ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 51/355 145/7206 4.87336111381e-31 ko03460 Fanconi anemia pathway 26/355 51/7206 3.32677376633e-21 ko04111 Cell cycle - yeast 32/355 90/7206 6.58551692723e-20 ko03040 Spliceosome 39/355 145/7206 4.11984970342e-19 ko03030 DNA replication 21/355 38/7206 2.61699343995e-18 ko03440 Homologous recombination 21/355 41/7206 2.1354251772e-17 ko04113 Meiosis - yeast 22/355 70/7206 8.88481691272e-13 ko03430 Mismatch repair 12/355 22/7206 7.04840823675e-11 ko04080 Neuroactive ligand-receptor interaction 1/355 423/7206 1.03528972308e-08 ko03410 Base excision repair 13/355 38/7206 1.42934248204e-08 ko03420 Nucleotide excision repair 13/355 46/7206 1.87434710091e-07 ko03008 Ribosome biogenesis in eukaryotes 16/355 79/7206 1.0779639132e-06 ko00240 Pyrimidine metabolism 19/355 110/7206 1.39677870312e-06 ko03013 RNA transport 24/355 166/7206 1.67348012879e-06 ko03018 RNA degradation 15/355 84/7206 1.20126534103e-05 ko04218 Cellular senescence 23/355 177/7206 1.70327733673e-05 ko04020 Calcium signaling pathway 1/355 265/7206 3.30226534724e-05 ko04115 p53 signaling pathway 13/355 74/7206 5.49162124815e-05 ko04114 Oocyte meiosis 18/355 139/7206 0.000147706521252 ko05166 HTLV-I infection 29/355 292/7206 0.00026388525136 ko05322 Systemic lupus erythematosus 18/355 151/7206 0.00041953762113 ko05203 Viral carcinogenesis 27/355 277/7206 0.000575894286762 ko05010 Alzheimer's disease 1/355 202/7206 0.000740200876584 ko04014 Ras signaling pathway 3/355 279/7206 0.000945709261141 ko04060 Cytokine-cytokine receptor interaction 1/355 191/7206 0.00106613012911 ko03015 mRNA surveillance pathway 12/355 93/7206 0.00191407186836 ko04022 cGMP-PKG signaling pathway 2/355 216/7206 0.00212613841637 ko04723 Retrograde endocannabinoid signaling 1/355 175/7206 0.00227742421306 ko04024 cAMP signaling pathway 4/355 279/7206 0.0027904943769 ko04261 Adrenergic signaling in cardiomyocytes 2/355 205/7206 0.00453673710911 ko04914 Progesterone-mediated oocyte maturation 12/355 104/7206 0.00489106667881 ko04142 Lysosome 1/355 151/7206 0.00702982840661 ko04724 Glutamatergic synapse 1/355 152/7206 0.007056321362 ko05012 Parkinson's disease 1/355 155/7206 0.00725312332385 ko05212 Pancreatic cancer 10/355 83/7206 0.00728801198121 ko04010 MAPK signaling pathway 6/355 321/7206 0.00761582748749 ko04728 Dopaminergic synapse 2/355 185/7206 0.00883775454537 ko05152 Tuberculosis 2/355 187/7206 0.00898699376163 ko04144 Endocytosis 7/355 342/7206 0.00972644367134 ko04151 PI3K-Akt signaling pathway 9/355 390/7206 0.0110532484245 ko05222 Small cell lung cancer 10/355 89/7206 0.0117516702389 ko05168 Herpes simplex infection 17/355 182/7206 0.0132848146819 ko04510 Focal adhesion 4/355 240/7206 0.0140993241371 ko04380 Osteoclast differentiation 1/355 134/7206 0.014752811458 ko04713 Circadian entrainment 1/355 136/7206 0.0148439174598 ko00230 Purine metabolism 17/355 194/7206 0.0179203875945 ko05145 Toxoplasmosis 1/355 126/7206 0.021323041201 ko00190 Oxidative phosphorylation 1/355 127/7206 0.021370509801 ko01200 Carbon metabolism 1/355 128/7206 0.0214707976859 ko05216 Thyroid cancer 5/355 34/7206 0.0241847147611 ko04725 Cholinergic synapse 2/355 160/7206 0.0248406573314 ko04140 Autophagy - animal 2/355 164/7206 0.0257790228383 ko05219 Bladder cancer 6/355 48/7206 0.0293094700374 ko04750 Inflammatory mediator regulation of TRP channels 1/355 122/7206 0.0315228284423 ko04330 Notch signaling pathway 7/355 62/7206 0.0317899337524 ko05034 Alcoholism 19/355 238/7206 0.0326040782725 ko04139 Mitophagy - yeast 5/355 37/7206 0.0336263629349 ko05206 MicroRNAs in cancer 15/355 177/7206 0.0341666702348 ko04921 Oxytocin signaling pathway 4/355 209/7206 0.034934514927 ko04270 Vascular smooth muscle contraction 2/355 154/7206 0.0354602045077 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/355 182/7206 0.0357263734582 ko04012 ErbB signaling pathway 1/355 109/7206 0.044233215789 ko04727 GABAergic synapse 1/355 110/7206 0.0442725520719 ko05032 Morphine addiction 1/355 110/7206 0.0442725520719 ko04972 Pancreatic secretion 1/355 111/7206 0.0444113755876 ko04070 Phosphatidylinositol signaling system 1/355 112/7206 0.0446492697459 ko05217 Basal cell carcinoma 7/355 68/7206 0.0489190291908 ko04371 Apelin signaling pathway 3/355 177/7206 0.0499764257105