ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1105	423/7206	6.69596519738e-45
ko04724	Glutamatergic synapse	89/1105	152/7206	4.00034647765e-35
ko05033	Nicotine addiction	50/1105	56/7206	9.40101496262e-35
ko05032	Morphine addiction	68/1105	110/7206	4.81989520152e-29
ko04727	GABAergic synapse	65/1105	110/7206	3.42307626581e-26
ko04713	Circadian entrainment	72/1105	136/7206	7.41732054784e-25
ko04728	Dopaminergic synapse	81/1105	185/7206	6.46698108975e-21
ko04725	Cholinergic synapse	72/1105	160/7206	1.570433613e-19
ko04723	Retrograde endocannabinoid signaling	76/1105	175/7206	1.98570448363e-19
ko04024	cAMP signaling pathway	96/1105	279/7206	6.71755269925e-16
ko04721	Synaptic vesicle cycle	43/1105	80/7206	1.24846302659e-15
ko04911	Insulin secretion	54/1105	117/7206	1.60495486949e-15
ko04020	Calcium signaling pathway	92/1105	265/7206	1.97870758532e-15
ko04742	Taste transduction	35/1105	61/7206	4.11160801464e-14
ko04921	Oxytocin signaling pathway	72/1105	209/7206	3.34633352328e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1105	205/7206	3.86386823744e-12
ko04744	Phototransduction	24/1105	36/7206	4.44960835661e-12
ko04726	Serotonergic synapse	53/1105	137/7206	1.65180273336e-11
ko05031	Amphetamine addiction	40/1105	91/7206	5.258644942e-11
ko04720	Long-term potentiation	40/1105	99/7206	1.15891985151e-09
ko03040	Spliceosome	1/1105	145/7206	1.36792289582e-09
ko05030	Cocaine addiction	31/1105	73/7206	2.1526575277e-08
ko04925	Aldosterone synthesis and secretion	39/1105	105/7206	3.07472396508e-08
ko04970	Salivary secretion	36/1105	95/7206	5.74449546556e-08
ko04010	MAPK signaling pathway	86/1105	321/7206	7.43518416818e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1105	74/7206	4.89526320008e-07
ko04360	Axon guidance	64/1105	233/7206	1.72328210128e-06
ko04070	Phosphatidylinositol signaling system	37/1105	112/7206	2.16971517624e-06
ko05203	Viral carcinogenesis	17/1105	277/7206	2.35699695545e-06
ko05322	Systemic lupus erythematosus	5/1105	151/7206	3.0868925253e-06
ko04072	Phospholipase D signaling pathway	55/1105	197/7206	4.63654894943e-06
ko04971	Gastric acid secretion	33/1105	98/7206	5.87945312123e-06
ko04972	Pancreatic secretion	36/1105	111/7206	6.3483966847e-06
ko03013	RNA transport	7/1105	166/7206	9.10860128278e-06
ko05168	Herpes simplex infection	9/1105	182/7206	1.49280291115e-05
ko04022	cGMP-PKG signaling pathway	57/1105	216/7206	1.99977955017e-05
ko05164	Influenza A	8/1105	167/7206	2.78626459578e-05
ko04060	Cytokine-cytokine receptor interaction	11/1105	191/7206	5.92897764449e-05
ko04621	NOD-like receptor signaling pathway	8/1105	157/7206	7.62914638207e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1105	79/7206	9.88576702489e-05
ko04514	Cell adhesion molecules (CAMs)	37/1105	130/7206	0.000110504443256
ko05414	Dilated cardiomyopathy	33/1105	112/7206	0.00015822950033
ko05205	Proteoglycans in cancer	21/1105	271/7206	0.000199634289753
ko04740	Olfactory transduction	25/1105	80/7206	0.000269647444602
ko04260	Cardiac muscle contraction	29/1105	98/7206	0.000316718886383
ko04915	Estrogen signaling pathway	36/1105	131/7206	0.000318872143556
ko04141	Protein processing in endoplasmic reticulum	12/1105	184/7206	0.000373399445563
ko03008	Ribosome biogenesis in eukaryotes	2/1105	79/7206	0.000411346700637
ko04640	Hematopoietic cell lineage	1/1105	64/7206	0.000646961469104
ko04064	NF-kappa B signaling pathway	4/1105	96/7206	0.000884066970882
ko04110	Cell cycle	9/1105	145/7206	0.00101930783621
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1105	59/7206	0.00149527502176
ko05162	Measles	7/1105	120/7206	0.00197941753452
ko04612	Antigen processing and presentation	3/1105	77/7206	0.00229208088096
ko05110	Vibrio cholerae infection	19/1105	63/7206	0.00244252164497
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1105	14/7206	0.0024898309366
ko04014	Ras signaling pathway	61/1105	279/7206	0.00294682895818
ko05169	Epstein-Barr virus infection	17/1105	206/7206	0.00309100753278
ko05140	Leishmaniasis	3/1105	75/7206	0.00330363215295
ko04966	Collecting duct acid secretion	10/1105	26/7206	0.00349724711623
ko04923	Regulation of lipolysis in adipocytes	22/1105	77/7206	0.00353832128518
ko04730	Long-term depression	22/1105	78/7206	0.00377838520312
ko04540	Gap junction	32/1105	128/7206	0.00407019521853
ko04976	Bile secretion	22/1105	80/7206	0.00452745301738
ko04745	Phototransduction - fly	13/1105	38/7206	0.00484680442761
ko05161	Hepatitis B	14/1105	173/7206	0.00536122603367
ko04924	Renin secretion	23/1105	86/7206	0.00604373919218
ko04510	Focal adhesion	22/1105	240/7206	0.0060481133396
ko04210	Apoptosis	15/1105	180/7206	0.00629065811983
ko03320	PPAR signaling pathway	3/1105	69/7206	0.00675371622519
ko05016	Huntington's disease	19/1105	215/7206	0.00682540608545
ko03420	Nucleotide excision repair	1/1105	46/7206	0.00693817041068
ko00240	Pyrimidine metabolism	7/1105	110/7206	0.00704616572205
ko00260	Glycine, serine and threonine metabolism	1/1105	48/7206	0.00735477155042
ko04217	Necroptosis	15/1105	178/7206	0.00813957451864
ko05145	Toxoplasmosis	9/1105	126/7206	0.00830747183223
ko05321	Inflammatory bowel disease (IBD)	2/1105	56/7206	0.00867672247305
ko00513	Various types of N-glycan biosynthesis	13/1105	42/7206	0.00895968404679
ko05133	Pertussis	5/1105	87/7206	0.0101279530855
ko03022	Basal transcription factors	1/1105	44/7206	0.0104233602495
ko04371	Apelin signaling pathway	40/1105	177/7206	0.0107604446807
ko00071	Fatty acid degradation	1/1105	45/7206	0.0107864582119
ko00562	Inositol phosphate metabolism	23/1105	89/7206	0.0108169969736
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1105	182/7206	0.0119927871463
ko00480	Glutathione metabolism	2/1105	55/7206	0.0129412523191
ko03018	RNA degradation	5/1105	84/7206	0.0139126269541
ko04115	p53 signaling pathway	4/1105	74/7206	0.0140669646894
ko04918	Thyroid hormone synthesis	22/1105	86/7206	0.0147439634758
ko04750	Inflammatory mediator regulation of TRP channels	29/1105	122/7206	0.0151842238318
ko00140	Steroid hormone biosynthesis	1/1105	41/7206	0.0154672365288
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1105	15/7206	0.0185320152522
ko00330	Arginine and proline metabolism	3/1105	61/7206	0.0193901812246
ko04622	RIG-I-like receptor signaling pathway	3/1105	62/7206	0.0197174982464
ko03410	Base excision repair	1/1105	38/7206	0.0229695048666
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1105	100/7206	0.0240519830886
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1105	40/7206	0.0243487053962
ko04657	IL-17 signaling pathway	6/1105	87/7206	0.0244024677223
ko04146	Peroxisome	6/1105	89/7206	0.0249745854192
ko05231	Choline metabolism in cancer	30/1105	134/7206	0.0286479649914
ko04120	Ubiquitin mediated proteolysis	12/1105	138/7206	0.0308715017564
ko04658	Th1 and Th2 cell differentiation	7/1105	96/7206	0.0309784354064
ko04710	Circadian rhythm	12/1105	43/7206	0.0314264326496
ko00512	Mucin type O-glycan biosynthesis	9/1105	29/7206	0.0331607475763
ko04964	Proximal tubule bicarbonate reclamation	9/1105	29/7206	0.0331607475763
ko00982	Drug metabolism - cytochrome P450	1/1105	37/7206	0.035553987519
ko04930	Type II diabetes mellitus	14/1105	54/7206	0.0368423277239
ko04711	Circadian rhythm - fly	5/1105	13/7206	0.0370788283998
ko04670	Leukocyte transendothelial migration	14/1105	151/7206	0.0391347874321
ko04912	GnRH signaling pathway	27/1105	122/7206	0.0420619966691
ko05034	Alcoholism	48/1105	238/7206	0.0435613104155
ko00515	Mannose type O-glycan biosynthesis	8/1105	25/7206	0.0439612555622
ko05131	Shigellosis	6/1105	82/7206	0.0440559209756
ko00510	N-Glycan biosynthesis	13/1105	50/7206	0.0467393183411
ko04214	Apoptosis - fly	5/1105	72/7206	0.0477478921721
ko04140	Autophagy - animal	16/1105	164/7206	0.0478262461563
ko00310	Lysine degradation	5/1105	73/7206	0.0482643801867
ko04620	Toll-like receptor signaling pathway	8/1105	100/7206	0.0487455486184