ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1270	423/7206	6.00882034943e-53
ko04724	Glutamatergic synapse	93/1270	152/7206	9.16288887569e-34
ko05033	Nicotine addiction	48/1270	56/7206	1.01682966321e-28
ko04713	Circadian entrainment	79/1270	136/7206	1.19717227561e-26
ko05032	Morphine addiction	69/1270	110/7206	3.26090943671e-26
ko04727	GABAergic synapse	66/1270	110/7206	1.54292537938e-23
ko04721	Synaptic vesicle cycle	53/1270	80/7206	4.9166121571e-22
ko04725	Cholinergic synapse	80/1270	160/7206	2.81533638716e-21
ko04728	Dopaminergic synapse	86/1270	185/7206	4.00282759103e-20
ko04020	Calcium signaling pathway	108/1270	265/7206	1.87234928951e-19
ko04024	cAMP signaling pathway	109/1270	279/7206	5.26506772756e-18
ko04723	Retrograde endocannabinoid signaling	78/1270	175/7206	5.02548436756e-17
ko04911	Insulin secretion	60/1270	117/7206	6.44228826612e-17
ko04726	Serotonergic synapse	65/1270	137/7206	4.94609416018e-16
ko04742	Taste transduction	39/1270	61/7206	9.57193292923e-16
ko04921	Oxytocin signaling pathway	84/1270	209/7206	6.96859905442e-15
ko04720	Long-term potentiation	50/1270	99/7206	5.76523061701e-14
ko04740	Olfactory transduction	42/1270	80/7206	1.13415339395e-12
ko05031	Amphetamine addiction	45/1270	91/7206	2.77746530545e-12
ko04970	Salivary secretion	46/1270	95/7206	4.12254753897e-12
ko04744	Phototransduction	25/1270	36/7206	9.46108573657e-12
ko03040	Spliceosome	1/1270	145/7206	2.59357585617e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1270	205/7206	4.60037779328e-11
ko04360	Axon guidance	79/1270	233/7206	1.26954889003e-09
ko04925	Aldosterone synthesis and secretion	44/1270	105/7206	5.27400079588e-09
ko04540	Gap junction	50/1270	128/7206	6.66157332338e-09
ko04022	cGMP-PKG signaling pathway	72/1270	216/7206	1.68556719692e-08
ko04971	Gastric acid secretion	41/1270	98/7206	1.94016920653e-08
ko05168	Herpes simplex infection	8/1270	182/7206	9.87829275062e-08
ko05030	Cocaine addiction	32/1270	73/7206	1.53219283938e-07
ko05203	Viral carcinogenesis	19/1270	277/7206	1.89167695511e-07
ko03013	RNA transport	7/1270	166/7206	2.52124128922e-07
ko04621	NOD-like receptor signaling pathway	7/1270	157/7206	1.15110178223e-06
ko05322	Systemic lupus erythematosus	7/1270	151/7206	2.30632713993e-06
ko04010	MAPK signaling pathway	90/1270	321/7206	2.76344794126e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1270	74/7206	3.32150986642e-06
ko04972	Pancreatic secretion	40/1270	111/7206	3.3753212314e-06
ko04730	Long-term depression	31/1270	78/7206	3.38577583749e-06
ko04120	Ubiquitin mediated proteolysis	6/1270	138/7206	4.16200637757e-06
ko04141	Protein processing in endoplasmic reticulum	11/1270	184/7206	4.75911587258e-06
ko04060	Cytokine-cytokine receptor interaction	12/1270	191/7206	4.83459832468e-06
ko04966	Collecting duct acid secretion	15/1270	26/7206	5.00693976479e-06
ko04514	Cell adhesion molecules (CAMs)	44/1270	130/7206	6.73602023144e-06
ko04924	Renin secretion	32/1270	86/7206	1.23015229927e-05
ko05164	Influenza A	10/1270	167/7206	1.24136244388e-05
ko04371	Apelin signaling pathway	53/1270	177/7206	5.22993666044e-05
ko04014	Ras signaling pathway	76/1270	279/7206	5.39487873938e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1270	79/7206	7.18015501275e-05
ko04745	Phototransduction - fly	17/1270	38/7206	9.42378562898e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1270	122/7206	9.9748650232e-05
ko05169	Epstein-Barr virus infection	17/1270	206/7206	0.00013134367082
ko04260	Cardiac muscle contraction	33/1270	98/7206	0.000134312739973
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1270	79/7206	0.000140399215625
ko04976	Bile secretion	28/1270	80/7206	0.000165666883999
ko04110	Cell cycle	10/1270	145/7206	0.00024289555284
ko04610	Complement and coagulation cascades	3/1270	79/7206	0.000303740725894
ko05110	Vibrio cholerae infection	23/1270	63/7206	0.000331926253449
ko04146	Peroxisome	4/1270	89/7206	0.000368158835443
ko05414	Dilated cardiomyopathy	35/1270	112/7206	0.000389005230198
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1270	59/7206	0.000392062395456
ko04612	Antigen processing and presentation	3/1270	77/7206	0.000444275740887
ko04072	Phospholipase D signaling pathway	54/1270	197/7206	0.000581530869139
ko04064	NF-kappa B signaling pathway	5/1270	96/7206	0.000606649036587
ko04964	Proximal tubule bicarbonate reclamation	13/1270	29/7206	0.000614549804845
ko05162	Measles	8/1270	120/7206	0.000649429976793
ko05140	Leishmaniasis	3/1270	75/7206	0.000652163716741
ko04070	Phosphatidylinositol signaling system	34/1270	112/7206	0.000986819758856
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1270	14/7206	0.00099952397266
ko04915	Estrogen signaling pathway	38/1270	131/7206	0.00110265735683
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1270	182/7206	0.0021226202568
ko00240	Pyrimidine metabolism	8/1270	110/7206	0.00234023471541
ko03420	Nucleotide excision repair	1/1270	46/7206	0.00281062329514
ko05145	Toxoplasmosis	10/1270	126/7206	0.00292105137567
ko05205	Proteoglycans in cancer	30/1270	271/7206	0.00331405113751
ko05131	Shigellosis	5/1270	82/7206	0.00333187424997
ko04916	Melanogenesis	39/1270	142/7206	0.00354466632591
ko00280	Valine, leucine and isoleucine degradation	2/1270	54/7206	0.00363165626715
ko04923	Regulation of lipolysis in adipocytes	24/1270	77/7206	0.00372401125048
ko03022	Basal transcription factors	1/1270	44/7206	0.00433083436707
ko00310	Lysine degradation	4/1270	73/7206	0.00474901322801
ko04912	GnRH signaling pathway	34/1270	122/7206	0.00540721431615
ko00330	Arginine and proline metabolism	3/1270	61/7206	0.00614493658944
ko04622	RIG-I-like receptor signaling pathway	3/1270	62/7206	0.00639919564212
ko05133	Pertussis	6/1270	87/7206	0.00653960094399
ko04217	Necroptosis	18/1270	178/7206	0.0068674216103
ko04626	Plant-pathogen interaction	8/1270	18/7206	0.00749555737629
ko04015	Rap1 signaling pathway	66/1270	278/7206	0.00798294246686
ko03018	RNA degradation	6/1270	84/7206	0.00891460720125
ko01524	Platinum drug resistance	5/1270	76/7206	0.00924915633649
ko00630	Glyoxylate and dicarboxylate metabolism	1/1270	38/7206	0.00940740821188
ko04270	Vascular smooth muscle contraction	40/1270	154/7206	0.00982869282407
ko04668	TNF signaling pathway	11/1270	120/7206	0.0111036104486
ko05418	Fluid shear stress and atherosclerosis	18/1270	173/7206	0.0111718827048
ko04960	Aldosterone-regulated sodium reabsorption	14/1270	41/7206	0.0114767727111
ko00260	Glycine, serine and threonine metabolism	2/1270	48/7206	0.0118434629932
ko00480	Glutathione metabolism	3/1270	55/7206	0.0125084955904
ko04214	Apoptosis - fly	5/1270	72/7206	0.0126498770914
ko04115	p53 signaling pathway	5/1270	74/7206	0.0130113210694
ko04658	Th1 and Th2 cell differentiation	8/1270	96/7206	0.0145390024481
ko04657	IL-17 signaling pathway	7/1270	87/7206	0.0156028743045
ko00071	Fatty acid degradation	2/1270	45/7206	0.0169187825245
ko05161	Hepatitis B	19/1270	173/7206	0.0197810862737
ko00640	Propanoate metabolism	1/1270	34/7206	0.0215759720814
ko00860	Porphyrin and chlorophyll metabolism	1/1270	34/7206	0.0215759720814
ko05231	Choline metabolism in cancer	34/1270	134/7206	0.0217490933182
ko05132	Salmonella infection	9/1270	98/7206	0.0233912386044
ko04620	Toll-like receptor signaling pathway	9/1270	100/7206	0.0236609665032
ko05214	Glioma	22/1270	79/7206	0.0246064671373
ko01200	Carbon metabolism	13/1270	128/7206	0.0255057546191
ko00590	Arachidonic acid metabolism	3/1270	52/7206	0.0261953838696
ko04930	Type II diabetes mellitus	16/1270	54/7206	0.0295435804152
ko04918	Thyroid hormone synthesis	23/1270	86/7206	0.0320210580129
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1270	100/7206	0.0337127112069
ko05166	HTLV-I infection	38/1270	292/7206	0.0342013626301
ko05321	Inflammatory bowel disease (IBD)	4/1270	56/7206	0.0348514479634
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1270	40/7206	0.0355130952302
ko04630	Jak-STAT signaling pathway	14/1270	132/7206	0.0370386549165
ko04973	Carbohydrate digestion and absorption	13/1270	42/7206	0.0388290903037
ko04142	Lysosome	17/1270	151/7206	0.0397433129052
ko03015	mRNA surveillance pathway	9/1270	93/7206	0.0402264920188
ko00561	Glycerolipid metabolism	5/1270	63/7206	0.0450322250012
ko00600	Sphingolipid metabolism	5/1270	63/7206	0.0450322250012
ko04640	Hematopoietic cell lineage	5/1270	64/7206	0.045902838812
ko05034	Alcoholism	54/1270	238/7206	0.0460780114299