ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	78/614	145/7206	3.75288625534e-46
ko04110	Cell cycle	57/614	145/7206	8.67298056505e-25
ko03013	RNA transport	59/614	166/7206	5.75838047341e-23
ko03030	DNA replication	27/614	38/7206	3.80234015087e-21
ko04111	Cell cycle - yeast	41/614	90/7206	5.44169516565e-21
ko05322	Systemic lupus erythematosus	52/614	151/7206	1.23537116861e-19
ko03008	Ribosome biogenesis in eukaryotes	35/614	79/7206	1.32400606977e-17
ko03440	Homologous recombination	25/614	41/7206	3.21501942262e-17
ko03460	Fanconi anemia pathway	26/614	51/7206	3.02831502401e-15
ko04113	Meiosis - yeast	30/614	70/7206	8.80396746804e-15
ko03430	Mismatch repair	16/614	22/7206	2.94935218074e-13
ko03420	Nucleotide excision repair	22/614	46/7206	2.294888291e-12
ko00240	Pyrimidine metabolism	34/614	110/7206	1.03437572474e-11
ko03410	Base excision repair	19/614	38/7206	2.7550544523e-11
ko05034	Alcoholism	52/614	238/7206	1.0399500007e-10
ko04144	Endocytosis	3/614	342/7206	2.80909840905e-10
ko04020	Calcium signaling pathway	1/614	265/7206	1.64929935755e-09
ko03018	RNA degradation	25/614	84/7206	1.40697289197e-08
ko03022	Basal transcription factors	16/614	44/7206	2.75730454652e-07
ko04024	cAMP signaling pathway	4/614	279/7206	4.90005867015e-07
ko05203	Viral carcinogenesis	49/614	277/7206	7.73117972066e-07
ko04151	PI3K-Akt signaling pathway	10/614	390/7206	1.40067249309e-06
ko04510	Focal adhesion	3/614	240/7206	1.52306981209e-06
ko03020	RNA polymerase	12/614	29/7206	1.76308236527e-06
ko03015	mRNA surveillance pathway	23/614	93/7206	2.06227665383e-06
ko04261	Adrenergic signaling in cardiomyocytes	2/614	205/7206	3.06416980491e-06
ko04921	Oxytocin signaling pathway	2/614	209/7206	3.28495774107e-06
ko04723	Retrograde endocannabinoid signaling	1/614	175/7206	5.95553168959e-06
ko04072	Phospholipase D signaling pathway	2/614	197/7206	6.6790257791e-06
ko04022	cGMP-PKG signaling pathway	3/614	216/7206	9.98565969455e-06
ko04725	Cholinergic synapse	1/614	160/7206	1.88910159765e-05
ko04728	Dopaminergic synapse	2/614	185/7206	2.21101624133e-05
ko04724	Glutamatergic synapse	1/614	152/7206	2.7056699174e-05
ko04270	Vascular smooth muscle contraction	1/614	154/7206	2.72474139122e-05
ko05012	Parkinson's disease	1/614	155/7206	2.78004166083e-05
ko04010	MAPK signaling pathway	9/614	321/7206	3.50227756612e-05
ko04114	Oocyte meiosis	27/614	139/7206	3.91290378109e-05
ko04810	Regulation of actin cytoskeleton	6/614	264/7206	3.97948379897e-05
ko04060	Cytokine-cytokine receptor interaction	3/614	191/7206	6.32476056666e-05
ko05152	Tuberculosis	3/614	187/7206	9.1251122095e-05
ko04530	Tight junction	5/614	228/7206	9.47330449835e-05
ko04380	Osteoclast differentiation	1/614	134/7206	0.00013053422542
ko04932	Non-alcoholic fatty liver disease (NAFLD)	3/614	182/7206	0.00013118838838
ko04713	Circadian entrainment	1/614	136/7206	0.000133238887365
ko04726	Serotonergic synapse	1/614	137/7206	0.000136752178789
ko05166	HTLV-I infection	44/614	292/7206	0.000154877538635
ko04062	Chemokine signaling pathway	4/614	201/7206	0.000162735200995
ko04015	Rap1 signaling pathway	8/614	278/7206	0.00016746427804
ko04014	Ras signaling pathway	8/614	279/7206	0.000168627041507
ko04371	Apelin signaling pathway	3/614	177/7206	0.000188359274771
ko05142	Chagas disease (American trypanosomiasis)	1/614	130/7206	0.000193556053535
ko04514	Cell adhesion molecules (CAMs)	1/614	130/7206	0.000193556053535
ko04915	Estrogen signaling pathway	1/614	131/7206	0.000195876717427
ko05160	Hepatitis C	2/614	153/7206	0.000203473835639
ko04660	T cell receptor signaling pathway	1/614	124/7206	0.000286145640981
ko05145	Toxoplasmosis	1/614	126/7206	0.000288060929423
ko00190	Oxidative phosphorylation	1/614	127/7206	0.000293497371795
ko04914	Progesterone-mediated oocyte maturation	20/614	104/7206	0.000500366178421
ko04071	Sphingolipid signaling pathway	3/614	162/7206	0.000552553394367
ko04611	Platelet activation	3/614	163/7206	0.000552961665318
ko00230	Purine metabolism	31/614	194/7206	0.000577218058346
ko04120	Ubiquitin mediated proteolysis	24/614	138/7206	0.000602748795164
ko04911	Insulin secretion	1/614	117/7206	0.000630783315457
ko05202	Transcriptional misregulation in cancer	30/614	188/7206	0.000768461277985
ko04722	Neurotrophin signaling pathway	3/614	160/7206	0.000804106880701
ko04933	AGE-RAGE signaling pathway in diabetic complications	2/614	135/7206	0.000899918903804
ko04727	GABAergic synapse	1/614	110/7206	0.000917967570722
ko04070	Phosphatidylinositol signaling system	1/614	112/7206	0.000924955940322
ko05167	Kaposi's sarcoma-associated herpesvirus infection	5/614	191/7206	0.00140974502202
ko04142	Lysosome	3/614	151/7206	0.00164341146868
ko04141	Protein processing in endoplasmic reticulum	5/614	184/7206	0.00192749886135
ko04152	AMPK signaling pathway	4/614	161/7206	0.00251178152632
ko04145	Phagosome	4/614	162/7206	0.00251767929653
ko04360	Axon guidance	8/614	233/7206	0.00266428462057
ko04750	Inflammatory mediator regulation of TRP channels	2/614	122/7206	0.00273042753416
ko04971	Gastric acid secretion	1/614	98/7206	0.00294129792865
ko04620	Toll-like receptor signaling pathway	1/614	100/7206	0.00307825865268
ko05231	Choline metabolism in cancer	3/614	134/7206	0.00449585189197
ko04670	Leukocyte transendothelial migration	4/614	151/7206	0.00486249434544
ko05205	Proteoglycans in cancer	11/614	271/7206	0.00527136043446
ko05032	Morphine addiction	2/614	110/7206	0.00552278961855
ko04972	Pancreatic secretion	2/614	111/7206	0.00553063294213
ko05133	Pertussis	1/614	87/7206	0.00624816846996
ko04662	B cell receptor signaling pathway	1/614	88/7206	0.00627391795819
ko04922	Glucagon signaling pathway	3/614	128/7206	0.00631437255444
ko04540	Gap junction	3/614	128/7206	0.00631437255444
ko04146	Peroxisome	1/614	89/7206	0.00635456941453
ko00562	Inositol phosphate metabolism	1/614	89/7206	0.00635456941453
ko03450	Non-homologous end-joining	5/614	15/7206	0.00644484596398
ko04630	Jak-STAT signaling pathway	3/614	132/7206	0.00655598551392
ko05031	Amphetamine addiction	1/614	91/7206	0.00668449089885
ko04925	Aldosterone synthesis and secretion	2/614	105/7206	0.00789364427739
ko04659	Th17 cell differentiation	2/614	106/7206	0.00789530691677
ko04012	ErbB signaling pathway	2/614	109/7206	0.00822936728416
ko04137	Mitophagy - animal	1/614	82/7206	0.00913690188481
ko04924	Renin secretion	1/614	86/7206	0.00967423768669
ko04910	Insulin signaling pathway	6/614	172/7206	0.0124106018591
ko04931	Insulin resistance	4/614	137/7206	0.0128100626237
ko04730	Long-term depression	1/614	78/7206	0.0133432111704
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1/614	79/7206	0.0134502974693
ko04512	ECM-receptor interaction	1/614	79/7206	0.0134502974693
ko04721	Synaptic vesicle cycle	1/614	80/7206	0.0136673158729
ko04740	Olfactory transduction	1/614	80/7206	0.0136673158729
ko05211	Renal cell carcinoma	2/614	96/7206	0.0159785820266
ko04658	Th1 and Th2 cell differentiation	2/614	96/7206	0.0159785820266
ko04650	Natural killer cell mediated cytotoxicity	2/614	97/7206	0.0160535112999
ko05132	Salmonella infection	2/614	98/7206	0.016230543011
ko04720	Long-term potentiation	2/614	99/7206	0.0165103567054
ko00564	Glycerophospholipid metabolism	2/614	99/7206	0.0165103567054
ko05030	Cocaine addiction	1/614	73/7206	0.01942615454
ko00010	Glycolysis / Gluconeogenesis	1/614	74/7206	0.0195420109058
ko04210	Apoptosis	7/614	180/7206	0.020882816754
ko04140	Autophagy - animal	6/614	164/7206	0.0224440822081
ko01200	Carbon metabolism	4/614	128/7206	0.0241158415465
ko05168	Herpes simplex infection	24/614	182/7206	0.0302779664389
ko04918	Thyroid hormone synthesis	2/614	86/7206	0.0319812976429
ko04666	Fc gamma R-mediated phagocytosis	4/614	122/7206	0.0326599415682
ko05323	Rheumatoid arthritis	2/614	89/7206	0.0328186349546
ko05418	Fluid shear stress and atherosclerosis	7/614	173/7206	0.0370199655947
ko04138	Autophagy - yeast	2/614	81/7206	0.0450223710131
ko05162	Measles	4/614	120/7206	0.0453662352628
ko05100	Bacterial invasion of epithelial cells	3/614	99/7206	0.0455632788975
ko05164	Influenza A	7/614	167/7206	0.047873883794
ko04068	FoxO signaling pathway	7/614	167/7206	0.047873883794