ko pathway ratio_in_study ratio_in_pop p_value ko05032 Morphine addiction 12/177 110/7206 1.43830105405e-05 ko04724 Glutamatergic synapse 14/177 152/7206 1.96979587941e-05 ko04072 Phospholipase D signaling pathway 15/177 197/7206 9.26257497066e-05 ko04010 MAPK signaling pathway 20/177 321/7206 0.000108464576953 ko04713 Circadian entrainment 12/177 136/7206 0.000119087345643 ko04211 Longevity regulating pathway 11/177 123/7206 0.00020385437615 ko04727 GABAergic synapse 10/177 110/7206 0.000348051093589 ko04915 Estrogen signaling pathway 11/177 131/7206 0.000354103260671 ko04725 Cholinergic synapse 12/177 160/7206 0.000542199248113 ko01521 EGFR tyrosine kinase inhibitor resistance 9/177 106/7206 0.0011271986208 ko04213 Longevity regulating pathway - multiple species 8/177 86/7206 0.00117297982876 ko00562 Inositol phosphate metabolism 8/177 89/7206 0.00146694336085 ko05231 Choline metabolism in cancer 10/177 134/7206 0.00163097637346 ko04070 Phosphatidylinositol signaling system 9/177 112/7206 0.00166334192147 ko04911 Insulin secretion 9/177 117/7206 0.00225189349991 ko04923 Regulation of lipolysis in adipocytes 7/177 77/7206 0.00270917898747 ko00515 Mannose type O-glycan biosynthesis 4/177 25/7206 0.00297220179694 ko04912 GnRH signaling pathway 9/177 122/7206 0.00299563276827 ko01522 Endocrine resistance 9/177 124/7206 0.00334253238801 ko04742 Taste transduction 6/177 61/7206 0.00365815678064 ko04371 Apelin signaling pathway 11/177 177/7206 0.00410814118577 ko04925 Aldosterone synthesis and secretion 8/177 105/7206 0.00415688066093 ko04913 Ovarian steroidogenesis 6/177 63/7206 0.00429967671323 ko04261 Adrenergic signaling in cardiomyocytes 12/177 205/7206 0.00448507104874 ko04728 Dopaminergic synapse 11/177 185/7206 0.0057228251406 ko04144 Endocytosis 17/177 342/7206 0.00592222681164 ko05414 Dilated cardiomyopathy 8/177 112/7206 0.00613450152169 ko04020 Calcium signaling pathway 14/177 265/7206 0.00672526517808 ko04970 Salivary secretion 7/177 95/7206 0.00861861506399 ko05030 Cocaine addiction 6/177 73/7206 0.00881191182943 ko04014 Ras signaling pathway 14/177 279/7206 0.00940855809741 ko04723 Retrograde endocannabinoid signaling 10/177 175/7206 0.0108084492544 ko04022 cGMP-PKG signaling pathway 12/177 216/7206 0.0110435035943 ko04914 Progesterone-mediated oocyte maturation 7/177 104/7206 0.0137989074025 ko04012 ErbB signaling pathway 7/177 109/7206 0.0174892879765 ko00750 Vitamin B6 metabolism 2/177 9/7206 0.0192805568355 ko05031 Amphetamine addiction 6/177 91/7206 0.0240930228509 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 3/177 26/7206 0.0250216040284 ko04024 cAMP signaling pathway 13/177 279/7206 0.0266018812626 ko04360 Axon guidance 11/177 233/7206 0.0309143992135 ko04062 Chemokine signaling pathway 10/177 201/7206 0.0322766145245 ko00564 Glycerophospholipid metabolism 6/177 99/7206 0.0345628545806 ko04540 Gap junction 7/177 128/7206 0.0378190515036 ko04910 Insulin signaling pathway 9/177 172/7206 0.03869432449 ko04711 Circadian rhythm - fly 2/177 13/7206 0.0391769205796 ko04011 MAPK signaling pathway - yeast 4/177 53/7206 0.0405493442042 ko04930 Type II diabetes mellitus 4/177 54/7206 0.042984634489 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5/177 79/7206 0.0443249573447 ko05214 Glioma 5/177 79/7206 0.0443249573447 ko04740 Olfactory transduction 5/177 80/7206 0.0463784653581 ko04015 Rap1 signaling pathway 12/177 278/7206 0.0478124716675 ko05033 Nicotine addiction 4/177 56/7206 0.0480977544209