ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	94/994	152/7206	5.63464966942e-44
ko04080	Neuroactive ligand-receptor interaction	166/994	423/7206	1.53126035089e-41
ko05033	Nicotine addiction	48/994	56/7206	8.77152561499e-34
ko05032	Morphine addiction	69/994	110/7206	5.43264695889e-33
ko04727	GABAergic synapse	68/994	110/7206	5.97090761998e-32
ko04713	Circadian entrainment	74/994	136/7206	1.43649727367e-29
ko04728	Dopaminergic synapse	85/994	185/7206	6.10475397094e-27
ko04723	Retrograde endocannabinoid signaling	79/994	175/7206	1.80804477749e-24
ko04725	Cholinergic synapse	71/994	160/7206	1.51670785152e-21
ko04911	Insulin secretion	58/994	117/7206	1.02387722393e-20
ko04726	Serotonergic synapse	60/994	137/7206	4.99129720768e-18
ko04024	cAMP signaling pathway	94/994	279/7206	5.13449568859e-18
ko04921	Oxytocin signaling pathway	75/994	209/7206	2.70379072635e-16
ko04020	Calcium signaling pathway	86/994	265/7206	1.94727834364e-15
ko04261	Adrenergic signaling in cardiomyocytes	72/994	205/7206	4.05464100569e-15
ko05031	Amphetamine addiction	43/994	91/7206	1.03808158331e-14
ko04720	Long-term potentiation	45/994	99/7206	1.49302793266e-14
ko04742	Taste transduction	33/994	61/7206	9.93857865252e-14
ko04721	Synaptic vesicle cycle	38/994	80/7206	3.07300682949e-13
ko05030	Cocaine addiction	34/994	73/7206	1.11375703551e-11
ko04970	Salivary secretion	39/994	95/7206	4.26526103653e-11
ko04744	Phototransduction	22/994	36/7206	5.28631891185e-11
ko04925	Aldosterone synthesis and secretion	41/994	105/7206	8.89871050618e-11
ko04971	Gastric acid secretion	39/994	98/7206	1.31382303065e-10
ko04010	MAPK signaling pathway	83/994	321/7206	3.92702151191e-09
ko04972	Pancreatic secretion	39/994	111/7206	9.09833657472e-09
ko03040	Spliceosome	1/994	145/7206	1.4403680421e-08
ko04060	Cytokine-cytokine receptor interaction	5/994	191/7206	1.78950483462e-07
ko04730	Long-term depression	29/994	78/7206	1.82627846569e-07
ko04072	Phospholipase D signaling pathway	54/994	197/7206	3.05040398719e-07
ko04022	cGMP-PKG signaling pathway	57/994	216/7206	6.03348392119e-07
ko05203	Viral carcinogenesis	13/994	277/7206	7.48622367556e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/994	74/7206	7.48960521331e-07
ko04070	Phosphatidylinositol signaling system	35/994	112/7206	1.38791469538e-06
ko05168	Herpes simplex infection	6/994	182/7206	3.12528456124e-06
ko04915	Estrogen signaling pathway	38/994	131/7206	4.38251433212e-06
ko04110	Cell cycle	4/994	145/7206	8.47761587758e-06
ko04360	Axon guidance	57/994	233/7206	1.05130629585e-05
ko04740	Olfactory transduction	26/994	80/7206	2.04134748963e-05
ko04540	Gap junction	36/994	128/7206	2.20776745048e-05
ko05322	Systemic lupus erythematosus	5/994	151/7206	2.2151893586e-05
ko04260	Cardiac muscle contraction	29/994	98/7206	4.12480625238e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/994	59/7206	6.91581028759e-05
ko04745	Phototransduction - fly	15/994	38/7206	7.75315176504e-05
ko03013	RNA transport	7/994	166/7206	8.42199415455e-05
ko05414	Dilated cardiomyopathy	31/994	112/7206	8.59941476071e-05
ko04918	Thyroid hormone synthesis	26/994	86/7206	9.65888652722e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/994	79/7206	0.0001079320766
ko05169	Epstein-Barr virus infection	12/994	206/7206	0.000302997490993
ko04141	Protein processing in endoplasmic reticulum	10/994	184/7206	0.00031970299728
ko04612	Antigen processing and presentation	1/994	77/7206	0.000322033123211
ko04750	Inflammatory mediator regulation of TRP channels	31/994	122/7206	0.000500540732249
ko04371	Apelin signaling pathway	41/994	177/7206	0.000575342514605
ko05164	Influenza A	9/994	167/7206	0.000602196906809
ko04924	Renin secretion	24/994	86/7206	0.000712719866655
ko05162	Measles	5/994	120/7206	0.000754541022866
ko04514	Cell adhesion molecules (CAMs)	32/994	130/7206	0.000758917092547
ko04912	GnRH signaling pathway	30/994	122/7206	0.00127340515707
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/994	14/7206	0.00131707220238
ko04350	TGF-beta signaling pathway	4/994	103/7206	0.00137746239205
ko03008	Ribosome biogenesis in eukaryotes	2/994	79/7206	0.00145691569423
ko04976	Bile secretion	22/994	80/7206	0.00152346409131
ko04640	Hematopoietic cell lineage	1/994	64/7206	0.00152674197965
ko04062	Chemokine signaling pathway	44/994	201/7206	0.00169550675067
ko05034	Alcoholism	49/994	238/7206	0.00298881275538
ko00310	Lysine degradation	2/994	73/7206	0.00310026153057
ko05202	Transcriptional misregulation in cancer	13/994	188/7206	0.00368862177037
ko04923	Regulation of lipolysis in adipocytes	20/994	77/7206	0.00407970850347
ko04916	Melanogenesis	32/994	142/7206	0.00432536146623
ko04630	Jak-STAT signaling pathway	8/994	132/7206	0.00703620095697
ko00240	Pyrimidine metabolism	6/994	110/7206	0.0076387549297
ko05205	Proteoglycans in cancer	23/994	271/7206	0.00894201879721
ko04621	NOD-like receptor signaling pathway	11/994	157/7206	0.00981380926771
ko03018	RNA degradation	4/994	84/7206	0.0106685130252
ko04064	NF-kappa B signaling pathway	5/994	96/7206	0.0106792462757
ko00260	Glycine, serine and threonine metabolism	1/994	48/7206	0.0110222211472
ko05231	Choline metabolism in cancer	29/994	134/7206	0.0111043099543
ko00513	Various types of N-glycan biosynthesis	12/994	42/7206	0.0111454824863
ko04550	Signaling pathways regulating pluripotency of stem cells	12/994	165/7206	0.0116495922702
ko04120	Ubiquitin mediated proteolysis	9/994	138/7206	0.0119291190493
ko00562	Inositol phosphate metabolism	21/994	89/7206	0.012213666473
ko04015	Rap1 signaling pathway	53/994	278/7206	0.0127028938494
ko04014	Ras signaling pathway	53/994	279/7206	0.0129660305961
ko00512	Mucin type O-glycan biosynthesis	9/994	29/7206	0.0131768767126
ko04964	Proximal tubule bicarbonate reclamation	9/994	29/7206	0.0131768767126
ko05418	Fluid shear stress and atherosclerosis	13/994	173/7206	0.0136408030364
ko05110	Vibrio cholerae infection	16/994	63/7206	0.0150174994939
ko00515	Mannose type O-glycan biosynthesis	8/994	25/7206	0.0157509049319
ko04930	Type II diabetes mellitus	14/994	54/7206	0.0157971235294
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/994	182/7206	0.015975662417
ko00071	Fatty acid degradation	1/994	45/7206	0.0163354334575
ko03420	Nucleotide excision repair	1/994	46/7206	0.0164760931159
ko04142	Lysosome	11/994	151/7206	0.0166597220618
ko04114	Oocyte meiosis	29/994	139/7206	0.0182160047758
ko05321	Inflammatory bowel disease (IBD)	2/994	56/7206	0.0192339065361
ko04146	Peroxisome	5/994	89/7206	0.0199673310296
ko05222	Small cell lung cancer	5/994	89/7206	0.0199673310296
ko05016	Huntington's disease	18/994	215/7206	0.0203334721846
ko04071	Sphingolipid signaling pathway	33/994	162/7206	0.0204113402535
ko03320	PPAR signaling pathway	3/994	69/7206	0.0208300787561
ko04960	Aldosterone-regulated sodium reabsorption	11/994	41/7206	0.0222496567753
ko04270	Vascular smooth muscle contraction	31/994	154/7206	0.0248321641364
ko05410	Hypertrophic cardiomyopathy (HCM)	22/994	100/7206	0.0269272376479
ko00480	Glutathione metabolism	2/994	55/7206	0.0282946339406
ko05140	Leishmaniasis	4/994	75/7206	0.0282953682276
ko04210	Apoptosis	15/994	180/7206	0.0285714474005
ko04320	Dorso-ventral axis formation	9/994	31/7206	0.0305198338152
ko04670	Leukocyte transendothelial migration	12/994	151/7206	0.0319102818123
ko04510	Focal adhesion	22/994	240/7206	0.0357349256759
ko00980	Metabolism of xenobiotics by cytochrome P450	1/994	40/7206	0.0359594393951
ko04973	Carbohydrate digestion and absorption	11/994	42/7206	0.0387867509768
ko04214	Apoptosis - fly	4/994	72/7206	0.0388531987682
ko04115	p53 signaling pathway	4/994	74/7206	0.0397827226091
ko00330	Arginine and proline metabolism	3/994	61/7206	0.0400017308002
ko04622	RIG-I-like receptor signaling pathway	3/994	62/7206	0.0402207561339
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/994	15/7206	0.0450858445721
ko05010	Alzheimer's disease	38/994	202/7206	0.0483676662163