ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04721	Synaptic vesicle cycle	31/471	80/7206	5.18682668127e-17
ko05033	Nicotine addiction	23/471	56/7206	1.40555855799e-13
ko04727	GABAergic synapse	30/471	110/7206	7.29880422253e-12
ko04724	Glutamatergic synapse	35/471	152/7206	2.53353692454e-11
ko05032	Morphine addiction	29/471	110/7206	4.1104691097e-11
ko04728	Dopaminergic synapse	38/471	185/7206	1.31766767224e-10
ko04723	Retrograde endocannabinoid signaling	35/471	175/7206	1.55629934241e-09
ko04514	Cell adhesion molecules (CAMs)	26/471	130/7206	2.09518760922e-07
ko04080	Neuroactive ligand-receptor interaction	56/471	423/7206	2.36462066519e-07
ko04713	Circadian entrainment	26/471	136/7206	5.30984031848e-07
ko04725	Cholinergic synapse	28/471	160/7206	1.27452893959e-06
ko04911	Insulin secretion	22/471	117/7206	5.33108799639e-06
ko04744	Phototransduction	11/471	36/7206	1.11322991896e-05
ko04024	cAMP signaling pathway	37/471	279/7206	3.18341426921e-05
ko05030	Cocaine addiction	15/471	73/7206	5.81119967037e-05
ko04726	Serotonergic synapse	22/471	137/7206	6.95781609578e-05
ko05205	Proteoglycans in cancer	4/471	271/7206	0.000130102050372
ko04966	Collecting duct acid secretion	8/471	26/7206	0.0001716241603
ko04060	Cytokine-cytokine receptor interaction	2/471	191/7206	0.000489426146316
ko03040	Spliceosome	1/471	145/7206	0.0010098721002
ko05203	Viral carcinogenesis	6/471	277/7206	0.00113506742116
ko04261	Adrenergic signaling in cardiomyocytes	26/471	205/7206	0.00130980927591
ko04120	Ubiquitin mediated proteolysis	1/471	138/7206	0.00147471376699
ko04010	MAPK signaling pathway	36/471	321/7206	0.0016106739888
ko04611	Platelet activation	2/471	163/7206	0.00202805197379
ko04140	Autophagy - animal	2/471	164/7206	0.00203850559546
ko03013	RNA transport	2/471	166/7206	0.00208689917936
ko04972	Pancreatic secretion	16/471	111/7206	0.00269011481168
ko05014	Amyotrophic lateral sclerosis (ALS)	12/471	74/7206	0.00281608011578
ko04145	Phagosome	21/471	162/7206	0.0031234946059
ko01200	Carbon metabolism	1/471	128/7206	0.00320339609585
ko04961	Endocrine and other factor-regulated calcium reabsorption	10/471	59/7206	0.0044706154823
ko04211	Longevity regulating pathway	1/471	123/7206	0.00475413388521
ko04066	HIF-1 signaling pathway	1/471	123/7206	0.00475413388521
ko04360	Axon guidance	26/471	233/7206	0.00658436148462
ko05164	Influenza A	3/471	167/7206	0.00672920181763
ko04068	FoxO signaling pathway	3/471	167/7206	0.00672920181763
ko05110	Vibrio cholerae infection	10/471	63/7206	0.0072009153217
ko05120	Epithelial cell signaling in Helicobacter pylori infection	13/471	92/7206	0.00839994344076
ko04931	Insulin resistance	2/471	137/7206	0.00841474418217
ko04950	Maturity onset diabetes of the young	6/471	29/7206	0.00987613530505
ko04970	Salivary secretion	13/471	95/7206	0.0100443104954
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/471	14/7206	0.0106563522708
ko00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/471	8/7206	0.0121294600064
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/471	15/7206	0.0137948555975
ko05168	Herpes simplex infection	4/471	182/7206	0.0138427461206
ko05169	Epstein-Barr virus infection	5/471	206/7206	0.0138797739071
ko01521	EGFR tyrosine kinase inhibitor resistance	1/471	106/7206	0.0150167810514
ko05322	Systemic lupus erythematosus	3/471	151/7206	0.018382788077
ko04330	Notch signaling pathway	9/471	62/7206	0.018473375266
ko04146	Peroxisome	1/471	89/7206	0.0297108832444
ko04932	Non-alcoholic fatty liver disease (NAFLD)	5/471	182/7206	0.0326596067029
ko04260	Cardiac muscle contraction	12/471	98/7206	0.0354320272687
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	10/471	79/7206	0.0367978843333
ko00512	Mucin type O-glycan biosynthesis	5/471	29/7206	0.0376834070849
ko04964	Proximal tubule bicarbonate reclamation	5/471	29/7206	0.0376834070849
ko04137	Mitophagy - animal	1/471	82/7206	0.042869404182
ko03018	RNA degradation	1/471	84/7206	0.0431301879857
ko01230	Biosynthesis of amino acids	1/471	85/7206	0.0435207962488
ko05323	Rheumatoid arthritis	11/471	89/7206	0.0468031290041
ko04630	Jak-STAT signaling pathway	3/471	132/7206	0.0480747770743
ko00240	Pyrimidine metabolism	2/471	110/7206	0.0483242592312
ko05215	Prostate cancer	2/471	111/7206	0.0490237044414
ko05031	Amphetamine addiction	11/471	91/7206	0.0494705319856