ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/573 191/7206 8.94190130829e-13 ko04621 NOD-like receptor signaling pathway 34/573 157/7206 4.6386190767e-08 ko04650 Natural killer cell mediated cytotoxicity 25/573 97/7206 8.34928655112e-08 ko04380 Osteoclast differentiation 30/573 134/7206 1.33757432727e-07 ko05340 Primary immunodeficiency 13/573 30/7206 1.50235330839e-07 ko04137 Mitophagy - animal 22/573 82/7206 2.34296522587e-07 ko05164 Influenza A 33/573 167/7206 7.03772774465e-07 ko05321 Inflammatory bowel disease (IBD) 17/573 56/7206 8.35616256365e-07 ko05140 Leishmaniasis 19/573 75/7206 3.99224982269e-06 ko04064 NF-kappa B signaling pathway 22/573 96/7206 4.24905656971e-06 ko05162 Measles 25/573 120/7206 5.98277487601e-06 ko04620 Toll-like receptor signaling pathway 22/573 100/7206 8.62511916397e-06 ko04217 Necroptosis 32/573 178/7206 1.40938900026e-05 ko05145 Toxoplasmosis 25/573 126/7206 1.47374503499e-05 ko05152 Tuberculosis 32/573 187/7206 2.72109301538e-05 ko04660 T cell receptor signaling pathway 24/573 124/7206 3.35020676462e-05 ko04610 Complement and coagulation cascades 18/573 79/7206 3.43318584504e-05 ko05320 Autoimmune thyroid disease 10/573 29/7206 4.66699544078e-05 ko05330 Allograft rejection 9/573 24/7206 5.26295650493e-05 ko04659 Th17 cell differentiation 21/573 106/7206 7.23324738573e-05 ko00120 Primary bile acid biosynthesis 8/573 20/7206 8.11387769398e-05 ko04672 Intestinal immune network for IgA production 11/573 37/7206 9.2156146381e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 31/573 191/7206 0.000110208141301 ko03040 Spliceosome 1/573 145/7206 0.000136627967067 ko04658 Th1 and Th2 cell differentiation 19/573 96/7206 0.000160455976339 ko03010 Ribosome 1/573 129/7206 0.0004355338896 ko04068 FoxO signaling pathway 26/573 167/7206 0.000754368009568 ko04062 Chemokine signaling pathway 30/573 201/7206 0.00077611659628 ko00140 Steroid hormone biosynthesis 10/573 41/7206 0.00109247971723 ko03013 RNA transport 3/573 166/7206 0.00116974492871 ko04640 Hematopoietic cell lineage 13/573 64/7206 0.00132556925812 ko00051 Fructose and mannose metabolism 10/573 42/7206 0.00133389707398 ko05161 Hepatitis B 26/573 173/7206 0.00147474612255 ko05150 Staphylococcus aureus infection 9/573 36/7206 0.00159736221834 ko04668 TNF signaling pathway 20/573 120/7206 0.00164659171255 ko04630 Jak-STAT signaling pathway 21/573 132/7206 0.00179253839709 ko05133 Pertussis 16/573 87/7206 0.00190827144819 ko05332 Graft-versus-host disease 6/573 18/7206 0.00199409440585 ko05323 Rheumatoid arthritis 16/573 89/7206 0.00214034379776 ko05144 Malaria 10/573 45/7206 0.00232906184894 ko00592 alpha-Linolenic acid metabolism 6/573 19/7206 0.00272127994004 ko05168 Herpes simplex infection 26/573 182/7206 0.00316401658957 ko04623 Cytosolic DNA-sensing pathway 9/573 41/7206 0.00415942184712 ko04612 Antigen processing and presentation 14/573 77/7206 0.00430262037265 ko04662 B cell receptor signaling pathway 15/573 88/7206 0.00430509118429 ko04146 Peroxisome 15/573 89/7206 0.00468090589795 ko05034 Alcoholism 8/573 238/7206 0.00485331519867 ko04210 Apoptosis 25/573 180/7206 0.00505555731846 ko03015 mRNA surveillance pathway 1/573 93/7206 0.00638337923075 ko00590 Arachidonic acid metabolism 10/573 52/7206 0.00698503043007 ko04145 Phagosome 23/573 162/7206 0.00729479251649 ko05142 Chagas disease (American trypanosomiasis) 19/573 130/7206 0.00823009488604 ko05310 Asthma 5/573 17/7206 0.00864033120736 ko00360 Phenylalanine metabolism 5/573 17/7206 0.00864033120736 ko04391 Hippo signaling pathway - fly 1/573 90/7206 0.00943549965299 ko05132 Salmonella infection 15/573 98/7206 0.0127743589652 ko04390 Hippo signaling pathway 6/573 188/7206 0.0129565370105 ko00350 Tyrosine metabolism 7/573 33/7206 0.0133865313747 ko04933 AGE-RAGE signaling pathway in diabetic complications 19/573 135/7206 0.0145077231993 ko04622 RIG-I-like receptor signaling pathway 11/573 62/7206 0.0146394440239 ko04310 Wnt signaling pathway 6/573 181/7206 0.0170434532874 ko04710 Circadian rhythm 8/573 43/7206 0.0183909292475 ko04110 Cell cycle 4/573 145/7206 0.0184541952856 ko04664 Fc epsilon RI signaling pathway 12/573 77/7206 0.0193064492962 ko04670 Leukocyte transendothelial migration 20/573 151/7206 0.0215567588417 ko04723 Retrograde endocannabinoid signaling 6/573 175/7206 0.0226338234067 ko00982 Drug metabolism - cytochrome P450 7/573 37/7206 0.0245115685726 ko05418 Fluid shear stress and atherosclerosis 22/573 173/7206 0.0311454019524 ko04080 Neuroactive ligand-receptor interaction 22/573 423/7206 0.032566968253 ko04136 Autophagy - other 6/573 31/7206 0.0327505478958 ko04972 Pancreatic secretion 3/573 111/7206 0.0335238861275 ko04360 Axon guidance 10/573 233/7206 0.0355498107686 ko04940 Type I diabetes mellitus 6/573 32/7206 0.0377006888101 ko00950 Isoquinoline alkaloid biosynthesis 3/573 10/7206 0.0393436629762 ko05217 Basal cell carcinoma 1/573 68/7206 0.0415476116113 ko04666 Fc gamma R-mediated phagocytosis 16/573 122/7206 0.0416158588605 ko01040 Biosynthesis of unsaturated fatty acids 5/573 25/7206 0.0438644848901 ko04540 Gap junction 4/573 128/7206 0.0455853341099 ko05134 Legionellosis 11/573 74/7206 0.0466824003826 ko05032 Morphine addiction 3/573 110/7206 0.0476703249451 ko05160 Hepatitis C 19/573 153/7206 0.0481447126082 ko04626 Plant-pathogen interaction 4/573 18/7206 0.0494343548284 ko04070 Phosphatidylinositol signaling system 15/573 112/7206 0.0495015574747