ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 38/354 145/7206 2.91272838046e-18 ko04110 Cell cycle 34/354 145/7206 7.39830280084e-15 ko03440 Homologous recombination 19/354 41/7206 7.71644759558e-15 ko03013 RNA transport 36/354 166/7206 1.55399270878e-14 ko04111 Cell cycle - yeast 25/354 90/7206 5.18354476037e-13 ko03008 Ribosome biogenesis in eukaryotes 23/354 79/7206 1.53304378803e-12 ko03460 Fanconi anemia pathway 17/354 51/7206 1.235783924e-10 ko04113 Meiosis - yeast 17/354 70/7206 2.7909626886e-08 ko03410 Base excision repair 11/354 38/7206 1.2515795353e-06 ko04144 Endocytosis 2/354 342/7206 8.06708731041e-06 ko03030 DNA replication 10/354 38/7206 9.91915661629e-06 ko03018 RNA degradation 15/354 84/7206 1.1612680472e-05 ko04114 Oocyte meiosis 20/354 139/7206 1.28834445346e-05 ko04024 cAMP signaling pathway 2/354 279/7206 0.00017153712341 ko04914 Progesterone-mediated oocyte maturation 14/354 104/7206 0.000520807211199 ko04151 PI3K-Akt signaling pathway 6/354 390/7206 0.000628643665802 ko05166 HTLV-I infection 28/354 292/7206 0.000719951726134 ko05010 Alzheimer's disease 1/354 202/7206 0.000736539789146 ko04261 Adrenergic signaling in cardiomyocytes 1/354 205/7206 0.000766057911601 ko03022 Basal transcription factors 8/354 44/7206 0.00117303922902 ko04728 Dopaminergic synapse 1/354 185/7206 0.00156810336507 ko03420 Nucleotide excision repair 8/354 46/7206 0.00158525982662 ko04022 cGMP-PKG signaling pathway 2/354 216/7206 0.00212529349764 ko04723 Retrograde endocannabinoid signaling 1/354 175/7206 0.00227736082052 ko04371 Apelin signaling pathway 1/354 177/7206 0.00229116080219 ko04921 Oxytocin signaling pathway 2/354 209/7206 0.00304657364746 ko05322 Systemic lupus erythematosus 16/354 151/7206 0.00337429195691 ko03430 Mismatch repair 5/354 22/7206 0.00366271602876 ko04725 Cholinergic synapse 1/354 160/7206 0.00484512270415 ko04270 Vascular smooth muscle contraction 1/354 154/7206 0.00713937483553 ko04218 Cellular senescence 17/354 177/7206 0.00726780365349 ko04621 NOD-like receptor signaling pathway 1/354 157/7206 0.00742839781546 ko04139 Mitophagy - yeast 6/354 37/7206 0.00859986310754 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/354 182/7206 0.00876456031111 ko00310 Lysine degradation 9/354 73/7206 0.00905451762357 ko04115 p53 signaling pathway 9/354 74/7206 0.00987641549081 ko04015 Rap1 signaling pathway 5/354 278/7206 0.0102158423541 ko00240 Pyrimidine metabolism 12/354 110/7206 0.0112380231776 ko04726 Serotonergic synapse 1/354 137/7206 0.0149069985984 ko05145 Toxoplasmosis 1/354 126/7206 0.0213249345593 ko00190 Oxidative phosphorylation 1/354 127/7206 0.0213535280763 ko05142 Chagas disease (American trypanosomiasis) 1/354 130/7206 0.0217546271601 ko04915 Estrogen signaling pathway 1/354 131/7206 0.0219937244348 ko03015 mRNA surveillance pathway 10/354 93/7206 0.0243844090425 ko04152 AMPK signaling pathway 2/354 161/7206 0.0249299813447 ko04611 Platelet activation 2/354 163/7206 0.0253546166009 ko04140 Autophagy - animal 2/354 164/7206 0.0256377423039 ko04911 Insulin secretion 1/354 117/7206 0.030769309519 ko04668 TNF signaling pathway 1/354 120/7206 0.0309425896507 ko04750 Inflammatory mediator regulation of TRP channels 1/354 122/7206 0.0314196507508 ko04066 HIF-1 signaling pathway 1/354 123/7206 0.0317664911335 ko04510 Focal adhesion 5/354 240/7206 0.0333972040582 ko05206 MicroRNAs in cancer 15/354 177/7206 0.0336967728654 ko03450 Non-homologous end-joining 3/354 15/7206 0.0344433327158 ko05016 Huntington's disease 4/354 215/7206 0.0353863354542 ko05152 Tuberculosis 3/354 187/7206 0.0368950109656 ko04712 Circadian rhythm - plant 2/354 7/7206 0.0428905204606 ko04972 Pancreatic secretion 1/354 111/7206 0.0443679687978 ko04070 Phosphatidylinositol signaling system 1/354 112/7206 0.0445742158138 ko05414 Dilated cardiomyopathy 1/354 112/7206 0.0445742158138 ko05203 Viral carcinogenesis 21/354 277/7206 0.0456631924701 ko04120 Ubiquitin mediated proteolysis 12/354 138/7206 0.0457227663898 ko04062 Chemokine signaling pathway 4/354 201/7206 0.0470783935677 ko05217 Basal cell carcinoma 7/354 68/7206 0.0483076686364