ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 35/354 191/7206 6.88625660915e-12 ko04380 Osteoclast differentiation 26/354 134/7206 1.09518708579e-09 ko04621 NOD-like receptor signaling pathway 28/354 157/7206 1.85214246649e-09 ko05164 Influenza A 27/354 167/7206 3.25182713584e-08 ko04064 NF-kappa B signaling pathway 19/354 96/7206 1.46667515601e-07 ko04668 TNF signaling pathway 21/354 120/7206 2.92964478386e-07 ko05140 Leishmaniasis 16/354 75/7206 4.92960413422e-07 ko04658 Th1 and Th2 cell differentiation 18/354 96/7206 7.31855383589e-07 ko05162 Measles 19/354 120/7206 5.14474020914e-06 ko05145 Toxoplasmosis 19/354 126/7206 1.06895951122e-05 ko05161 Hepatitis B 23/354 173/7206 1.11212371718e-05 ko04657 IL-17 signaling pathway 15/354 87/7206 1.80371446879e-05 ko05168 Herpes simplex infection 23/354 182/7206 2.57008018249e-05 ko00120 Primary bile acid biosynthesis 7/354 20/7206 2.894182363e-05 ko04217 Necroptosis 22/354 178/7206 5.43797150681e-05 ko04672 Intestinal immune network for IgA production 9/354 37/7206 5.50355151225e-05 ko04630 Jak-STAT signaling pathway 18/354 132/7206 7.2317989571e-05 ko04623 Cytosolic DNA-sensing pathway 9/354 41/7206 0.000130188352303 ko00140 Steroid hormone biosynthesis 9/354 41/7206 0.000130188352303 ko00350 Tyrosine metabolism 8/354 33/7206 0.000147465296129 ko05160 Hepatitis C 19/354 153/7206 0.000164398926748 ko04659 Th17 cell differentiation 15/354 106/7206 0.000189540182677 ko04210 Apoptosis 21/354 180/7206 0.000286878616547 ko05323 Rheumatoid arthritis 13/354 89/7206 0.000367525153693 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/354 191/7206 0.000477003969391 ko05340 Primary immunodeficiency 7/354 30/7206 0.000496365027852 ko04622 RIG-I-like receptor signaling pathway 10/354 62/7206 0.00078709072475 ko04660 T cell receptor signaling pathway 15/354 124/7206 0.00104326111767 ko04620 Toll-like receptor signaling pathway 13/354 100/7206 0.00114092628939 ko05321 Inflammatory bowel disease (IBD) 9/354 56/7206 0.0014682842618 ko04062 Chemokine signaling pathway 20/354 201/7206 0.00238783951825 ko04650 Natural killer cell mediated cytotoxicity 12/354 97/7206 0.00268221402281 ko04662 B cell receptor signaling pathway 11/354 88/7206 0.00367472969325 ko05330 Allograft rejection 5/354 24/7206 0.00545330744098 ko05142 Chagas disease (American trypanosomiasis) 14/354 130/7206 0.00586115354201 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/354 135/7206 0.00735296184366 ko04931 Insulin resistance 14/354 137/7206 0.00811357261771 ko00360 Phenylalanine metabolism 4/354 17/7206 0.00818728247323 ko05146 Amoebiasis 11/354 99/7206 0.00896179962438 ko05332 Graft-versus-host disease 4/354 18/7206 0.0101261134952 ko03040 Spliceosome 1/354 145/7206 0.0102840665127 ko00950 Isoquinoline alkaloid biosynthesis 3/354 10/7206 0.0108958829097 ko05320 Autoimmune thyroid disease 5/354 29/7206 0.0124640020667 ko04612 Antigen processing and presentation 9/354 77/7206 0.0126810655606 ko00590 Arachidonic acid metabolism 7/354 52/7206 0.0129227842576 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/354 4/7206 0.013517490933 ko00643 Styrene degradation 2/354 4/7206 0.013517490933 ko00983 Drug metabolism - other enzymes 6/354 42/7206 0.0158077526365 ko04550 Signaling pathways regulating pluripotency of stem cells 2/354 165/7206 0.0175229722434 ko04666 Fc gamma R-mediated phagocytosis 12/354 122/7206 0.0183864644067 ko04670 Leukocyte transendothelial migration 14/354 151/7206 0.0202534386641 ko01200 Carbon metabolism 1/354 128/7206 0.021434637547 ko05144 Malaria 6/354 45/7206 0.0217153727158 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/354 5/7206 0.02180132466 ko05152 Tuberculosis 16/354 187/7206 0.0255241031252 ko04390 Hippo signaling pathway 3/354 188/7206 0.025865804684 ko00500 Starch and sucrose metabolism 5/354 35/7206 0.0268252574221 ko05132 Salmonella infection 10/354 98/7206 0.0285181944077 ko04917 Prolactin signaling pathway 9/354 87/7206 0.0385065507133 ko05133 Pertussis 9/354 87/7206 0.0385065507133 ko02010 ABC transporters 5/354 39/7206 0.0406138422039 ko04611 Platelet activation 14/354 163/7206 0.0406363528183 ko04727 GABAergic synapse 1/354 110/7206 0.0442603633642 ko04360 Axon guidance 5/354 233/7206 0.0444588896113 ko04080 Neuroactive ligand-receptor interaction 12/354 423/7206 0.0474636295288 ko00401 Novobiocin biosynthesis 1/354 1/7206 0.0491257285598 ko04723 Retrograde endocannabinoid signaling 3/354 175/7206 0.0491363350554