ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 63/593 152/7206 9.07493046857e-30 ko04080 Neuroactive ligand-receptor interaction 109/593 423/7206 1.78188561707e-29 ko05033 Nicotine addiction 35/593 56/7206 1.09744084672e-24 ko04727 GABAergic synapse 43/593 110/7206 2.08131690973e-19 ko05032 Morphine addiction 40/593 110/7206 7.9688553691e-17 ko04713 Circadian entrainment 43/593 136/7206 1.96032714419e-15 ko04728 Dopaminergic synapse 51/593 185/7206 2.50779155575e-15 ko04721 Synaptic vesicle cycle 32/593 80/7206 4.42804415734e-15 ko04723 Retrograde endocannabinoid signaling 49/593 175/7206 4.63594755353e-15 ko04024 cAMP signaling pathway 57/593 279/7206 7.5569453897e-11 ko05030 Cocaine addiction 25/593 73/7206 2.48954842515e-10 ko04725 Cholinergic synapse 39/593 160/7206 3.2188403748e-10 ko04911 Insulin secretion 32/593 117/7206 5.79828627273e-10 ko04726 Serotonergic synapse 33/593 137/7206 1.05866848695e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 23/593 74/7206 1.1134150027e-08 ko04742 Taste transduction 20/593 61/7206 3.70487402754e-08 ko04261 Adrenergic signaling in cardiomyocytes 41/593 205/7206 7.38729056696e-08 ko04010 MAPK signaling pathway 55/593 321/7206 1.08083898551e-07 ko05031 Amphetamine addiction 24/593 91/7206 1.80530827796e-07 ko04514 Cell adhesion molecules (CAMs) 29/593 130/7206 4.87473333961e-07 ko04921 Oxytocin signaling pathway 38/593 209/7206 2.39201072284e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/593 79/7206 3.82742426167e-06 ko04260 Cardiac muscle contraction 22/593 98/7206 1.0579257986e-05 ko04730 Long-term depression 18/593 78/7206 4.51958125322e-05 ko04020 Calcium signaling pathway 41/593 265/7206 8.3073916382e-05 ko03040 Spliceosome 1/593 145/7206 9.0777805515e-05 ko04720 Long-term potentiation 20/593 99/7206 0.000129187178567 ko04060 Cytokine-cytokine receptor interaction 3/593 191/7206 0.00013779024759 ko04360 Axon guidance 36/593 233/7206 0.000219638798899 ko04972 Pancreatic secretion 21/593 111/7206 0.00030055545177 ko05203 Viral carcinogenesis 8/593 277/7206 0.000318616722452 ko05414 Dilated cardiomyopathy 21/593 112/7206 0.000327201580693 ko03013 RNA transport 3/593 166/7206 0.000820784852302 ko05164 Influenza A 3/593 167/7206 0.000839206886007 ko04970 Salivary secretion 18/593 95/7206 0.000899940817802 ko05168 Herpes simplex infection 4/593 182/7206 0.000926658258882 ko05410 Hypertrophic cardiomyopathy (HCM) 18/593 100/7206 0.00135313524763 ko04120 Ubiquitin mediated proteolysis 2/593 138/7206 0.00139122887053 ko04072 Phospholipase D signaling pathway 29/593 197/7206 0.00216514513253 ko05322 Systemic lupus erythematosus 3/593 151/7206 0.00234123532826 ko05205 Proteoglycans in cancer 10/593 271/7206 0.00327160369896 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/593 14/7206 0.00396650127933 ko04621 NOD-like receptor signaling pathway 4/593 157/7206 0.00491452389643 ko04540 Gap junction 20/593 128/7206 0.00499098005551 ko04915 Estrogen signaling pathway 20/593 131/7206 0.00591156310273 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/593 59/7206 0.00783388508559 ko00240 Pyrimidine metabolism 2/593 110/7206 0.00798521916789 ko01200 Carbon metabolism 3/593 128/7206 0.00893314918057 ko04146 Peroxisome 1/593 89/7206 0.00976333618414 ko04014 Ras signaling pathway 35/593 279/7206 0.0103852828082 ko04930 Type II diabetes mellitus 10/593 54/7206 0.0115278172962 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/593 182/7206 0.0129240244118 ko03018 RNA degradation 1/593 84/7206 0.0141803705281 ko05034 Alcoholism 30/593 238/7206 0.0162400110863 ko04966 Collecting duct acid secretion 6/593 26/7206 0.0167808504493 ko05162 Measles 3/593 120/7206 0.0175990133273 ko04071 Sphingolipid signaling pathway 22/593 162/7206 0.0193878102998 ko04973 Carbohydrate digestion and absorption 8/593 42/7206 0.019394662652 ko05169 Epstein-Barr virus infection 8/593 206/7206 0.0196981874945 ko04612 Antigen processing and presentation 1/593 77/7206 0.0197939332052 ko03008 Ribosome biogenesis in eukaryotes 1/593 79/7206 0.0205682582564 ko04924 Renin secretion 13/593 86/7206 0.0279701261229 ko04964 Proximal tubule bicarbonate reclamation 6/593 29/7206 0.028083229615 ko04141 Protein processing in endoplasmic reticulum 7/593 184/7206 0.0282834596462 ko04214 Apoptosis - fly 1/593 72/7206 0.0287322555711 ko02024 Quorum sensing 4/593 15/7206 0.0297983585882 ko04925 Aldosterone synthesis and secretion 15/593 105/7206 0.0305966911797 ko04022 cGMP-PKG signaling pathway 27/593 216/7206 0.0312891213332 ko04217 Necroptosis 7/593 178/7206 0.0368137974919 ko04940 Type I diabetes mellitus 6/593 32/7206 0.0435137390419 ko00515 Mannose type O-glycan biosynthesis 5/593 25/7206 0.0496958688184