ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1169	423/7206	1.13592907402e-50
ko04724	Glutamatergic synapse	89/1169	152/7206	3.81538767099e-33
ko05032	Morphine addiction	69/1169	110/7206	1.79361613926e-28
ko04713	Circadian entrainment	76/1169	136/7206	1.37266988302e-26
ko05033	Nicotine addiction	45/1169	56/7206	3.30338721157e-26
ko04727	GABAergic synapse	64/1169	110/7206	7.15224458447e-24
ko04725	Cholinergic synapse	79/1169	160/7206	6.12178798701e-23
ko04728	Dopaminergic synapse	85/1169	185/7206	6.14206632605e-22
ko04721	Synaptic vesicle cycle	49/1169	80/7206	6.85452887983e-20
ko04723	Retrograde endocannabinoid signaling	78/1169	175/7206	3.18995347616e-19
ko04024	cAMP signaling pathway	105/1169	279/7206	1.10879734689e-18
ko04020	Calcium signaling pathway	99/1169	265/7206	1.97736380301e-17
ko04742	Taste transduction	38/1169	61/7206	4.67671387436e-16
ko04911	Insulin secretion	55/1169	117/7206	3.99330481882e-15
ko04726	Serotonergic synapse	60/1169	137/7206	1.27549907064e-14
ko04921	Oxytocin signaling pathway	78/1169	209/7206	5.97214020432e-14
ko04261	Adrenergic signaling in cardiomyocytes	75/1169	205/7206	6.74196491389e-13
ko04360	Axon guidance	78/1169	233/7206	4.53963444586e-11
ko05031	Amphetamine addiction	41/1169	91/7206	7.1575820156e-11
ko04970	Salivary secretion	42/1169	95/7206	8.84112174773e-11
ko04720	Long-term potentiation	43/1169	99/7206	1.0653534306e-10
ko03040	Spliceosome	1/1169	145/7206	3.19999294633e-10
ko04744	Phototransduction	21/1169	36/7206	1.03890169784e-08
ko04971	Gastric acid secretion	39/1169	98/7206	1.61142983502e-08
ko04022	cGMP-PKG signaling pathway	67/1169	216/7206	5.06946690352e-08
ko04925	Aldosterone synthesis and secretion	40/1169	105/7206	5.23086011917e-08
ko05322	Systemic lupus erythematosus	4/1169	151/7206	1.36889301206e-07
ko03013	RNA transport	6/1169	166/7206	5.46941570713e-07
ko05203	Viral carcinogenesis	18/1169	277/7206	1.11867605624e-06
ko05030	Cocaine addiction	29/1169	73/7206	1.16840138236e-06
ko04740	Olfactory transduction	31/1169	80/7206	1.60612811182e-06
ko04010	MAPK signaling pathway	85/1169	321/7206	1.83688499126e-06
ko05168	Herpes simplex infection	9/1169	182/7206	3.42851841863e-06
ko05164	Influenza A	8/1169	167/7206	6.30585087056e-06
ko04972	Pancreatic secretion	37/1169	111/7206	6.86169051845e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1169	74/7206	7.41518261826e-06
ko04621	NOD-like receptor signaling pathway	7/1169	157/7206	8.27496155844e-06
ko04540	Gap junction	41/1169	128/7206	8.38869390544e-06
ko04014	Ras signaling pathway	74/1169	279/7206	9.26383748276e-06
ko04514	Cell adhesion molecules (CAMs)	41/1169	130/7206	1.11079364899e-05
ko04070	Phosphatidylinositol signaling system	37/1169	112/7206	1.20275036956e-05
ko04060	Cytokine-cytokine receptor interaction	11/1169	191/7206	1.48570659231e-05
ko04730	Long-term depression	28/1169	78/7206	1.85567192152e-05
ko04120	Ubiquitin mediated proteolysis	6/1169	138/7206	2.05967655238e-05
ko04924	Renin secretion	30/1169	86/7206	2.10386744738e-05
ko04141	Protein processing in endoplasmic reticulum	11/1169	184/7206	4.04840266407e-05
ko04072	Phospholipase D signaling pathway	54/1169	197/7206	5.0725064592e-05
ko04966	Collecting duct acid secretion	13/1169	26/7206	6.55842798254e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1169	79/7206	7.9947692548e-05
ko04745	Phototransduction - fly	16/1169	38/7206	0.000131358626111
ko05414	Dilated cardiomyopathy	34/1169	112/7206	0.000149386857044
ko04610	Complement and coagulation cascades	2/1169	79/7206	0.00017205850532
ko03008	Ribosome biogenesis in eukaryotes	2/1169	79/7206	0.00017205850532
ko04612	Antigen processing and presentation	2/1169	77/7206	0.000257559551244
ko04750	Inflammatory mediator regulation of TRP channels	36/1169	122/7206	0.000260480872434
ko04371	Apelin signaling pathway	47/1169	177/7206	0.000397448076681
ko04915	Estrogen signaling pathway	37/1169	131/7206	0.000448866045007
ko04923	Regulation of lipolysis in adipocytes	25/1169	77/7206	0.000452229076987
ko04976	Bile secretion	25/1169	80/7206	0.000682385657559
ko04260	Cardiac muscle contraction	29/1169	98/7206	0.000790904357989
ko00240	Pyrimidine metabolism	6/1169	110/7206	0.000969318228001
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1169	59/7206	0.000998129198226
ko04640	Hematopoietic cell lineage	2/1169	64/7206	0.00181546815915
ko05140	Leishmaniasis	3/1169	75/7206	0.00229065402358
ko04916	Melanogenesis	37/1169	142/7206	0.00256806235261
ko00330	Arginine and proline metabolism	2/1169	61/7206	0.00266077479051
ko05110	Vibrio cholerae infection	20/1169	63/7206	0.00283787905558
ko04110	Cell cycle	11/1169	145/7206	0.00290508399303
ko05205	Proteoglycans in cancer	27/1169	271/7206	0.00322571650942
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1169	14/7206	0.00347439124307
ko04146	Peroxisome	5/1169	89/7206	0.00358513868196
ko04964	Proximal tubule bicarbonate reclamation	11/1169	29/7206	0.00397837978234
ko03420	Nucleotide excision repair	1/1169	46/7206	0.00444199219096
ko04626	Plant-pathogen interaction	8/1169	18/7206	0.00444780107464
ko04015	Rap1 signaling pathway	63/1169	278/7206	0.0046198488949
ko00260	Glycine, serine and threonine metabolism	1/1169	48/7206	0.00472948244263
ko04064	NF-kappa B signaling pathway	6/1169	96/7206	0.00499062340852
ko03022	Basal transcription factors	1/1169	44/7206	0.00668363368176
ko00071	Fatty acid degradation	1/1169	45/7206	0.00690409362169
ko05162	Measles	9/1169	120/7206	0.00814484320452
ko00280	Valine, leucine and isoleucine degradation	2/1169	54/7206	0.00842488667788
ko00480	Glutathione metabolism	2/1169	55/7206	0.00873920288395
ko00562	Inositol phosphate metabolism	24/1169	89/7206	0.00876130172801
ko05169	Epstein-Barr virus infection	20/1169	206/7206	0.00930856534521
ko04214	Apoptosis - fly	4/1169	72/7206	0.00965917874158
ko05131	Shigellosis	5/1169	82/7206	0.00972109718591
ko00310	Lysine degradation	4/1169	73/7206	0.00977254068958
ko00140	Steroid hormone biosynthesis	1/1169	41/7206	0.00998403246145
ko00590	Arachidonic acid metabolism	2/1169	52/7206	0.0124883145143
ko04217	Necroptosis	17/1169	178/7206	0.0131417407222
ko04622	RIG-I-like receptor signaling pathway	3/1169	62/7206	0.0138386720206
ko04930	Type II diabetes mellitus	16/1169	54/7206	0.0141255553244
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1169	40/7206	0.0155257442762
ko04912	GnRH signaling pathway	30/1169	122/7206	0.017752357878
ko04657	IL-17 signaling pathway	6/1169	87/7206	0.0180111682263
ko04973	Carbohydrate digestion and absorption	13/1169	42/7206	0.018141360895
ko00380	Tryptophan metabolism	2/1169	50/7206	0.0185971250786
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1169	182/7206	0.0186896613861
ko04062	Chemokine signaling pathway	45/1169	201/7206	0.0196538938874
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1169	100/7206	0.0202513318889
ko05161	Hepatitis B	17/1169	173/7206	0.021099045257
ko04722	Neurotrophin signaling pathway	37/1169	160/7206	0.0221722001012
ko00982	Drug metabolism - cytochrome P450	1/1169	37/7206	0.0227301361079
ko03018	RNA degradation	6/1169	84/7206	0.0241873195035
ko04115	p53 signaling pathway	5/1169	74/7206	0.0253311649418
ko05144	Malaria	2/1169	45/7206	0.0255624082941
ko00620	Pyruvate metabolism	2/1169	46/7206	0.0256661351039
ko05321	Inflammatory bowel disease (IBD)	3/1169	56/7206	0.0270236397949
ko05231	Choline metabolism in cancer	31/1169	134/7206	0.0330689955486
ko04270	Vascular smooth muscle contraction	35/1169	154/7206	0.0349818366396
ko04658	Th1 and Th2 cell differentiation	8/1169	96/7206	0.0356235019207
ko04114	Oocyte meiosis	32/1169	139/7206	0.0357169389445
ko01200	Carbon metabolism	12/1169	128/7206	0.0386598814587
ko05133	Pertussis	7/1169	87/7206	0.0393611591545
ko04071	Sphingolipid signaling pathway	36/1169	162/7206	0.0404739061023
ko04630	Jak-STAT signaling pathway	13/1169	132/7206	0.0429769676824
ko03015	mRNA surveillance pathway	8/1169	93/7206	0.0466637756285
ko03320	PPAR signaling pathway	5/1169	69/7206	0.0471488605349