ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 60/216 423/7206 1.04075870407e-25 ko04724 Glutamatergic synapse 38/216 152/7206 2.68465994502e-25 ko05033 Nicotine addiction 19/216 56/7206 8.28396401225e-16 ko04728 Dopaminergic synapse 27/216 185/7206 4.88833587946e-12 ko05014 Amyotrophic lateral sclerosis (ALS) 17/216 74/7206 3.44007743997e-11 ko04727 GABAergic synapse 19/216 110/7206 4.50726720218e-10 ko04723 Retrograde endocannabinoid signaling 23/216 175/7206 1.74275479965e-09 ko04713 Circadian entrainment 19/216 136/7206 1.77379398784e-08 ko04742 Taste transduction 13/216 61/7206 2.0257510791e-08 ko04024 cAMP signaling pathway 27/216 279/7206 5.4755063719e-08 ko04726 Serotonergic synapse 18/216 137/7206 1.12613563036e-07 ko05032 Morphine addiction 15/216 110/7206 8.23702482548e-07 ko04720 Long-term potentiation 14/216 99/7206 1.2373834516e-06 ko05030 Cocaine addiction 12/216 73/7206 1.42137670642e-06 ko05031 Amphetamine addiction 13/216 91/7206 2.67013250955e-06 ko04020 Calcium signaling pathway 23/216 265/7206 3.80910110889e-06 ko04725 Cholinergic synapse 15/216 160/7206 8.31916516766e-05 ko04721 Synaptic vesicle cycle 10/216 80/7206 0.000124948220275 ko04010 MAPK signaling pathway 22/216 321/7206 0.000275311586781 ko04730 Long-term depression 9/216 78/7206 0.000500417617715 ko04261 Adrenergic signaling in cardiomyocytes 15/216 205/7206 0.00121012587278 ko04921 Oxytocin signaling pathway 15/216 209/7206 0.0014696826428 ko04514 Cell adhesion molecules (CAMs) 11/216 130/7206 0.0017318463628 ko04915 Estrogen signaling pathway 11/216 131/7206 0.00184189083207 ko00430 Taurine and hypotaurine metabolism 3/216 14/7206 0.00757068148679 ko04072 Phospholipase D signaling pathway 13/216 197/7206 0.00842298700793 ko02024 Quorum sensing 3/216 15/7206 0.00925680416695 ko05010 Alzheimer's disease 13/216 202/7206 0.00948747944697 ko05203 Viral carcinogenesis 2/216 277/7206 0.0179328443004 ko04972 Pancreatic secretion 8/216 111/7206 0.0180179717617 ko05034 Alcoholism 13/216 238/7206 0.0318040145075 ko00515 Mannose type O-glycan biosynthesis 3/216 25/7206 0.037597679556 ko00650 Butanoate metabolism 3/216 26/7206 0.0415900053949 ko04060 Cytokine-cytokine receptor interaction 1/216 191/7206 0.0477621425407 ko04014 Ras signaling pathway 14/216 279/7206 0.0490496510395