ko pathway ratio_in_study ratio_in_pop p_value ko04725 Cholinergic synapse 18/280 160/7206 4.41164178566e-05 ko04060 Cytokine-cytokine receptor interaction 19/280 191/7206 0.000145911666269 ko04911 Insulin secretion 14/280 117/7206 0.000162316229523 ko04925 Aldosterone synthesis and secretion 13/280 105/7206 0.000196685333873 ko04710 Circadian rhythm 8/280 43/7206 0.000208298596901 ko04014 Ras signaling pathway 24/280 279/7206 0.000210956493195 ko04713 Circadian entrainment 14/280 136/7206 0.000774282946083 ko04724 Glutamatergic synapse 15/280 152/7206 0.000790438634418 ko04020 Calcium signaling pathway 22/280 265/7206 0.00087095424949 ko04711 Circadian rhythm - fly 4/280 13/7206 0.00120802548997 ko05031 Amphetamine addiction 10/280 91/7206 0.00265835456189 ko04728 Dopaminergic synapse 16/280 185/7206 0.00277287011834 ko04745 Phototransduction - fly 6/280 38/7206 0.00315494976482 ko04921 Oxytocin signaling pathway 17/280 209/7206 0.00329298336451 ko04015 Rap1 signaling pathway 21/280 278/7206 0.00365282716827 ko04912 GnRH signaling pathway 11/280 122/7206 0.00764970498154 ko04261 Adrenergic signaling in cardiomyocytes 16/280 205/7206 0.00850868269537 ko04022 cGMP-PKG signaling pathway 16/280 216/7206 0.0114335159103 ko04070 Phosphatidylinositol signaling system 10/280 112/7206 0.0114914132752 ko04072 Phospholipase D signaling pathway 15/280 197/7206 0.0129223502931 ko05230 Central carbon metabolism in cancer 8/280 81/7206 0.0129672859681 ko04971 Gastric acid secretion 9/280 98/7206 0.0135823620697 ko04360 Axon guidance 17/280 233/7206 0.0138976924464 ko04151 PI3K-Akt signaling pathway 25/280 390/7206 0.0142396581955 ko04720 Long-term potentiation 9/280 99/7206 0.0144495168503 ko04024 cAMP signaling pathway 19/280 279/7206 0.0164244329792 ko04924 Renin secretion 8/280 86/7206 0.0181327534463 ko05231 Choline metabolism in cancer 11/280 134/7206 0.0195992150326 ko04933 AGE-RAGE signaling pathway in diabetic complications 11/280 135/7206 0.0201946124994 ko04726 Serotonergic synapse 11/280 137/7206 0.0214990137045 ko03013 RNA transport 1/280 166/7206 0.0224639025031 ko04750 Inflammatory mediator regulation of TRP channels 10/280 122/7206 0.0276043556836 ko04970 Salivary secretion 8/280 95/7206 0.030888316189 ko05322 Systemic lupus erythematosus 1/280 151/7206 0.0313804711967 ko04922 Glucagon signaling pathway 10/280 128/7206 0.0328766319493 ko04215 Apoptosis - multiple species 5/280 47/7206 0.0346301220613 ko04740 Olfactory transduction 7/280 80/7206 0.0352392947804 ko04080 Neuroactive ligand-receptor interaction 25/280 423/7206 0.0365695546696 ko00350 Tyrosine metabolism 4/280 33/7206 0.0376564748736 ko04068 FoxO signaling pathway 12/280 167/7206 0.0387873190685 ko05212 Pancreatic cancer 7/280 83/7206 0.0418047326197 ko04120 Ubiquitin mediated proteolysis 1/280 138/7206 0.0449425820138 ko00100 Steroid biosynthesis 3/280 21/7206 0.0460054496583 ko03040 Spliceosome 1/280 145/7206 0.0463077730204 ko05210 Colorectal cancer 7/280 86/7206 0.0491178000807 ko04918 Thyroid hormone synthesis 7/280 86/7206 0.0491178000807