ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	175/1079	423/7206	1.98272914124e-42
ko04724	Glutamatergic synapse	86/1079	152/7206	3.28063553701e-33
ko05033	Nicotine addiction	46/1079	56/7206	3.93762930863e-29
ko05032	Morphine addiction	64/1079	110/7206	7.1351291386e-26
ko04721	Synaptic vesicle cycle	52/1079	80/7206	1.86463662422e-24
ko04713	Circadian entrainment	70/1079	136/7206	7.17270421502e-24
ko04727	GABAergic synapse	61/1079	110/7206	3.5036476516e-23
ko04728	Dopaminergic synapse	81/1079	185/7206	1.35218709651e-21
ko04725	Cholinergic synapse	74/1079	160/7206	1.49991605525e-21
ko04723	Retrograde endocannabinoid signaling	74/1079	175/7206	9.51126394374e-19
ko04024	cAMP signaling pathway	95/1079	279/7206	5.82359469493e-16
ko04921	Oxytocin signaling pathway	77/1079	209/7206	3.2624485685e-15
ko04020	Calcium signaling pathway	90/1079	265/7206	4.71517695792e-15
ko04911	Insulin secretion	52/1079	117/7206	1.36386220056e-14
ko04726	Serotonergic synapse	57/1079	137/7206	2.48773903897e-14
ko04742	Taste transduction	34/1079	61/7206	1.49918042852e-13
ko04720	Long-term potentiation	43/1079	99/7206	7.11155840628e-12
ko05031	Amphetamine addiction	40/1079	91/7206	2.45969164221e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1079	205/7206	1.0419392239e-10
ko04744	Phototransduction	22/1079	36/7206	2.72854727036e-10
ko03040	Spliceosome	1/1079	145/7206	2.18277558061e-09
ko04970	Salivary secretion	37/1079	95/7206	8.25501293105e-09
ko05168	Herpes simplex infection	5/1079	182/7206	7.12327042074e-08
ko04925	Aldosterone synthesis and secretion	37/1079	105/7206	2.13454823878e-07
ko04971	Gastric acid secretion	35/1079	98/7206	3.74266132952e-07
ko04966	Collecting duct acid secretion	15/1079	26/7206	5.89425526495e-07
ko05203	Viral carcinogenesis	15/1079	277/7206	7.07263391482e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1079	74/7206	1.08582563563e-06
ko03013	RNA transport	6/1079	166/7206	2.6574113588e-06
ko05030	Cocaine addiction	27/1079	73/7206	2.82241186213e-06
ko04360	Axon guidance	62/1079	233/7206	3.50786887414e-06
ko04010	MAPK signaling pathway	79/1079	321/7206	4.08889323391e-06
ko04022	cGMP-PKG signaling pathway	58/1079	216/7206	4.10932400517e-06
ko04514	Cell adhesion molecules (CAMs)	40/1079	130/7206	4.54614119235e-06
ko04540	Gap junction	39/1079	128/7206	7.31694927819e-06
ko04740	Olfactory transduction	28/1079	80/7206	8.60193291148e-06
ko04924	Renin secretion	29/1079	86/7206	1.10352456133e-05
ko04621	NOD-like receptor signaling pathway	6/1079	157/7206	1.18820558214e-05
ko05164	Influenza A	7/1079	167/7206	1.33869418229e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1079	79/7206	1.80814878829e-05
ko04141	Protein processing in endoplasmic reticulum	9/1079	184/7206	2.1832598572e-05
ko04972	Pancreatic secretion	34/1079	111/7206	2.21377684065e-05
ko04120	Ubiquitin mediated proteolysis	5/1079	138/7206	2.96125963845e-05
ko04060	Cytokine-cytokine receptor interaction	10/1079	191/7206	3.14959297089e-05
ko04730	Long-term depression	26/1079	78/7206	3.95762931585e-05
ko04745	Phototransduction - fly	16/1079	38/7206	4.87086378949e-05
ko05322	Systemic lupus erythematosus	7/1079	151/7206	7.36998463829e-05
ko05414	Dilated cardiomyopathy	33/1079	112/7206	7.7746225117e-05
ko05110	Vibrio cholerae infection	22/1079	63/7206	9.97427565149e-05
ko04110	Cell cycle	7/1079	145/7206	0.000145793839677
ko04260	Cardiac muscle contraction	29/1079	98/7206	0.000172776282423
ko04064	NF-kappa B signaling pathway	3/1079	96/7206	0.000253726748113
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1079	14/7206	0.000318227208795
ko04070	Phosphatidylinositol signaling system	31/1079	112/7206	0.000437442407709
ko05169	Epstein-Barr virus infection	14/1079	206/7206	0.000466893932073
ko04750	Inflammatory mediator regulation of TRP channels	33/1079	122/7206	0.000467744990155
ko04014	Ras signaling pathway	63/1079	279/7206	0.000576043937349
ko04612	Antigen processing and presentation	2/1079	77/7206	0.000612324787314
ko04610	Complement and coagulation cascades	2/1079	79/7206	0.000646754663349
ko03008	Ribosome biogenesis in eukaryotes	2/1079	79/7206	0.000646754663349
ko05205	Proteoglycans in cancer	22/1079	271/7206	0.000688040681832
ko05140	Leishmaniasis	2/1079	75/7206	0.00090820775676
ko05162	Measles	6/1079	120/7206	0.00107167022188
ko04915	Estrogen signaling pathway	34/1079	131/7206	0.00112929891452
ko04976	Bile secretion	23/1079	80/7206	0.00136355160173
ko04072	Phospholipase D signaling pathway	46/1079	197/7206	0.00158303060452
ko04964	Proximal tubule bicarbonate reclamation	11/1079	29/7206	0.00207486877427
ko00480	Glutathione metabolism	1/1079	55/7206	0.00211225153639
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1079	59/7206	0.00257620198972
ko04146	Peroxisome	4/1079	89/7206	0.00259427001949
ko04626	Plant-pathogen interaction	8/1079	18/7206	0.00265252107759
ko05161	Hepatitis B	13/1079	173/7206	0.00349783977151
ko04371	Apelin signaling pathway	41/1079	177/7206	0.00371245050163
ko00590	Arachidonic acid metabolism	1/1079	52/7206	0.00504532143314
ko04923	Regulation of lipolysis in adipocytes	21/1079	77/7206	0.0054695556439
ko04930	Type II diabetes mellitus	16/1079	54/7206	0.00600443455519
ko00330	Arginine and proline metabolism	2/1079	61/7206	0.00608826758156
ko04214	Apoptosis - fly	3/1079	72/7206	0.007000817254
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1079	100/7206	0.00712433801041
ko00240	Pyrimidine metabolism	7/1079	110/7206	0.00974460023886
ko03022	Basal transcription factors	1/1079	44/7206	0.010535539131
ko05144	Malaria	1/1079	45/7206	0.0105695351556
ko00071	Fatty acid degradation	1/1079	45/7206	0.0105695351556
ko03420	Nucleotide excision repair	1/1079	46/7206	0.0109096517447
ko05145	Toxoplasmosis	9/1079	126/7206	0.0111856756508
ko05166	HTLV-I infection	29/1079	292/7206	0.0119178907616
ko05321	Inflammatory bowel disease (IBD)	2/1079	56/7206	0.0129946777746
ko01524	Platinum drug resistance	4/1079	76/7206	0.0143053329938
ko04657	IL-17 signaling pathway	5/1079	87/7206	0.0143979649542
ko05131	Shigellosis	5/1079	82/7206	0.0191944288172
ko00280	Valine, leucine and isoleucine degradation	2/1079	54/7206	0.0193147010174
ko04668	TNF signaling pathway	9/1079	120/7206	0.0194775037711
ko04210	Apoptosis	16/1079	180/7206	0.0195047839373
ko04622	RIG-I-like receptor signaling pathway	3/1079	62/7206	0.019604208353
ko00310	Lysine degradation	4/1079	73/7206	0.0198424292834
ko04912	GnRH signaling pathway	28/1079	122/7206	0.0202415700541
ko04062	Chemokine signaling pathway	42/1079	201/7206	0.0208513374457
ko04114	Oocyte meiosis	31/1079	139/7206	0.0216792366351
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1079	40/7206	0.0236632923075
ko00140	Steroid hormone biosynthesis	1/1079	41/7206	0.0246958732711
ko04217	Necroptosis	16/1079	178/7206	0.0248182476167
ko04015	Rap1 signaling pathway	55/1079	278/7206	0.0256264056902
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1079	92/7206	0.0258633381588
ko04510	Focal adhesion	24/1079	240/7206	0.0270167920717
ko00512	Mucin type O-glycan biosynthesis	9/1079	29/7206	0.030841101162
ko05418	Fluid shear stress and atherosclerosis	16/1079	173/7206	0.0308445082656
ko05133	Pertussis	6/1079	87/7206	0.0332875691039
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1079	182/7206	0.0345578912204
ko00982	Drug metabolism - cytochrome P450	1/1079	37/7206	0.0348532622204
ko03410	Base excision repair	1/1079	38/7206	0.0361171198403
ko04350	TGF-beta signaling pathway	8/1079	103/7206	0.0367481552679
ko00260	Glycine, serine and threonine metabolism	2/1079	48/7206	0.0392908025505
ko05034	Alcoholism	47/1079	238/7206	0.0417106048839
ko04916	Melanogenesis	30/1079	142/7206	0.0432033482186
ko03018	RNA degradation	6/1079	84/7206	0.0444859908214
ko04115	p53 signaling pathway	5/1079	74/7206	0.0482753727245
ko04973	Carbohydrate digestion and absorption	11/1079	42/7206	0.0499682894999