ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1173	423/7206	2.01947115345e-50
ko04724	Glutamatergic synapse	90/1173	152/7206	6.35601250891e-34
ko05033	Nicotine addiction	48/1173	56/7206	2.36136375067e-30
ko05032	Morphine addiction	69/1173	110/7206	2.2262097177e-28
ko04727	GABAergic synapse	66/1173	110/7206	1.42102871275e-25
ko04713	Circadian entrainment	74/1173	136/7206	7.77066221354e-25
ko04721	Synaptic vesicle cycle	52/1173	80/7206	1.0405090646e-22
ko04728	Dopaminergic synapse	85/1173	185/7206	7.77400670501e-22
ko04725	Cholinergic synapse	76/1173	160/7206	1.03868534937e-20
ko04024	cAMP signaling pathway	107/1173	279/7206	1.0809883972e-19
ko04723	Retrograde endocannabinoid signaling	78/1173	175/7206	3.94341575843e-19
ko04020	Calcium signaling pathway	102/1173	265/7206	6.52217250672e-19
ko04742	Taste transduction	38/1173	61/7206	5.25793079644e-16
ko04911	Insulin secretion	55/1173	117/7206	4.64944041361e-15
ko04921	Oxytocin signaling pathway	78/1173	209/7206	1.07644406986e-13
ko04744	Phototransduction	26/1173	36/7206	1.20297771913e-13
ko04726	Serotonergic synapse	58/1173	137/7206	2.50344421024e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1173	205/7206	3.24301028666e-12
ko05031	Amphetamine addiction	41/1173	91/7206	7.99310836667e-11
ko04720	Long-term potentiation	43/1173	99/7206	1.19350263575e-10
ko03040	Spliceosome	1/1173	145/7206	3.28750544378e-10
ko04970	Salivary secretion	41/1173	95/7206	4.11659158191e-10
ko05203	Viral carcinogenesis	15/1173	277/7206	2.88787834593e-08
ko04925	Aldosterone synthesis and secretion	40/1173	105/7206	5.64153178252e-08
ko04022	cGMP-PKG signaling pathway	66/1173	216/7206	1.02408096031e-07
ko04360	Axon guidance	70/1173	233/7206	1.02813994934e-07
ko04971	Gastric acid secretion	37/1173	98/7206	2.30126510554e-07
ko04060	Cytokine-cytokine receptor interaction	8/1173	191/7206	2.4797990231e-07
ko04740	Olfactory transduction	32/1173	80/7206	2.95580758229e-07
ko05030	Cocaine addiction	30/1173	73/7206	3.44885613047e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1173	74/7206	1.74944704758e-06
ko04966	Collecting duct acid secretion	15/1173	26/7206	1.7785152505e-06
ko03013	RNA transport	7/1173	166/7206	1.8914436864e-06
ko05322	Systemic lupus erythematosus	6/1173	151/7206	3.30994893742e-06
ko05168	Herpes simplex infection	9/1173	182/7206	3.41238968063e-06
ko04514	Cell adhesion molecules (CAMs)	42/1173	130/7206	5.60394910519e-06
ko04010	MAPK signaling pathway	83/1173	321/7206	8.71726166498e-06
ko04972	Pancreatic secretion	37/1173	111/7206	1.13070396671e-05
ko04610	Complement and coagulation cascades	1/1173	79/7206	2.03261236257e-05
ko05414	Dilated cardiomyopathy	36/1173	112/7206	2.6170649728e-05
ko04070	Phosphatidylinositol signaling system	36/1173	112/7206	2.6170649728e-05
ko05164	Influenza A	9/1173	167/7206	2.71701640047e-05
ko04141	Protein processing in endoplasmic reticulum	11/1173	184/7206	2.83852464331e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1173	79/7206	3.69149708838e-05
ko04540	Gap junction	39/1173	128/7206	5.12794748397e-05
ko04924	Renin secretion	29/1173	86/7206	8.50971086826e-05
ko05110	Vibrio cholerae infection	23/1173	63/7206	8.9408475501e-05
ko04621	NOD-like receptor signaling pathway	9/1173	157/7206	0.000105012343284
ko04745	Phototransduction - fly	16/1173	38/7206	0.000136947311562
ko03008	Ribosome biogenesis in eukaryotes	2/1173	79/7206	0.000171640997083
ko04014	Ras signaling pathway	69/1173	279/7206	0.000247969540399
ko04072	Phospholipase D signaling pathway	52/1173	197/7206	0.000258058659496
ko04120	Ubiquitin mediated proteolysis	8/1173	138/7206	0.000267322893765
ko04915	Estrogen signaling pathway	38/1173	131/7206	0.000274808827793
ko04976	Bile secretion	26/1173	80/7206	0.000331064372712
ko05169	Epstein-Barr virus infection	16/1173	206/7206	0.000367053945068
ko05140	Leishmaniasis	2/1173	75/7206	0.000392078637605
ko05205	Proteoglycans in cancer	24/1173	271/7206	0.000402360217731
ko04064	NF-kappa B signaling pathway	4/1173	96/7206	0.000404771378717
ko04260	Cardiac muscle contraction	30/1173	98/7206	0.00044414595568
ko04923	Regulation of lipolysis in adipocytes	25/1173	77/7206	0.000463275933255
ko04750	Inflammatory mediator regulation of TRP channels	35/1173	122/7206	0.000466862784505
ko04730	Long-term depression	25/1173	78/7206	0.000524723038468
ko05161	Hepatitis B	13/1173	173/7206	0.000798261347863
ko04626	Plant-pathogen interaction	9/1173	18/7206	0.000932657176484
ko04110	Cell cycle	10/1173	145/7206	0.00130155007673
ko04612	Antigen processing and presentation	3/1173	77/7206	0.00155511286584
ko04371	Apelin signaling pathway	45/1173	177/7206	0.0018200580735
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1173	59/7206	0.00217143055547
ko05162	Measles	8/1173	120/7206	0.00252975236031
ko00240	Pyrimidine metabolism	7/1173	110/7206	0.00258257425743
ko00330	Arginine and proline metabolism	2/1173	61/7206	0.00265515128526
ko00260	Glycine, serine and threonine metabolism	1/1173	48/7206	0.00296115290027
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1173	14/7206	0.00354487808188
ko04146	Peroxisome	5/1173	89/7206	0.00357386858641
ko04964	Proximal tubule bicarbonate reclamation	11/1173	29/7206	0.0040883721798
ko03420	Nucleotide excision repair	1/1173	46/7206	0.0044280186568
ko05321	Inflammatory bowel disease (IBD)	2/1173	56/7206	0.00571451505817
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1173	100/7206	0.00591537690192
ko03022	Basal transcription factors	1/1173	44/7206	0.00668367238053
ko05144	Malaria	1/1173	45/7206	0.00694155441822
ko00071	Fatty acid degradation	1/1173	45/7206	0.00694155441822
ko03018	RNA degradation	5/1173	84/7206	0.00696166851664
ko00480	Glutathione metabolism	2/1173	55/7206	0.00880356953149
ko00562	Inositol phosphate metabolism	24/1173	89/7206	0.00896596378391
ko04622	RIG-I-like receptor signaling pathway	3/1173	62/7206	0.00926918332428
ko04640	Hematopoietic cell lineage	3/1173	64/7206	0.00953957629129
ko05131	Shigellosis	5/1173	82/7206	0.0097445316241
ko00310	Lysine degradation	4/1173	73/7206	0.0098083849686
ko04630	Jak-STAT signaling pathway	11/1173	132/7206	0.0118534741203
ko00380	Tryptophan metabolism	2/1173	50/7206	0.0121526843323
ko00590	Arachidonic acid metabolism	2/1173	52/7206	0.0125491431315
ko04657	IL-17 signaling pathway	6/1173	87/7206	0.0128558136704
ko05133	Pertussis	6/1173	87/7206	0.0128558136704
ko00630	Glyoxylate and dicarboxylate metabolism	1/1173	38/7206	0.0149280573238
ko03410	Base excision repair	1/1173	38/7206	0.0149280573238
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1173	40/7206	0.0156029877293
ko04916	Melanogenesis	34/1173	142/7206	0.0157266522811
ko04658	Th1 and Th2 cell differentiation	7/1173	96/7206	0.0168952781919
ko05219	Bladder cancer	2/1173	48/7206	0.0176163563013
ko04912	GnRH signaling pathway	30/1173	122/7206	0.0179677024981
ko05145	Toxoplasmosis	11/1173	126/7206	0.0200277590016
ko04114	Oocyte meiosis	33/1173	139/7206	0.020052166768
ko04270	Vascular smooth muscle contraction	36/1173	154/7206	0.0201215656242
ko04710	Circadian rhythm	13/1173	43/7206	0.0205974925955
ko00982	Drug metabolism - cytochrome P450	1/1173	37/7206	0.0227926288079
ko04015	Rap1 signaling pathway	59/1173	278/7206	0.0253028782549
ko04115	p53 signaling pathway	5/1173	74/7206	0.0253844386179
ko04918	Thyroid hormone synthesis	22/1173	86/7206	0.0263186550743
ko00280	Valine, leucine and isoleucine degradation	3/1173	54/7206	0.0265466121072
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1173	92/7206	0.0316763479556
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1173	182/7206	0.0321376455577
ko04510	Focal adhesion	27/1173	240/7206	0.0324826713452
ko05231	Choline metabolism in cancer	31/1173	134/7206	0.0336356808884
ko04214	Apoptosis - fly	5/1173	72/7206	0.0351268796108
ko05215	Prostate cancer	10/1173	111/7206	0.0374087523722
ko04922	Glucagon signaling pathway	30/1173	128/7206	0.0388834624982
ko04930	Type II diabetes mellitus	15/1173	54/7206	0.0390198500046
ko05166	HTLV-I infection	35/1173	292/7206	0.0429329585192
ko04711	Circadian rhythm - fly	5/1173	13/7206	0.0466376498774
ko03320	PPAR signaling pathway	5/1173	69/7206	0.0472924020056
ko05206	MicroRNAs in cancer	19/1173	177/7206	0.0493428026829