ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 20/141 152/7206 9.51213664543e-12 ko05033 Nicotine addiction 10/141 56/7206 9.87253461728e-08 ko04713 Circadian entrainment 14/141 136/7206 3.48698562974e-07 ko04727 GABAergic synapse 12/141 110/7206 1.3438952827e-06 ko04728 Dopaminergic synapse 15/141 185/7206 2.8391404403e-06 ko05032 Morphine addiction 11/141 110/7206 8.87209582084e-06 ko05031 Amphetamine addiction 10/141 91/7206 9.94622757653e-06 ko05030 Cocaine addiction 9/141 73/7206 1.09148537393e-05 ko04720 Long-term potentiation 10/141 99/7206 2.11046534687e-05 ko04072 Phospholipase D signaling pathway 14/141 197/7206 2.80397032112e-05 ko04723 Retrograde endocannabinoid signaling 13/141 175/7206 3.45506049892e-05 ko05231 Choline metabolism in cancer 11/141 134/7206 5.73140822155e-05 ko04080 Neuroactive ligand-receptor interaction 21/141 423/7206 6.62874231798e-05 ko04024 cAMP signaling pathway 16/141 279/7206 0.000101520021845 ko04020 Calcium signaling pathway 15/141 265/7206 0.000195394793716 ko04914 Progesterone-mediated oocyte maturation 8/141 104/7206 0.000933365697876 ko04010 MAPK signaling pathway 15/141 321/7206 0.00145709358577 ko04070 Phosphatidylinositol signaling system 8/141 112/7206 0.00151164474392 ko04911 Insulin secretion 8/141 117/7206 0.00199783504946 ko04666 Fc gamma R-mediated phagocytosis 8/141 122/7206 0.00259981959644 ko04015 Rap1 signaling pathway 13/141 278/7206 0.00300833199714 ko04022 cGMP-PKG signaling pathway 11/141 216/7206 0.00328921752693 ko04923 Regulation of lipolysis in adipocytes 6/141 77/7206 0.00382788515732 ko04725 Cholinergic synapse 9/141 160/7206 0.00402696338448 ko04915 Estrogen signaling pathway 8/141 131/7206 0.00403300488262 ko04925 Aldosterone synthesis and secretion 7/141 105/7206 0.00436881255517 ko04360 Axon guidance 11/141 233/7206 0.00581959904872 ko04062 Chemokine signaling pathway 10/141 201/7206 0.00590058112299 ko04972 Pancreatic secretion 7/141 111/7206 0.00591866410678 ko05414 Dilated cardiomyopathy 7/141 112/7206 0.00621246539762 ko04213 Longevity regulating pathway - multiple species 6/141 86/7206 0.00658015559762 ko04742 Taste transduction 5/141 61/7206 0.00660229616759 ko04261 Adrenergic signaling in cardiomyocytes 10/141 205/7206 0.00675744842162 ko04371 Apelin signaling pathway 9/141 177/7206 0.00773213722614 ko00562 Inositol phosphate metabolism 6/141 89/7206 0.00775553046769 ko04973 Carbohydrate digestion and absorption 4/141 42/7206 0.00883757796105 ko04750 Inflammatory mediator regulation of TRP channels 7/141 122/7206 0.00978151254668 ko04211 Longevity regulating pathway 7/141 123/7206 0.0102066928487 ko04970 Salivary secretion 6/141 95/7206 0.0105490665624 ko01522 Endocrine resistance 7/141 124/7206 0.0106452209772 ko00515 Mannose type O-glycan biosynthesis 3/141 25/7206 0.0123083207082 ko00564 Glycerophospholipid metabolism 6/141 99/7206 0.012768370408 ko05014 Amyotrophic lateral sclerosis (ALS) 5/141 74/7206 0.0146198938106 ko00510 N-Glycan biosynthesis 4/141 50/7206 0.016132251921 ko00512 Mucin type O-glycan biosynthesis 3/141 29/7206 0.0184771095575 ko04011 MAPK signaling pathway - yeast 4/141 53/7206 0.0196148770366 ko04012 ErbB signaling pathway 6/141 109/7206 0.0197127559651 ko04921 Oxytocin signaling pathway 9/141 209/7206 0.0211264176924 ko04320 Dorso-ventral axis formation 3/141 31/7206 0.0220967576444 ko04918 Thyroid hormone synthesis 5/141 86/7206 0.0262806986343 ko04270 Vascular smooth muscle contraction 7/141 154/7206 0.0310879490292 ko04912 GnRH signaling pathway 6/141 122/7206 0.0320924552047 ko04913 Ovarian steroidogenesis 4/141 63/7206 0.0343971317144 ko00561 Glycerolipid metabolism 4/141 63/7206 0.0343971317144 ko04139 Mitophagy - yeast 3/141 37/7206 0.0351048095964 ko04540 Gap junction 6/141 128/7206 0.0392085984988 ko04611 Platelet activation 7/141 163/7206 0.0404186800133 ko04971 Gastric acid secretion 5/141 98/7206 0.0426588178519 ko04144 Endocytosis 12/141 342/7206 0.0433013599285