ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 12/810 20/7206 2.01216033231e-07 ko04060 Cytokine-cytokine receptor interaction 43/810 191/7206 6.59188881373e-06 ko03010 Ribosome 1/810 129/7206 6.73357386734e-06 ko03040 Spliceosome 2/810 145/7206 7.75716440274e-06 ko04137 Mitophagy - animal 23/810 82/7206 2.17060072753e-05 ko04146 Peroxisome 24/810 89/7206 2.96334164736e-05 ko04610 Complement and coagulation cascades 22/810 79/7206 3.68727764655e-05 ko04710 Circadian rhythm 15/810 43/7206 3.70410841236e-05 ko03013 RNA transport 4/810 166/7206 4.91456023028e-05 ko03320 PPAR signaling pathway 19/810 69/7206 0.000145774686592 ko01040 Biosynthesis of unsaturated fatty acids 10/810 25/7206 0.000204741666976 ko04110 Cell cycle 4/810 145/7206 0.000278145689955 ko04380 Osteoclast differentiation 29/810 134/7206 0.00044583606912 ko00051 Fructose and mannose metabolism 13/810 42/7206 0.000471309637022 ko05034 Alcoholism 11/810 238/7206 0.00050361243806 ko01212 Fatty acid metabolism 16/810 60/7206 0.000707660309645 ko00380 Tryptophan metabolism 14/810 50/7206 0.00089092457454 ko05203 Viral carcinogenesis 15/810 277/7206 0.000916156695374 ko04922 Glucagon signaling pathway 27/810 128/7206 0.00101420766353 ko00140 Steroid hormone biosynthesis 12/810 41/7206 0.00134291758461 ko04020 Calcium signaling pathway 47/810 265/7206 0.00139876853429 ko05150 Staphylococcus aureus infection 11/810 36/7206 0.0014349937307 ko04136 Autophagy - other 10/810 31/7206 0.00148240851282 ko00362 Benzoate degradation 4/810 6/7206 0.00197285462675 ko04068 FoxO signaling pathway 32/810 167/7206 0.00260776711636 ko04621 NOD-like receptor signaling pathway 30/810 157/7206 0.00307186434112 ko00071 Fatty acid degradation 12/810 45/7206 0.0032062842629 ko00592 alpha-Linolenic acid metabolism 7/810 19/7206 0.00329546179911 ko00620 Pyruvate metabolism 12/810 46/7206 0.00390461024022 ko04138 Autophagy - yeast 18/810 81/7206 0.00393983508138 ko05321 Inflammatory bowel disease (IBD) 14/810 56/7206 0.0041334007007 ko00983 Drug metabolism - other enzymes 11/810 42/7206 0.0054550322023 ko00982 Drug metabolism - cytochrome P450 10/810 37/7206 0.00624207983468 ko00360 Phenylalanine metabolism 6/810 17/7206 0.00822512462577 ko04022 cGMP-PKG signaling pathway 37/810 216/7206 0.00830444316307 ko04650 Natural killer cell mediated cytotoxicity 20/810 97/7206 0.00846060094224 ko00350 Tyrosine metabolism 9/810 33/7206 0.00873793038956 ko02010 ABC transporters 10/810 39/7206 0.00926573535014 ko04070 Phosphatidylinositol signaling system 22/810 112/7206 0.0093265864189 ko05323 Rheumatoid arthritis 18/810 89/7206 0.0109058310206 ko04111 Cell cycle - yeast 3/810 90/7206 0.0112827572742 ko03015 mRNA surveillance pathway 3/810 93/7206 0.0117908612169 ko00590 Arachidonic acid metabolism 12/810 52/7206 0.0130223928686 ko04064 NF-kappa B signaling pathway 19/810 96/7206 0.0133676892025 ko04390 Hippo signaling pathway 11/810 188/7206 0.013930135676 ko05340 Primary immunodeficiency 8/810 30/7206 0.0151218591773 ko04550 Signaling pathways regulating pluripotency of stem cells 9/810 165/7206 0.0169563957016 ko05322 Systemic lupus erythematosus 8/810 151/7206 0.018210841719 ko05204 Chemical carcinogenesis 11/810 48/7206 0.0186386093558 ko00950 Isoquinoline alkaloid biosynthesis 4/810 10/7206 0.0190870276297 ko05224 Breast cancer 10/810 174/7206 0.0201077557988 ko04113 Meiosis - yeast 2/810 70/7206 0.0210094400692 ko00330 Arginine and proline metabolism 13/810 61/7206 0.0221727274726 ko00830 Retinol metabolism 10/810 42/7206 0.0223305839513 ko05100 Bacterial invasion of epithelial cells 4/810 99/7206 0.0230861153111 ko00010 Glycolysis / Gluconeogenesis 15/810 74/7206 0.0238440138787 ko05152 Tuberculosis 31/810 187/7206 0.0251596252821 ko04921 Oxytocin signaling pathway 34/810 209/7206 0.0255832618488 ko04011 MAPK signaling pathway - yeast 1/810 53/7206 0.0265044468899 ko04640 Hematopoietic cell lineage 13/810 64/7206 0.0280793146356 ko04072 Phospholipase D signaling pathway 32/810 197/7206 0.0293679464643 ko05144 Malaria 10/810 45/7206 0.0297002622588 ko04672 Intestinal immune network for IgA production 9/810 37/7206 0.0307371234986 ko05145 Toxoplasmosis 22/810 126/7206 0.0321426658428 ko04745 Phototransduction - fly 9/810 38/7206 0.0328296281884 ko04270 Vascular smooth muscle contraction 26/810 154/7206 0.0376707591144 ko04620 Toll-like receptor signaling pathway 18/810 100/7206 0.0376939779378 ko00980 Metabolism of xenobiotics by cytochrome P450 9/810 40/7206 0.0387743088039 ko04350 TGF-beta signaling pathway 5/810 103/7206 0.039617789289 ko04120 Ubiquitin mediated proteolysis 8/810 138/7206 0.040496685184 ko04925 Aldosterone synthesis and secretion 19/810 105/7206 0.0408585102159 ko04659 Th17 cell differentiation 19/810 106/7206 0.0418475979331 ko04391 Hippo signaling pathway - fly 4/810 90/7206 0.0419803682439 ko04144 Endocytosis 27/810 342/7206 0.0436444357724 ko04614 Renin-angiotensin system 5/810 18/7206 0.0437087120719 ko01200 Carbon metabolism 22/810 128/7206 0.0462189973443 ko00640 Propanoate metabolism 8/810 34/7206 0.0485912076339 ko00680 Methane metabolism 8/810 34/7206 0.0485912076339 ko04711 Circadian rhythm - fly 4/810 13/7206 0.0494796321574