ko pathway ratio_in_study ratio_in_pop p_value ko04727 GABAergic synapse 19/254 110/7206 6.94162724131e-09 ko05032 Morphine addiction 17/254 110/7206 2.39704607299e-07 ko05033 Nicotine addiction 12/254 56/7206 3.98297884327e-07 ko04724 Glutamatergic synapse 19/254 152/7206 1.37708847556e-06 ko04728 Dopaminergic synapse 21/254 185/7206 1.87820589471e-06 ko04723 Retrograde endocannabinoid signaling 20/254 175/7206 2.99807466827e-06 ko04740 Olfactory transduction 13/254 80/7206 3.65042003067e-06 ko04080 Neuroactive ligand-receptor interaction 32/254 423/7206 3.28842026377e-05 ko04726 Serotonergic synapse 15/254 137/7206 8.79250219979e-05 ko04974 Protein digestion and absorption 12/254 96/7206 0.000127130024681 ko04260 Cardiac muscle contraction 12/254 98/7206 0.000155300869733 ko05014 Amyotrophic lateral sclerosis (ALS) 10/254 74/7206 0.000243764810989 ko04713 Circadian entrainment 14/254 136/7206 0.000290506933783 ko04512 ECM-receptor interaction 10/254 79/7206 0.00041882301346 ko04721 Synaptic vesicle cycle 10/254 80/7206 0.000464093104291 ko04261 Adrenergic signaling in cardiomyocytes 17/254 205/7206 0.000872262670138 ko04744 Phototransduction 6/254 36/7206 0.00144598035339 ko04151 PI3K-Akt signaling pathway 26/254 390/7206 0.00160577738301 ko04725 Cholinergic synapse 13/254 160/7206 0.00414428032716 ko04742 Taste transduction 7/254 61/7206 0.00534640102833 ko00350 Tyrosine metabolism 5/254 33/7206 0.00552974352388 ko05152 Tuberculosis 1/254 187/7206 0.0150964575694 ko04060 Cytokine-cytokine receptor interaction 1/254 191/7206 0.015253318652 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/254 59/7206 0.0170811246044 ko04964 Proximal tubule bicarbonate reclamation 4/254 29/7206 0.0178957667104 ko04730 Long-term depression 7/254 78/7206 0.0195801820153 ko04217 Necroptosis 1/254 178/7206 0.0218807189613 ko04514 Cell adhesion molecules (CAMs) 10/254 130/7206 0.0252299181603 ko04510 Focal adhesion 15/254 240/7206 0.0301489542878 ko03013 RNA transport 1/254 166/7206 0.0314730238776 ko04068 FoxO signaling pathway 1/254 167/7206 0.0315643826059 ko05161 Hepatitis B 1/254 173/7206 0.0328967266002 ko04916 Melanogenesis 10/254 142/7206 0.0338961935175 ko05166 HTLV-I infection 4/254 292/7206 0.0351796251976 ko05030 Cocaine addiction 6/254 73/7206 0.0431159229047 ko04670 Leukocyte transendothelial migration 10/254 151/7206 0.044527473565