ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/1076	423/7206	1.2386330563e-40
ko04724	Glutamatergic synapse	86/1076	152/7206	2.6395394247e-33
ko05032	Morphine addiction	66/1076	110/7206	8.01484128033e-28
ko05033	Nicotine addiction	45/1076	56/7206	8.65683037412e-28
ko04727	GABAergic synapse	63/1076	110/7206	4.99084470445e-25
ko04713	Circadian entrainment	69/1076	136/7206	3.83012937052e-23
ko04721	Synaptic vesicle cycle	50/1076	80/7206	1.77801185521e-22
ko04728	Dopaminergic synapse	81/1076	185/7206	1.12503251916e-21
ko04725	Cholinergic synapse	73/1076	160/7206	6.51441503294e-21
ko04723	Retrograde endocannabinoid signaling	77/1076	175/7206	8.24068086957e-21
ko04911	Insulin secretion	54/1076	117/7206	4.93280070801e-16
ko04024	cAMP signaling pathway	95/1076	279/7206	5.44531496668e-16
ko04020	Calcium signaling pathway	87/1076	265/7206	9.45914173359e-14
ko04921	Oxytocin signaling pathway	74/1076	209/7206	1.21883907932e-13
ko04742	Taste transduction	34/1076	61/7206	1.3792213381e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1076	205/7206	4.40713951324e-12
ko04726	Serotonergic synapse	53/1076	137/7206	5.75248199234e-12
ko05031	Amphetamine addiction	39/1076	91/7206	1.02684112004e-10
ko04720	Long-term potentiation	40/1076	99/7206	5.14223740737e-10
ko04970	Salivary secretion	38/1076	95/7206	1.96601805216e-09
ko03040	Spliceosome	1/1076	145/7206	2.18713792352e-09
ko04744	Phototransduction	21/1076	36/7206	2.22579881387e-09
ko04360	Axon guidance	70/1076	233/7206	2.99737451278e-09
ko04925	Aldosterone synthesis and secretion	38/1076	105/7206	5.0010535545e-08
ko04971	Gastric acid secretion	36/1076	98/7206	7.24535875952e-08
ko05203	Viral carcinogenesis	14/1076	277/7206	1.80023444021e-07
ko03013	RNA transport	5/1076	166/7206	7.14384991587e-07
ko04540	Gap junction	40/1076	128/7206	2.17178220872e-06
ko04022	cGMP-PKG signaling pathway	59/1076	216/7206	2.27255999063e-06
ko05168	Herpes simplex infection	7/1076	182/7206	2.31240577384e-06
ko04060	Cytokine-cytokine receptor interaction	8/1076	191/7206	2.53365827519e-06
ko05164	Influenza A	6/1076	167/7206	2.6706568918e-06
ko05030	Cocaine addiction	27/1076	73/7206	2.67204079907e-06
ko05322	Systemic lupus erythematosus	5/1076	151/7206	4.5532469496e-06
ko04120	Ubiquitin mediated proteolysis	4/1076	138/7206	5.18074944114e-06
ko04740	Olfactory transduction	28/1076	80/7206	8.34338175967e-06
ko05414	Dilated cardiomyopathy	35/1076	112/7206	1.09724297354e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1076	79/7206	1.73929310618e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1076	74/7206	1.80100064212e-05
ko04972	Pancreatic secretion	34/1076	111/7206	2.11515850742e-05
ko04141	Protein processing in endoplasmic reticulum	9/1076	184/7206	2.17378011419e-05
ko04070	Phosphatidylinositol signaling system	34/1076	112/7206	2.50058052776e-05
ko04966	Collecting duct acid secretion	13/1076	26/7206	2.65688455091e-05
ko04010	MAPK signaling pathway	76/1076	321/7206	2.66007179204e-05
ko04514	Cell adhesion molecules (CAMs)	38/1076	130/7206	2.81541001324e-05
ko04621	NOD-like receptor signaling pathway	7/1076	157/7206	3.71605707544e-05
ko04745	Phototransduction - fly	16/1076	38/7206	4.70345594036e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1076	79/7206	8.41472918459e-05
ko04924	Renin secretion	27/1076	86/7206	9.47626343138e-05
ko04260	Cardiac muscle contraction	29/1076	98/7206	0.000166106515778
ko05205	Proteoglycans in cancer	20/1076	271/7206	0.000169837825732
ko04976	Bile secretion	25/1076	80/7206	0.000194178702681
ko04072	Phospholipase D signaling pathway	49/1076	197/7206	0.000225968820008
ko05110	Vibrio cholerae infection	21/1076	63/7206	0.000229762663039
ko04064	NF-kappa B signaling pathway	3/1076	96/7206	0.000254512118886
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1076	14/7206	0.000311983937273
ko04730	Long-term depression	24/1076	78/7206	0.0003261706215
ko04915	Estrogen signaling pathway	35/1076	131/7206	0.000438235139897
ko05169	Epstein-Barr virus infection	14/1076	206/7206	0.000463103686918
ko04014	Ras signaling pathway	63/1076	279/7206	0.00056293205209
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1076	59/7206	0.000700137968456
ko05161	Hepatitis B	11/1076	173/7206	0.000727078801109
ko05140	Leishmaniasis	2/1076	75/7206	0.000907366083773
ko05162	Measles	6/1076	120/7206	0.00106389592029
ko04750	Inflammatory mediator regulation of TRP channels	32/1076	122/7206	0.0011596752566
ko04371	Apelin signaling pathway	42/1076	177/7206	0.0017969293296
ko04923	Regulation of lipolysis in adipocytes	22/1076	77/7206	0.00188366364277
ko04964	Proximal tubule bicarbonate reclamation	11/1076	29/7206	0.00202768746821
ko04626	Plant-pathogen interaction	8/1076	18/7206	0.00260476544614
ko04146	Peroxisome	4/1076	89/7206	0.00260503511984
ko04630	Jak-STAT signaling pathway	8/1076	132/7206	0.00278264855404
ko00240	Pyrimidine metabolism	6/1076	110/7206	0.00279112955537
ko01524	Platinum drug resistance	3/1076	76/7206	0.00336990272412
ko04612	Antigen processing and presentation	3/1076	77/7206	0.00337268613837
ko00480	Glutathione metabolism	1/1076	55/7206	0.003409663786
ko04640	Hematopoietic cell lineage	2/1076	64/7206	0.00418887487517
ko00590	Arachidonic acid metabolism	1/1076	52/7206	0.0050120536401
ko00330	Arginine and proline metabolism	2/1076	61/7206	0.00608595799413
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1076	100/7206	0.00697555140036
ko05219	Bladder cancer	1/1076	48/7206	0.00711779380429
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1076	182/7206	0.00824010606829
ko04916	Melanogenesis	33/1076	142/7206	0.00837351010237
ko04668	TNF signaling pathway	8/1076	120/7206	0.00913618649594
ko04110	Cell cycle	11/1076	145/7206	0.00939857329265
ko04912	GnRH signaling pathway	29/1076	122/7206	0.00972724134318
ko05144	Malaria	1/1076	45/7206	0.0105668146405
ko00071	Fatty acid degradation	1/1076	45/7206	0.0105668146405
ko03022	Basal transcription factors	1/1076	44/7206	0.0105695612947
ko04210	Apoptosis	15/1076	180/7206	0.0106326763793
ko03420	Nucleotide excision repair	1/1076	46/7206	0.0108677860407
ko05145	Toxoplasmosis	9/1076	126/7206	0.011163658981
ko04510	Focal adhesion	23/1076	240/7206	0.0164216081466
ko00280	Valine, leucine and isoleucine degradation	2/1076	54/7206	0.0192229057669
ko05131	Shigellosis	5/1076	82/7206	0.0192338984274
ko03018	RNA degradation	5/1076	84/7206	0.0195841715113
ko04622	RIG-I-like receptor signaling pathway	3/1076	62/7206	0.0196398989677
ko04214	Apoptosis - fly	4/1076	72/7206	0.0197597465068
ko00310	Lysine degradation	4/1076	73/7206	0.019821697486
ko04918	Thyroid hormone synthesis	21/1076	86/7206	0.0209790943243
ko05215	Prostate cancer	8/1076	111/7206	0.0214920803764
ko04114	Oocyte meiosis	31/1076	139/7206	0.0215066349295
ko04620	Toll-like receptor signaling pathway	7/1076	100/7206	0.023040896872
ko01200	Carbon metabolism	10/1076	128/7206	0.0233670733948
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1076	40/7206	0.0236202748952
ko00140	Steroid hormone biosynthesis	1/1076	41/7206	0.0245808015427
ko04015	Rap1 signaling pathway	55/1076	278/7206	0.0253139152692
ko00380	Tryptophan metabolism	2/1076	50/7206	0.0267798803198
ko03320	PPAR signaling pathway	4/1076	69/7206	0.0273578940287
ko04270	Vascular smooth muscle contraction	33/1076	154/7206	0.0291338912043
ko04658	Th1 and Th2 cell differentiation	7/1076	96/7206	0.0306214675242
ko04930	Type II diabetes mellitus	14/1076	54/7206	0.0328298268434
ko05133	Pertussis	6/1076	87/7206	0.0332668673333
ko00982	Drug metabolism - cytochrome P450	1/1076	37/7206	0.0348157346748
ko04140	Autophagy - animal	15/1076	164/7206	0.034865526485
ko04391	Hippo signaling pathway - fly	21/1076	90/7206	0.0355080274221
ko00620	Pyruvate metabolism	2/1076	46/7206	0.038243385115
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1076	92/7206	0.0388163966969
ko05321	Inflammatory bowel disease (IBD)	3/1076	56/7206	0.0388263592936
ko04217	Necroptosis	17/1076	178/7206	0.0425721955502
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/1076	26/7206	0.0458565324125
ko04115	p53 signaling pathway	5/1076	74/7206	0.0482610294798