IBD)	3/1197	56/7206	0.0185046370001
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1197	14/7206	0.0186754703149
ko05034	Alcoholism	53/1197	238/7206	0.0210085216616
ko04146	Peroxisome	7/1197	89/7206	0.0217709531515
ko05222	Small cell lung cancer	7/1197	89/7206	0.0217709531515
ko05214	Glioma	21/1197	79/7206	0.0220127426769
ko05144	Malaria	2/1197	45/7206	0.0253688772482
ko04210	Apoptosis	19/1197	180/7206	0.0254803474959
ko00280	Valine, leucine and isoleucine degradation	3/1197	54/7206	0.0263095704731
ko04640	Hematopoietic cell lineage	4/1197	64/7206	0.0265023321585
ko00480	Glutathione metabolism	3/1197	55/7206	0.0269346725383
ko05416	Viral myocarditis	3/1197	55/7206	0.0269346725383
ko00910	Nitrogen metabolism	7/1197	19/7206	0.0274338074128
ko05215	Prostate cancer	10/1197	111/7206	0.0284821389973
ko05418	Fluid shear stress and atherosclerosis	18/1197	173/7206	0.0292044659753
ko00562	Inositol phosphate metabolism	23/1197	89/7206	0.0301012814527
ko04217	Necroptosis	19/1197	178/7206	0.0317705948803
ko04140	Autophagy - animal	17/1197	164/7206	0.0330258314309
ko00860	Porphyrin and chlorophyll metabolism	1/1197	34/7206	0.0339412356679
ko03320	PPAR signaling pathway	5/1197	69/7206	0.0339602129888
ko04113	Meiosis - yeast	5/1197	70/7206	0.0343429367275
ko04510	Focal adhesion	28/1197	240/7206	0.0343747961362
ko04960	Aldosterone-regulated sodium reabsorption	12/1197	41/7206	0.0356480267954
ko04016	MAPK signaling pathway - plant	7/1197	20/7206	0.0363231857759
ko04930	Type II diabetes mellitus	15/1197	54/7206	0.0407966039623
ko04620	Toll-like receptor signaling pathway	9/1197	100/7206	0.0414855089526
ko05217	Basal cell carcinoma	5/1197	68/7206	0.0473028947409
ko04659	Th17 cell differentiation	10/1197	106/7206	0.0478567124735
ko04270	Vascular smooth muscle contraction	35/1197	154/7206	0.0480493418546
ko05340	Primary immunodeficiency	1/1197	30/7206	0.0488011239818
ko04136	Autophagy - other	1/1197	31/7206	0.049555387415