ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1221	423/7206	1.72627122298e-45
ko04724	Glutamatergic synapse	89/1221	152/7206	1.24339439587e-31
ko05033	Nicotine addiction	48/1221	56/7206	1.58123863061e-29
ko05032	Morphine addiction	67/1221	110/7206	1.94135365277e-25
ko04727	GABAergic synapse	64/1221	110/7206	8.45960886467e-23
ko04713	Circadian entrainment	72/1221	136/7206	3.67404032808e-22
ko04721	Synaptic vesicle cycle	52/1221	80/7206	7.04511845613e-22
ko04728	Dopaminergic synapse	85/1221	185/7206	1.20788706414e-20
ko04725	Cholinergic synapse	75/1221	160/7206	5.7798159909e-19
ko04723	Retrograde endocannabinoid signaling	79/1221	175/7206	1.10028228512e-18
ko04742	Taste transduction	37/1221	61/7206	1.665769611e-14
ko04020	Calcium signaling pathway	96/1221	265/7206	1.78454000374e-14
ko04726	Serotonergic synapse	61/1221	137/7206	2.37286566218e-14
ko04024	cAMP signaling pathway	99/1221	279/7206	2.39336287049e-14
ko04911	Insulin secretion	55/1221	117/7206	2.73666105233e-14
ko04921	Oxytocin signaling pathway	76/1221	209/7206	7.00391785718e-12
ko05031	Amphetamine addiction	42/1221	91/7206	6.7544189127e-11
ko04720	Long-term potentiation	44/1221	99/7206	1.11686948768e-10
ko04744	Phototransduction	23/1221	36/7206	3.75074777744e-10
ko03010	Ribosome	1/1221	129/7206	1.52761899216e-09
ko03040	Spliceosome	2/1221	145/7206	1.60166802543e-09
ko04925	Aldosterone synthesis and secretion	41/1221	105/7206	5.06457024883e-08
ko04970	Salivary secretion	38/1221	95/7206	8.89180279e-08
ko04261	Adrenergic signaling in cardiomyocytes	65/1221	205/7206	1.30519512126e-07
ko03013	RNA transport	7/1221	166/7206	5.75740409294e-07
ko05168	Herpes simplex infection	9/1221	182/7206	1.09363921421e-06
ko05322	Systemic lupus erythematosus	6/1221	151/7206	1.48404794791e-06
ko04971	Gastric acid secretion	36/1221	98/7206	2.00498678852e-06
ko04966	Collecting duct acid secretion	15/1221	26/7206	3.00483599616e-06
ko05030	Cocaine addiction	29/1221	73/7206	4.12467548935e-06
ko04014	Ras signaling pathway	76/1221	279/7206	9.73671298663e-06
ko04070	Phosphatidylinositol signaling system	38/1221	112/7206	1.01824838832e-05
ko04360	Axon guidance	66/1221	233/7206	1.09674524492e-05
ko04621	NOD-like receptor signaling pathway	8/1221	157/7206	1.21280326448e-05
ko05203	Viral carcinogenesis	22/1221	277/7206	1.30541043243e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1221	74/7206	1.39672209965e-05
ko04141	Protein processing in endoplasmic reticulum	11/1221	184/7206	1.41851356346e-05
ko04514	Cell adhesion molecules (CAMs)	42/1221	130/7206	1.50130858446e-05
ko04022	cGMP-PKG signaling pathway	61/1221	216/7206	2.79399404811e-05
ko04972	Pancreatic secretion	37/1221	111/7206	2.98725077825e-05
ko04010	MAPK signaling pathway	83/1221	321/7206	3.55550923674e-05
ko04072	Phospholipase D signaling pathway	56/1221	197/7206	4.43207688327e-05
ko04730	Long-term depression	28/1221	78/7206	4.82375708369e-05
ko04745	Phototransduction - fly	17/1221	38/7206	5.63335011983e-05
ko05164	Influenza A	11/1221	167/7206	9.71349314261e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1221	79/7206	0.00011050059179
ko04060	Cytokine-cytokine receptor interaction	14/1221	191/7206	0.000121770691972
ko04110	Cell cycle	9/1221	145/7206	0.000187316070754
ko04750	Inflammatory mediator regulation of TRP channels	37/1221	122/7206	0.000217171189099
ko04740	Olfactory transduction	27/1221	80/7206	0.000232465444845
ko04710	Circadian rhythm	17/1221	43/7206	0.000352993590377
ko04120	Ubiquitin mediated proteolysis	9/1221	138/7206	0.000502538972964
ko05110	Vibrio cholerae infection	22/1221	63/7206	0.000523255050459
ko04612	Antigen processing and presentation	3/1221	77/7206	0.0006844380352
ko04540	Gap junction	37/1221	128/7206	0.000748146605123
ko00520	Amino sugar and nucleotide sugar metabolism	1/1221	55/7206	0.000842637960105
ko04064	NF-kappa B signaling pathway	5/1221	96/7206	0.000873258131231
ko05161	Hepatitis B	14/1221	173/7206	0.000953541998304
ko05140	Leishmaniasis	3/1221	75/7206	0.000992824834932
ko04371	Apelin signaling pathway	47/1221	177/7206	0.00108362943088
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1221	79/7206	0.00126131840616
ko04976	Bile secretion	25/1221	80/7206	0.00142458640054
ko04964	Proximal tubule bicarbonate reclamation	12/1221	29/7206	0.00162632212616
ko04915	Estrogen signaling pathway	36/1221	131/7206	0.00210673999119
ko04930	Type II diabetes mellitus	18/1221	54/7206	0.00297559458095
ko03022	Basal transcription factors	1/1221	44/7206	0.00428628912819
ko05144	Malaria	1/1221	45/7206	0.0043347223828
ko05162	Measles	9/1221	120/7206	0.00437215097266
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1221	59/7206	0.00437903656566
ko05169	Epstein-Barr virus infection	20/1221	206/7206	0.00447219674335
ko03420	Nucleotide excision repair	1/1221	46/7206	0.00456461347155
ko05205	Proteoglycans in cancer	29/1221	271/7206	0.0048350608965
ko04924	Renin secretion	25/1221	86/7206	0.00535092911053
ko05145	Toxoplasmosis	10/1221	126/7206	0.00544756063729
ko00280	Valine, leucine and isoleucine degradation	2/1221	54/7206	0.00554908666396
ko04922	Glucagon signaling pathway	34/1221	128/7206	0.00584958886767
ko04626	Plant-pathogen interaction	8/1221	18/7206	0.00586034254259
ko04217	Necroptosis	17/1221	178/7206	0.00612455260454
ko04622	RIG-I-like receptor signaling pathway	3/1221	62/7206	0.00629340679515
ko04630	Jak-STAT signaling pathway	11/1221	132/7206	0.00665036082764
ko05414	Dilated cardiomyopathy	30/1221	112/7206	0.00746293989976
ko04657	IL-17 signaling pathway	6/1221	87/7206	0.00914763013851
ko05133	Pertussis	6/1221	87/7206	0.00914763013851
ko04260	Cardiac muscle contraction	27/1221	98/7206	0.00922050284421
ko04610	Complement and coagulation cascades	5/1221	79/7206	0.00951734759524
ko04015	Rap1 signaling pathway	63/1221	278/7206	0.0114378230072
ko05219	Bladder cancer	2/1221	48/7206	0.0118390985995
ko04270	Vascular smooth muscle contraction	38/1221	154/7206	0.0123831664716
ko03018	RNA degradation	6/1221	84/7206	0.012506707098
ko04672	Intestinal immune network for IgA production	1/1221	37/7206	0.0145278757041
ko03410	Base excision repair	1/1221	38/7206	0.0148776720521
ko05131	Shigellosis	6/1221	82/7206	0.0170986118003
ko04115	p53 signaling pathway	5/1221	74/7206	0.0182193136556
ko04658	Th1 and Th2 cell differentiation	8/1221	96/7206	0.0198189770414
ko05231	Choline metabolism in cancer	33/1221	134/7206	0.0200393534493
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1221	14/7206	0.0205057574951
ko04923	Regulation of lipolysis in adipocytes	21/1221	77/7206	0.0210728918036
ko00860	Porphyrin and chlorophyll metabolism	1/1221	34/7206	0.0217933034241
ko05222	Small cell lung cancer	7/1221	89/7206	0.0218095228662
ko04973	Carbohydrate digestion and absorption	13/1221	42/7206	0.0220395250973
ko04214	Apoptosis - fly	5/1221	72/7206	0.0254140146807
ko00071	Fatty acid degradation	2/1221	45/7206	0.0257660524324
ko00590	Arachidonic acid metabolism	3/1221	52/7206	0.0259518307417
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1221	182/7206	0.0277249551378
ko04916	Melanogenesis	34/1221	142/7206	0.0311797728971
ko05166	HTLV-I infection	36/1221	292/7206	0.0314130439817
ko00562	Inositol phosphate metabolism	23/1221	89/7206	0.0319357215077
ko04210	Apoptosis	20/1221	180/7206	0.0343325210426
ko03015	mRNA surveillance pathway	8/1221	93/7206	0.0354906323314
ko04918	Thyroid hormone synthesis	22/1221	86/7206	0.0415795970638
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1221	100/7206	0.0426492802253
ko04146	Peroxisome	8/1221	89/7206	0.0457691116122
ko05320	Autoimmune thyroid disease	1/1221	29/7206	0.0484908530525
ko04950	Maturity onset diabetes of the young	1/1221	29/7206	0.0484908530525
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1221	92/7206	0.048874761517
ko05321	Inflammatory bowel disease (IBD)	4/1221	56/7206	0.0490007456879