ko pathway ratio_in_study ratio_in_pop p_value ko05031 Amphetamine addiction 13/151 91/7206 4.20367337528e-08 ko04724 Glutamatergic synapse 16/151 152/7206 9.25387562965e-08 ko04720 Long-term potentiation 13/151 99/7206 1.17429109155e-07 ko04911 Insulin secretion 14/151 117/7206 1.23581942266e-07 ko04725 Cholinergic synapse 16/151 160/7206 1.89958935424e-07 ko04713 Circadian entrainment 14/151 136/7206 8.11164205915e-07 ko04728 Dopaminergic synapse 15/151 185/7206 6.68150606065e-06 ko04020 Calcium signaling pathway 18/151 265/7206 9.44878600469e-06 ko04310 Wnt signaling pathway 14/151 181/7206 2.35237474441e-05 ko04360 Axon guidance 16/151 233/7206 2.67629571434e-05 ko04921 Oxytocin signaling pathway 15/151 209/7206 2.89298227696e-05 ko04916 Melanogenesis 12/151 142/7206 3.86912091191e-05 ko04924 Renin secretion 9/151 86/7206 7.13347905591e-05 ko04261 Adrenergic signaling in cardiomyocytes 14/151 205/7206 9.27763092427e-05 ko04745 Phototransduction - fly 6/151 38/7206 0.000121599257066 ko04726 Serotonergic synapse 11/151 137/7206 0.000130421587601 ko04971 Gastric acid secretion 9/151 98/7206 0.000197179406192 ko04912 GnRH signaling pathway 10/151 122/7206 0.000224109058923 ko04925 Aldosterone synthesis and secretion 9/151 105/7206 0.000332482674763 ko04024 cAMP signaling pathway 15/151 279/7206 0.000710898433245 ko04010 MAPK signaling pathway 16/151 321/7206 0.00106661518594 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/151 79/7206 0.0012667697747 ko04740 Olfactory transduction 7/151 80/7206 0.0013642917906 ko04922 Glucagon signaling pathway 9/151 128/7206 0.00140253823493 ko04540 Gap junction 9/151 128/7206 0.00140253823493 ko04727 GABAergic synapse 8/151 110/7206 0.00208166721531 ko05032 Morphine addiction 8/151 110/7206 0.00208166721531 ko04750 Inflammatory mediator regulation of TRP channels 8/151 122/7206 0.00396404933293 ko05014 Amyotrophic lateral sclerosis (ALS) 6/151 74/7206 0.00439819449579 ko04626 Plant-pathogen interaction 3/151 18/7206 0.00584185876308 ko04012 ErbB signaling pathway 7/151 109/7206 0.00774090421999 ko04114 Oocyte meiosis 8/151 139/7206 0.0086101582181 ko04742 Taste transduction 5/151 61/7206 0.00876392643101 ko05414 Dilated cardiomyopathy 7/151 112/7206 0.00893681956428 ko04918 Thyroid hormone synthesis 6/151 86/7206 0.00909972026813 ko04151 PI3K-Akt signaling pathway 16/151 390/7206 0.00942164741831 ko04723 Retrograde endocannabinoid signaling 9/151 175/7206 0.0110497521011 ko04970 Salivary secretion 6/151 95/7206 0.0144404768472 ko04270 Vascular smooth muscle contraction 8/151 154/7206 0.0153617634659 ko04214 Apoptosis - fly 5/151 72/7206 0.0171745287439 ko05030 Cocaine addiction 5/151 73/7206 0.0181350713419 ko04514 Cell adhesion molecules (CAMs) 7/151 130/7206 0.0191203516989 ko04915 Estrogen signaling pathway 7/151 131/7206 0.019856280878 ko05200 Pathways in cancer 18/151 492/7206 0.0205814102142 ko00512 Mucin type O-glycan biosynthesis 3/151 29/7206 0.0221255283036 ko04370 VEGF signaling pathway 5/151 77/7206 0.0223305500846 ko04512 ECM-receptor interaction 5/151 79/7206 0.0246462311515 ko05214 Glioma 5/151 79/7206 0.0246462311515 ko05206 MicroRNAs in cancer 8/151 177/7206 0.0321774432892 ko05216 Thyroid cancer 3/151 34/7206 0.0335996471057 ko05210 Colorectal cancer 5/151 86/7206 0.0339447004179 ko04961 Endocrine and other factor-regulated calcium reabsorption 4/151 59/7206 0.0346500384828 ko04662 B cell receptor signaling pathway 5/151 88/7206 0.036952059918 ko05222 Small cell lung cancer 5/151 89/7206 0.0385153564652 ko04391 Hippo signaling pathway - fly 5/151 90/7206 0.0401186408645 ko00360 Phenylalanine metabolism 2/151 17/7206 0.0482939303499 ko04015 Rap1 signaling pathway 11/151 278/7206 0.0490775541363 ko04014 Ras signaling pathway 11/151 279/7206 0.0494612399153