ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 66/308 145/7206 3.53270415187e-53 ko03013 RNA transport 34/308 166/7206 8.21548963893e-15 ko04110 Cell cycle 31/308 145/7206 3.92680119772e-14 ko04111 Cell cycle - yeast 24/308 90/7206 1.94701735624e-13 ko03460 Fanconi anemia pathway 15/308 51/7206 1.63604091657e-09 ko04113 Meiosis - yeast 17/308 70/7206 3.44109904305e-09 ko03015 mRNA surveillance pathway 19/308 93/7206 9.04244497411e-09 ko03030 DNA replication 12/308 38/7206 2.99234765727e-08 ko03410 Base excision repair 11/308 38/7206 3.11405258591e-07 ko03440 Homologous recombination 11/308 41/7206 7.28692061554e-07 ko03018 RNA degradation 15/308 84/7206 2.10840762797e-06 ko04144 Endocytosis 1/308 342/7206 6.81741509694e-06 ko03022 Basal transcription factors 10/308 44/7206 1.1948405887e-05 ko00240 Pyrimidine metabolism 16/308 110/7206 1.52717697054e-05 ko05168 Herpes simplex infection 20/308 182/7206 9.05896993777e-05 ko03420 Nucleotide excision repair 9/308 46/7206 0.000115268148865 ko03008 Ribosome biogenesis in eukaryotes 12/308 79/7206 0.000116918835704 ko04015 Rap1 signaling pathway 2/308 278/7206 0.000725503739356 ko04024 cAMP signaling pathway 2/308 279/7206 0.000728355646622 ko04014 Ras signaling pathway 2/308 279/7206 0.000728355646622 ko04530 Tight junction 1/308 228/7206 0.000739373020002 ko04360 Axon guidance 1/308 233/7206 0.000752470549734 ko04114 Oocyte meiosis 15/308 139/7206 0.000827881220759 ko04151 PI3K-Akt signaling pathway 5/308 390/7206 0.00111943829163 ko05203 Viral carcinogenesis 24/308 277/7206 0.00114541245161 ko04810 Regulation of actin cytoskeleton 2/308 264/7206 0.00155717288068 ko04022 cGMP-PKG signaling pathway 1/308 216/7206 0.00163923837301 ko03430 Mismatch repair 5/308 22/7206 0.00199418674024 ko04120 Ubiquitin mediated proteolysis 14/308 138/7206 0.00221765635225 ko04261 Adrenergic signaling in cardiomyocytes 1/308 205/7206 0.00235018181552 ko04510 Focal adhesion 2/308 240/7206 0.00307681993787 ko04072 Phospholipase D signaling pathway 1/308 197/7206 0.00347027908391 ko04728 Dopaminergic synapse 1/308 185/7206 0.00493741666791 ko05152 Tuberculosis 1/308 187/7206 0.00501294941418 ko05205 Proteoglycans in cancer 3/308 271/7206 0.00514698562442 ko03020 RNA polymerase 5/308 29/7206 0.00704043170637 ko05169 Epstein-Barr virus infection 17/308 206/7206 0.00803124414425 ko04921 Oxytocin signaling pathway 2/308 209/7206 0.00885881100866 ko04914 Progesterone-mediated oocyte maturation 10/308 104/7206 0.0131007623244 ko04270 Vascular smooth muscle contraction 1/308 154/7206 0.0149437545829 ko04725 Cholinergic synapse 1/308 160/7206 0.0154276559383 ko05202 Transcriptional misregulation in cancer 15/308 188/7206 0.0167872209835 ko05166 HTLV-I infection 21/308 292/7206 0.017334465701 ko04670 Leukocyte transendothelial migration 1/308 151/7206 0.0223586612965 ko05206 MicroRNAs in cancer 14/308 177/7206 0.0226809425137 ko04010 MAPK signaling pathway 6/308 321/7206 0.0237202685877 ko04310 Wnt signaling pathway 2/308 181/7206 0.0248762994328 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/308 182/7206 0.0248935497585 ko04141 Protein processing in endoplasmic reticulum 2/308 184/7206 0.0250351545298 ko04931 Insulin resistance 1/308 137/7206 0.0311773480149 ko04726 Serotonergic synapse 1/308 137/7206 0.0311773480149 ko00310 Lysine degradation 7/308 73/7206 0.035622761421 ko04371 Apelin signaling pathway 2/308 177/7206 0.0356400741073 ko05322 Systemic lupus erythematosus 12/308 151/7206 0.0378833350687 ko04115 p53 signaling pathway 7/308 74/7206 0.0379661154831 ko01200 Carbon metabolism 1/308 128/7206 0.0448891504389 ko04540 Gap junction 1/308 128/7206 0.0448891504389 ko04915 Estrogen signaling pathway 1/308 131/7206 0.0457281535154 ko00230 Purine metabolism 14/308 194/7206 0.0470582690015 ko05231 Choline metabolism in cancer 1/308 134/7206 0.0472331893622 ko04071 Sphingolipid signaling pathway 2/308 162/7206 0.0487168330894 ko04152 AMPK signaling pathway 2/308 161/7206 0.0487212399761 ko04611 Platelet activation 2/308 163/7206 0.0487749418485 ko04140 Autophagy - animal 2/308 164/7206 0.0488953478982 ko04062 Chemokine signaling pathway 3/308 201/7206 0.0494410909757