ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1020	423/7206	6.97652796275e-49
ko04724	Glutamatergic synapse	85/1020	152/7206	3.33929003158e-34
ko05033	Nicotine addiction	47/1020	56/7206	1.02688541341e-31
ko05032	Morphine addiction	66/1020	110/7206	3.11396495594e-29
ko04727	GABAergic synapse	64/1020	110/7206	2.6904674991e-27
ko04713	Circadian entrainment	70/1020	136/7206	2.28157822357e-25
ko04725	Cholinergic synapse	74/1020	160/7206	4.53465483479e-23
ko04728	Dopaminergic synapse	80/1020	185/7206	1.59531264482e-22
ko04723	Retrograde endocannabinoid signaling	76/1020	175/7206	1.40044326781e-21
ko04721	Synaptic vesicle cycle	46/1020	80/7206	1.22677740569e-19
ko04024	cAMP signaling pathway	97/1020	279/7206	8.28054309054e-19
ko04911	Insulin secretion	54/1020	117/7206	4.47164882026e-17
ko04020	Calcium signaling pathway	87/1020	265/7206	4.01472801521e-15
ko04742	Taste transduction	34/1020	61/7206	2.75789431798e-14
ko04726	Serotonergic synapse	55/1020	137/7206	3.83755102448e-14
ko04744	Phototransduction	25/1020	36/7206	5.72831970154e-14
ko04921	Oxytocin signaling pathway	72/1020	209/7206	5.83736041016e-14
ko04261	Adrenergic signaling in cardiomyocytes	69/1020	205/7206	6.36607581698e-13
ko04720	Long-term potentiation	42/1020	99/7206	4.85314123897e-12
ko05031	Amphetamine addiction	39/1020	91/7206	1.94160252789e-11
ko04970	Salivary secretion	37/1020	95/7206	1.69873318054e-09
ko03040	Spliceosome	1/1020	145/7206	9.07880832491e-09
ko04925	Aldosterone synthesis and secretion	38/1020	105/7206	1.13856307507e-08
ko05030	Cocaine addiction	29/1020	73/7206	5.91382650604e-08
ko04971	Gastric acid secretion	34/1020	98/7206	2.19773316323e-07
ko05168	Herpes simplex infection	5/1020	182/7206	2.46383858061e-07
ko04360	Axon guidance	62/1020	233/7206	4.26696837347e-07
ko05203	Viral carcinogenesis	14/1020	277/7206	1.02828247231e-06
ko04740	Olfactory transduction	28/1020	80/7206	2.10412528024e-06
ko04060	Cytokine-cytokine receptor interaction	7/1020	191/7206	2.44552016567e-06
ko04010	MAPK signaling pathway	76/1020	321/7206	3.5543522258e-06
ko04022	cGMP-PKG signaling pathway	56/1020	216/7206	3.66940353842e-06
ko04540	Gap junction	38/1020	128/7206	4.38772388877e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1020	74/7206	4.46736024298e-06
ko04972	Pancreatic secretion	34/1020	111/7206	6.35349148652e-06
ko03013	RNA transport	6/1020	166/7206	1.29186793491e-05
ko04966	Collecting duct acid secretion	13/1020	26/7206	1.47046078583e-05
ko05322	Systemic lupus erythematosus	5/1020	151/7206	1.50735410092e-05
ko04730	Long-term depression	26/1020	78/7206	1.96470880054e-05
ko04141	Protein processing in endoplasmic reticulum	8/1020	184/7206	2.22128934184e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1020	79/7206	2.26596692103e-05
ko04745	Phototransduction - fly	16/1020	38/7206	2.3888337454e-05
ko05414	Dilated cardiomyopathy	33/1020	112/7206	2.53776718336e-05
ko05164	Influenza A	7/1020	167/7206	4.034436505e-05
ko04072	Phospholipase D signaling pathway	49/1020	197/7206	4.53756888902e-05
ko04260	Cardiac muscle contraction	29/1020	98/7206	6.00725024208e-05
ko04120	Ubiquitin mediated proteolysis	5/1020	138/7206	6.3180183715e-05
ko04621	NOD-like receptor signaling pathway	7/1020	157/7206	0.000110705523435
ko04915	Estrogen signaling pathway	35/1020	131/7206	0.000121852926237
ko04070	Phosphatidylinositol signaling system	31/1020	112/7206	0.000166052283495
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1020	14/7206	0.000212944346755
ko04514	Cell adhesion molecules (CAMs)	34/1020	130/7206	0.000298744938559
ko05110	Vibrio cholerae infection	20/1020	63/7206	0.000339464789169
ko05162	Measles	5/1020	120/7206	0.000522737980987
ko04976	Bile secretion	23/1020	80/7206	0.000568581211718
ko04924	Renin secretion	24/1020	86/7206	0.000831978828109
ko04750	Inflammatory mediator regulation of TRP channels	31/1020	122/7206	0.000896162983143
ko03008	Ribosome biogenesis in eukaryotes	2/1020	79/7206	0.000952148510345
ko04014	Ras signaling pathway	59/1020	279/7206	0.00113187070342
ko05205	Proteoglycans in cancer	21/1020	271/7206	0.00131546222036
ko05140	Leishmaniasis	2/1020	75/7206	0.00139581398596
ko04612	Antigen processing and presentation	2/1020	77/7206	0.00142594640577
ko04110	Cell cycle	8/1020	145/7206	0.00155401320142
ko04626	Plant-pathogen interaction	8/1020	18/7206	0.0018332027253
ko04912	GnRH signaling pathway	30/1020	122/7206	0.00225828619934
ko03018	RNA degradation	3/1020	84/7206	0.00244533329229
ko04923	Regulation of lipolysis in adipocytes	21/1020	77/7206	0.00251567047918
ko04064	NF-kappa B signaling pathway	4/1020	96/7206	0.00276680861896
ko05169	Epstein-Barr virus infection	15/1020	206/7206	0.00307393521574
ko05161	Hepatitis B	12/1020	173/7206	0.00393920226619
ko04964	Proximal tubule bicarbonate reclamation	10/1020	29/7206	0.00480210095754
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1020	182/7206	0.0048047344163
ko00480	Glutathione metabolism	1/1020	55/7206	0.00525517831713
ko04146	Peroxisome	4/1020	89/7206	0.00538219462588
ko00240	Pyrimidine metabolism	6/1020	110/7206	0.00549203733303
ko04640	Hematopoietic cell lineage	2/1020	64/7206	0.00628837290864
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1020	59/7206	0.00774824628609
ko00590	Arachidonic acid metabolism	1/1020	52/7206	0.00776685274739
ko04371	Apelin signaling pathway	38/1020	177/7206	0.00832136534391
ko00330	Arginine and proline metabolism	2/1020	61/7206	0.00911360785178
ko04214	Apoptosis - fly	3/1020	72/7206	0.0101116975965
ko00310	Lysine degradation	3/1020	73/7206	0.0102621133378
ko04630	Jak-STAT signaling pathway	9/1020	132/7206	0.0114543446005
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1020	15/7206	0.0126697412408
ko04062	Chemokine signaling pathway	41/1020	201/7206	0.0134482087211
ko03022	Basal transcription factors	1/1020	44/7206	0.0161224594016
ko05144	Malaria	1/1020	45/7206	0.0163230274422
ko00071	Fatty acid degradation	1/1020	45/7206	0.0163230274422
ko03420	Nucleotide excision repair	1/1020	46/7206	0.0169211501717
ko05034	Alcoholism	47/1020	238/7206	0.0175861503172
ko04930	Type II diabetes mellitus	14/1020	54/7206	0.018274455007
ko04114	Oocyte meiosis	30/1020	139/7206	0.0186684096371
ko05321	Inflammatory bowel disease (IBD)	2/1020	56/7206	0.0192052003062
ko04918	Thyroid hormone synthesis	20/1020	86/7206	0.0194084084983
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1020	100/7206	0.0195063046863
ko04657	IL-17 signaling pathway	5/1020	87/7206	0.0197341791123
ko01524	Platinum drug resistance	4/1020	76/7206	0.0202780256319
ko01200	Carbon metabolism	9/1020	128/7206	0.0203052715442
ko04916	Melanogenesis	30/1020	142/7206	0.0205067663574
ko05166	HTLV-I infection	28/1020	292/7206	0.0205600599892
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1020	26/7206	0.0231816504035
ko00140	Steroid hormone biosynthesis	1/1020	41/7206	0.0238797700125
ko04670	Leukocyte transendothelial migration	12/1020	151/7206	0.0246788627467
ko04270	Vascular smooth muscle contraction	32/1020	154/7206	0.0254786126373
ko04658	Th1 and Th2 cell differentiation	6/1020	96/7206	0.0257104615184
ko00280	Valine, leucine and isoleucine degradation	2/1020	54/7206	0.0283517845353
ko00562	Inositol phosphate metabolism	20/1020	89/7206	0.0310801467967
ko04350	TGF-beta signaling pathway	7/1020	103/7206	0.0315501403481
ko00630	Glyoxylate and dicarboxylate metabolism	1/1020	38/7206	0.0352956513086
ko05418	Fluid shear stress and atherosclerosis	15/1020	173/7206	0.03557947076
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1020	40/7206	0.0366838967168
ko05131	Shigellosis	5/1020	82/7206	0.0367871452346
ko05016	Huntington's disease	20/1020	215/7206	0.0368967436974
ko04210	Apoptosis	16/1020	180/7206	0.0394049346572
ko00380	Tryptophan metabolism	2/1020	50/7206	0.0394420014482
ko04622	RIG-I-like receptor signaling pathway	3/1020	62/7206	0.0412733169641
ko00910	Nitrogen metabolism	6/1020	19/7206	0.0417967120654
ko04015	Rap1 signaling pathway	51/1020	278/7206	0.0437031397107