ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1301	423/7206	4.40038872472e-56
ko04724	Glutamatergic synapse	97/1301	152/7206	1.61903762798e-36
ko05033	Nicotine addiction	50/1301	56/7206	3.23909697605e-31
ko05032	Morphine addiction	74/1301	110/7206	2.68046864399e-30
ko04713	Circadian entrainment	84/1301	136/7206	3.31879807429e-30
ko04727	GABAergic synapse	71/1301	110/7206	2.10007700429e-27
ko04728	Dopaminergic synapse	93/1301	185/7206	5.29479487339e-24
ko04725	Cholinergic synapse	82/1301	160/7206	5.61851729256e-22
ko04721	Synaptic vesicle cycle	51/1301	80/7206	1.2021479792e-19
ko04723	Retrograde endocannabinoid signaling	82/1301	175/7206	7.94387299499e-19
ko04020	Calcium signaling pathway	108/1301	265/7206	1.20796763207e-18
ko04911	Insulin secretion	63/1301	117/7206	1.44891432825e-18
ko04726	Serotonergic synapse	68/1301	137/7206	1.87625127936e-17
ko04024	cAMP signaling pathway	109/1301	279/7206	3.16479435362e-17
ko04921	Oxytocin signaling pathway	85/1301	209/7206	7.68939164111e-15
ko05031	Amphetamine addiction	49/1301	91/7206	1.0271293635e-14
ko04742	Taste transduction	38/1301	61/7206	1.77390866849e-14
ko04744	Phototransduction	27/1301	36/7206	1.17921389952e-13
ko04261	Adrenergic signaling in cardiomyocytes	80/1301	205/7206	8.55003432828e-13
ko04720	Long-term potentiation	48/1301	99/7206	3.29421627589e-12
ko05030	Cocaine addiction	38/1301	73/7206	4.08422679911e-11
ko04970	Salivary secretion	45/1301	95/7206	4.31549694224e-11
ko03040	Spliceosome	2/1301	145/7206	2.23186096942e-10
ko03010	Ribosome	1/1301	129/7206	3.4789266646e-10
ko04925	Aldosterone synthesis and secretion	45/1301	105/7206	3.21437507513e-09
ko04971	Gastric acid secretion	42/1301	98/7206	1.14591699612e-08
ko05322	Systemic lupus erythematosus	5/1301	151/7206	4.34899684506e-08
ko03013	RNA transport	7/1301	166/7206	1.09192944085e-07
ko04022	cGMP-PKG signaling pathway	70/1301	216/7206	2.15493513877e-07
ko04740	Olfactory transduction	34/1301	80/7206	3.96627626521e-07
ko04010	MAPK signaling pathway	94/1301	321/7206	5.09892389933e-07
ko04360	Axon guidance	73/1301	233/7206	5.81475609313e-07
ko04060	Cytokine-cytokine receptor interaction	11/1301	191/7206	7.94921830887e-07
ko04070	Phosphatidylinositol signaling system	42/1301	112/7206	1.26152246101e-06
ko05203	Viral carcinogenesis	22/1301	277/7206	1.45298269794e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1301	74/7206	1.76391448029e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	26/1301	59/7206	3.16953260265e-06
ko04745	Phototransduction - fly	19/1301	38/7206	7.09362918653e-06
ko04540	Gap junction	44/1301	128/7206	7.53582362097e-06
ko04621	NOD-like receptor signaling pathway	9/1301	157/7206	7.94040076095e-06
ko05168	Herpes simplex infection	12/1301	182/7206	8.95517062966e-06
ko04972	Pancreatic secretion	39/1301	111/7206	1.54840927727e-05
ko04072	Phospholipase D signaling pathway	60/1301	197/7206	1.89390397586e-05
ko04141	Protein processing in endoplasmic reticulum	13/1301	184/7206	2.40420630891e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1301	79/7206	4.4662831211e-05
ko05414	Dilated cardiomyopathy	38/1301	112/7206	5.33374865963e-05
ko05164	Influenza A	12/1301	167/7206	6.35113543278e-05
ko04711	Circadian rhythm - fly	9/1301	13/7206	7.0548331126e-05
ko04730	Long-term depression	29/1301	78/7206	7.42522353373e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1301	79/7206	8.43547236266e-05
ko04110	Cell cycle	10/1301	145/7206	0.000173396645972
ko04924	Renin secretion	30/1301	86/7206	0.000179856461242
ko05110	Vibrio cholerae infection	24/1301	63/7206	0.000183757657777
ko04750	Inflammatory mediator regulation of TRP channels	39/1301	122/7206	0.000187837893636
ko04710	Circadian rhythm	18/1301	43/7206	0.000230852818602
ko04612	Antigen processing and presentation	3/1301	77/7206	0.000294559954016
ko00520	Amino sugar and nucleotide sugar metabolism	1/1301	55/7206	0.000330190004534
ko04014	Ras signaling pathway	74/1301	279/7206	0.000333233335981
ko04064	NF-kappa B signaling pathway	5/1301	96/7206	0.000409629777683
ko04923	Regulation of lipolysis in adipocytes	27/1301	77/7206	0.000458443221729
ko04514	Cell adhesion molecules (CAMs)	40/1301	130/7206	0.000471555401849
ko04915	Estrogen signaling pathway	40/1301	131/7206	0.000497779923237
ko04976	Bile secretion	27/1301	80/7206	0.00064868696228
ko04966	Collecting duct acid secretion	12/1301	26/7206	0.000903047451235
ko05169	Epstein-Barr virus infection	20/1301	206/7206	0.000905910375964
ko04610	Complement and coagulation cascades	4/1301	79/7206	0.00106036772365
ko04260	Cardiac muscle contraction	31/1301	98/7206	0.00127638420346
ko05162	Measles	9/1301	120/7206	0.00165296384002
ko00240	Pyrimidine metabolism	8/1301	110/7206	0.00166220393193
ko03420	Nucleotide excision repair	1/1301	46/7206	0.00176257733146
ko04912	GnRH signaling pathway	36/1301	122/7206	0.00183252364394
ko04115	p53 signaling pathway	4/1301	74/7206	0.00218570246856
ko04930	Type II diabetes mellitus	19/1301	54/7206	0.00224455718823
ko05321	Inflammatory bowel disease (IBD)	2/1301	56/7206	0.00245914947385
ko04918	Thyroid hormone synthesis	27/1301	86/7206	0.00267118303344
ko03022	Basal transcription factors	1/1301	44/7206	0.00267128592326
ko05144	Malaria	1/1301	45/7206	0.00275367361641
ko00071	Fatty acid degradation	1/1301	45/7206	0.00275367361641
ko04146	Peroxisome	6/1301	89/7206	0.00328786503463
ko04371	Apelin signaling pathway	47/1301	177/7206	0.00405890212841
ko04622	RIG-I-like receptor signaling pathway	3/1301	62/7206	0.00417862334549
ko03320	PPAR signaling pathway	4/1301	69/7206	0.0044593266792
ko00590	Arachidonic acid metabolism	2/1301	52/7206	0.0055458618636
ko04630	Jak-STAT signaling pathway	12/1301	132/7206	0.00576864982013
ko05205	Proteoglycans in cancer	32/1301	271/7206	0.00601974910376
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1301	40/7206	0.00618907611151
ko03018	RNA degradation	6/1301	84/7206	0.00631584023105
ko05140	Leishmaniasis	5/1301	75/7206	0.00641949135614
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1301	14/7206	0.00646793289939
ko05016	Huntington's disease	24/1301	215/7206	0.00671969499282
ko04217	Necroptosis	19/1301	178/7206	0.00761689120314
ko04210	Apoptosis	19/1301	180/7206	0.0077269002865
ko04626	Plant-pathogen interaction	8/1301	18/7206	0.00870208002975
ko00310	Lysine degradation	5/1301	73/7206	0.00893516977831
ko03410	Base excision repair	1/1301	38/7206	0.00945469098197
ko05145	Toxoplasmosis	12/1301	126/7206	0.00987752295304
ko04922	Glucagon signaling pathway	35/1301	128/7206	0.0101797576374
ko04658	Th1 and Th2 cell differentiation	8/1301	96/7206	0.0106214867868
ko04015	Rap1 signaling pathway	67/1301	278/7206	0.0106888537831
ko04916	Melanogenesis	38/1301	142/7206	0.0107429188614
ko04657	IL-17 signaling pathway	7/1301	87/7206	0.0113269102793
ko05133	Pertussis	7/1301	87/7206	0.0113269102793
ko05222	Small cell lung cancer	7/1301	89/7206	0.0116781260636
ko05418	Fluid shear stress and atherosclerosis	19/1301	173/7206	0.0122594969008
ko05161	Hepatitis B	19/1301	173/7206	0.0122594969008
ko00480	Glutathione metabolism	3/1301	55/7206	0.0124781094281
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1301	100/7206	0.0125452931586
ko00500	Starch and sucrose metabolism	1/1301	35/7206	0.013940205943
ko05231	Choline metabolism in cancer	35/1301	134/7206	0.0172418310888
ko00562	Inositol phosphate metabolism	25/1301	89/7206	0.0178618063246
ko05131	Shigellosis	7/1301	82/7206	0.0207061069432
ko05202	Transcriptional misregulation in cancer	22/1301	188/7206	0.0208443486726
ko04213	Longevity regulating pathway - multiple species	24/1301	86/7206	0.0231388677737
ko00140	Steroid hormone biosynthesis	2/1301	41/7206	0.0240173060977
ko04120	Ubiquitin mediated proteolysis	15/1301	138/7206	0.0251727820187
ko00512	Mucin type O-glycan biosynthesis	10/1301	29/7206	0.0288748615082
ko04964	Proximal tubule bicarbonate reclamation	10/1301	29/7206	0.0288748615082
ko04214	Apoptosis - fly	6/1301	72/7206	0.0302671165781
ko04142	Lysosome	17/1301	151/7206	0.0317214910372
ko00515	Mannose type O-glycan biosynthesis	9/1301	25/7206	0.0323100208222
ko04062	Chemokine signaling pathway	48/1301	201/7206	0.0324638393811
ko04640	Hematopoietic cell lineage	5/1301	64/7206	0.0326351450391
ko04114	Oocyte meiosis	35/1301	139/7206	0.0337905808585
ko04270	Vascular smooth muscle contraction	38/1301	154/7206	0.0342494046294
ko00630	Glyoxylate and dicarboxylate metabolism	2/1301	38/7206	0.0349136212619
ko00270	Cysteine and methionine metabolism	3/1301	47/7206	0.0354107890507
ko04620	Toll-like receptor signaling pathway	10/1301	100/7206	0.0355228461669
ko05204	Chemical carcinogenesis	3/1301	48/7206	0.0360651649725
ko04960	Aldosterone-regulated sodium reabsorption	13/1301	41/7206	0.0383343344806
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1301	15/7206	0.0390559063413
ko04510	Focal adhesion	31/1301	240/7206	0.0400171669148
ko00513	Various types of N-glycan biosynthesis	13/1301	42/7206	0.0415688848814
ko00330	Arginine and proline metabolism	5/1301	61/7206	0.0443358860206
ko05215	Prostate cancer	12/1301	111/7206	0.0462949049994
ko04722	Neurotrophin signaling pathway	39/1301	160/7206	0.0474582084173
ko04218	Cellular senescence	22/1301	177/7206	0.0479899793168
ko05034	Alcoholism	55/1301	238/7206	0.0481921629842
ko00280	Valine, leucine and isoleucine degradation	4/1301	54/7206	0.0484737204481
ko05320	Autoimmune thyroid disease	1/1301	29/7206	0.0485698803318