ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1178	423/7206	8.11860666795e-51
ko04724	Glutamatergic synapse	86/1178	152/7206	2.90202616625e-30
ko05033	Nicotine addiction	45/1178	56/7206	4.62152535603e-26
ko05032	Morphine addiction	66/1178	110/7206	1.82996205237e-25
ko04713	Circadian entrainment	74/1178	136/7206	1.02226446866e-24
ko04727	GABAergic synapse	63/1178	110/7206	8.13660463198e-23
ko04728	Dopaminergic synapse	84/1178	185/7206	4.78146264272e-21
ko04725	Cholinergic synapse	76/1178	160/7206	1.35419893333e-20
ko04020	Calcium signaling pathway	105/1178	265/7206	1.9207566513e-20
ko04024	cAMP signaling pathway	105/1178	279/7206	1.7605606879e-18
ko04911	Insulin secretion	58/1178	117/7206	4.4608802813e-17
ko04721	Synaptic vesicle cycle	46/1178	80/7206	4.51180898505e-17
ko04723	Retrograde endocannabinoid signaling	73/1178	175/7206	6.06402445281e-16
ko04921	Oxytocin signaling pathway	82/1178	209/7206	7.2097757641e-16
ko04726	Serotonergic synapse	62/1178	137/7206	9.78942221232e-16
ko05031	Amphetamine addiction	44/1178	91/7206	8.98252243757e-13
ko04970	Salivary secretion	45/1178	95/7206	1.24039598896e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1178	205/7206	3.37424843986e-11
ko04742	Taste transduction	32/1178	61/7206	7.88177189038e-11
ko04720	Long-term potentiation	43/1178	99/7206	1.37453468081e-10
ko04022	cGMP-PKG signaling pathway	72/1178	216/7206	4.75912211707e-10
ko04925	Aldosterone synthesis and secretion	43/1178	105/7206	1.31027167075e-09
ko03040	Spliceosome	2/1178	145/7206	4.13012351655e-09
ko03010	Ribosome	1/1178	129/7206	4.13689881497e-09
ko04971	Gastric acid secretion	39/1178	98/7206	2.00622188222e-08
ko04744	Phototransduction	20/1178	36/7206	8.299274647e-08
ko05322	Systemic lupus erythematosus	4/1178	151/7206	8.77074057263e-08
ko04070	Phosphatidylinositol signaling system	41/1178	112/7206	1.80634886039e-07
ko04360	Axon guidance	68/1178	233/7206	5.43196040646e-07
ko05030	Cocaine addiction	29/1178	73/7206	1.37481930524e-06
ko03013	RNA transport	7/1178	166/7206	1.91381761581e-06
ko04924	Renin secretion	32/1178	86/7206	2.37206731624e-06
ko04730	Long-term depression	30/1178	78/7206	2.85420756768e-06
ko04010	MAPK signaling pathway	85/1178	321/7206	2.91700958476e-06
ko04972	Pancreatic secretion	38/1178	111/7206	3.27925024888e-06
ko05168	Herpes simplex infection	9/1178	182/7206	3.43615502758e-06
ko04740	Olfactory transduction	30/1178	80/7206	4.31951027023e-06
ko04540	Gap junction	42/1178	128/7206	4.80676461463e-06
ko05203	Viral carcinogenesis	20/1178	277/7206	6.46117450633e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1178	79/7206	9.52305943921e-06
ko04966	Collecting duct acid secretion	14/1178	26/7206	1.24514506412e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1178	122/7206	1.78012974661e-05
ko04514	Cell adhesion molecules (CAMs)	41/1178	130/7206	1.88415197245e-05
ko04120	Ubiquitin mediated proteolysis	6/1178	138/7206	2.05931810308e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1178	74/7206	2.20675233554e-05
ko05414	Dilated cardiomyopathy	36/1178	112/7206	2.80958950172e-05
ko04072	Phospholipase D signaling pathway	55/1178	197/7206	3.32485901679e-05
ko04745	Phototransduction - fly	17/1178	38/7206	3.50266111832e-05
ko04014	Ras signaling pathway	72/1178	279/7206	4.50375163445e-05
ko05164	Influenza A	10/1178	167/7206	7.42160287548e-05
ko04110	Cell cycle	8/1178	145/7206	9.79001130122e-05
ko04060	Cytokine-cytokine receptor interaction	13/1178	191/7206	9.79621163898e-05
ko04923	Regulation of lipolysis in adipocytes	26/1178	77/7206	0.000146574492523
ko03008	Ribosome biogenesis in eukaryotes	2/1178	79/7206	0.000171733224882
ko04710	Circadian rhythm	17/1178	43/7206	0.000226651576836
ko04141	Protein processing in endoplasmic reticulum	13/1178	184/7206	0.000244565078148
ko05110	Vibrio cholerae infection	22/1178	63/7206	0.000411413783703
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1178	100/7206	0.000559408048205
ko04930	Type II diabetes mellitus	19/1178	54/7206	0.000635955553609
ko04621	NOD-like receptor signaling pathway	11/1178	157/7206	0.00065742801734
ko04260	Cardiac muscle contraction	29/1178	98/7206	0.000856856013885
ko04610	Complement and coagulation cascades	3/1178	79/7206	0.00105748893386
ko04976	Bile secretion	25/1178	80/7206	0.00111381409845
ko04915	Estrogen signaling pathway	36/1178	131/7206	0.00114236470904
ko04964	Proximal tubule bicarbonate reclamation	12/1178	29/7206	0.00117615416773
ko04270	Vascular smooth muscle contraction	41/1178	154/7206	0.00125147091072
ko04922	Glucagon signaling pathway	35/1178	128/7206	0.00152757707782
ko04612	Antigen processing and presentation	3/1178	77/7206	0.00157292370871
ko04371	Apelin signaling pathway	45/1178	177/7206	0.00186440444843
ko05169	Epstein-Barr virus infection	19/1178	206/7206	0.00395836144881
ko05231	Choline metabolism in cancer	35/1178	134/7206	0.00428074795257
ko03420	Nucleotide excision repair	1/1178	46/7206	0.0044159938286
ko04626	Plant-pathogen interaction	8/1178	18/7206	0.00467054682065
ko04960	Aldosterone-regulated sodium reabsorption	14/1178	41/7206	0.00471381548445
ko04973	Carbohydrate digestion and absorption	14/1178	42/7206	0.00574160282123
ko05162	Measles	9/1178	120/7206	0.00590253509048
ko03022	Basal transcription factors	1/1178	44/7206	0.00669107570794
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1178	59/7206	0.00684852353229
ko05140	Leishmaniasis	4/1178	75/7206	0.00690197001227
ko05144	Malaria	1/1178	45/7206	0.00699631770677
ko05214	Glioma	22/1178	79/7206	0.00873966457449
ko05161	Hepatitis B	16/1178	173/7206	0.00899901226324
ko04622	RIG-I-like receptor signaling pathway	3/1178	62/7206	0.00922737237583
ko05166	HTLV-I infection	32/1178	292/7206	0.0096234692829
ko05133	Pertussis	6/1178	87/7206	0.0128031351573
ko04015	Rap1 signaling pathway	61/1178	278/7206	0.012879294763
ko03410	Base excision repair	1/1178	38/7206	0.0148682234414
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1178	14/7206	0.0173126319107
ko03018	RNA degradation	6/1178	84/7206	0.0174429864697
ko05219	Bladder cancer	2/1178	48/7206	0.0175997959096
ko04912	GnRH signaling pathway	30/1178	122/7206	0.0182818944354
ko00562	Inositol phosphate metabolism	23/1178	89/7206	0.0202692438864
ko04217	Necroptosis	18/1178	178/7206	0.0233948682714
ko05131	Shigellosis	6/1178	82/7206	0.0236300491021
ko05205	Proteoglycans in cancer	31/1178	271/7206	0.023815486892
ko00310	Lysine degradation	5/1178	73/7206	0.0251150527153
ko00071	Fatty acid degradation	2/1178	45/7206	0.0254228461181
ko04115	p53 signaling pathway	5/1178	74/7206	0.0254854746095
ko00280	Valine, leucine and isoleucine degradation	3/1178	54/7206	0.0264440638994
ko00480	Glutathione metabolism	3/1178	55/7206	0.026587275815
ko04213	Longevity regulating pathway - multiple species	22/1178	86/7206	0.0267750735648
ko04918	Thyroid hormone synthesis	22/1178	86/7206	0.0267750735648
ko05321	Inflammatory bowel disease (IBD)	3/1178	56/7206	0.0272739986265
ko04916	Melanogenesis	33/1178	142/7206	0.0292424045146
ko04146	Peroxisome	7/1178	89/7206	0.0294853230543
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1178	182/7206	0.0323092050123
ko04214	Apoptosis - fly	5/1178	72/7206	0.0353598817146
ko04658	Th1 and Th2 cell differentiation	8/1178	96/7206	0.0358401798804
ko04064	NF-kappa B signaling pathway	8/1178	96/7206	0.0358401798804
ko00330	Arginine and proline metabolism	4/1178	61/7206	0.036174248943
ko00240	Pyrimidine metabolism	10/1178	110/7206	0.037247969958
ko00590	Arachidonic acid metabolism	3/1178	52/7206	0.0372916662227
ko05145	Toxoplasmosis	12/1178	126/7206	0.0380918744328
ko05016	Huntington's disease	24/1178	215/7206	0.038944103272
ko04657	IL-17 signaling pathway	7/1178	87/7206	0.0396232259411
ko04630	Jak-STAT signaling pathway	13/1178	132/7206	0.0428771752686
ko05217	Basal cell carcinoma	5/1178	68/7206	0.0466685250687
ko04711	Circadian rhythm - fly	5/1178	13/7206	0.0473973636709
ko05340	Primary immunodeficiency	1/1178	30/7206	0.0493069898668