ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1245	423/7206	6.25015475287e-51
ko04724	Glutamatergic synapse	90/1245	152/7206	7.97551390723e-32
ko05033	Nicotine addiction	48/1245	56/7206	3.97278192561e-29
ko05032	Morphine addiction	68/1245	110/7206	7.83280644672e-26
ko04721	Synaptic vesicle cycle	55/1245	80/7206	1.76257996366e-24
ko04713	Circadian entrainment	75/1245	136/7206	5.7396725149e-24
ko04727	GABAergic synapse	65/1245	110/7206	3.55845357567e-23
ko04725	Cholinergic synapse	76/1245	160/7206	4.11048494193e-19
ko04728	Dopaminergic synapse	82/1245	185/7206	3.29305567559e-18
ko04723	Retrograde endocannabinoid signaling	77/1245	175/7206	6.11069150158e-17
ko04024	cAMP signaling pathway	105/1245	279/7206	1.25494633713e-16
ko04742	Taste transduction	39/1245	61/7206	4.76373578965e-16
ko04020	Calcium signaling pathway	98/1245	265/7206	7.14945861696e-15
ko04911	Insulin secretion	56/1245	117/7206	1.41768843034e-14
ko04744	Phototransduction	27/1245	36/7206	3.85101432095e-14
ko04921	Oxytocin signaling pathway	79/1245	209/7206	6.40297937556e-13
ko04726	Serotonergic synapse	59/1245	137/7206	9.10089909761e-13
ko04740	Olfactory transduction	40/1245	80/7206	1.54692860689e-11
ko03040	Spliceosome	1/1245	145/7206	4.30710614507e-11
ko04720	Long-term potentiation	45/1245	99/7206	5.28748903992e-11
ko04970	Salivary secretion	43/1245	95/7206	1.68513474606e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1245	205/7206	2.01142585417e-10
ko05031	Amphetamine addiction	40/1245	91/7206	2.14368916576e-09
ko05203	Viral carcinogenesis	15/1245	277/7206	3.07093412788e-09
ko05168	Herpes simplex infection	6/1245	182/7206	6.53609593768e-09
ko04360	Axon guidance	75/1245	233/7206	1.63978479248e-08
ko04925	Aldosterone synthesis and secretion	41/1245	105/7206	1.28350737375e-07
ko03013	RNA transport	7/1245	166/7206	3.78417573736e-07
ko04971	Gastric acid secretion	38/1245	98/7206	4.68327917265e-07
ko04966	Collecting duct acid secretion	16/1245	26/7206	5.37575128259e-07
ko04540	Gap junction	45/1245	128/7206	7.92198031853e-07
ko05164	Influenza A	8/1245	167/7206	1.33577611457e-06
ko05030	Cocaine addiction	30/1245	73/7206	2.18540484338e-06
ko04022	cGMP-PKG signaling pathway	65/1245	216/7206	2.39783958706e-06
ko04060	Cytokine-cytokine receptor interaction	11/1245	191/7206	2.46594246889e-06
ko04621	NOD-like receptor signaling pathway	8/1245	157/7206	5.61030643064e-06
ko04120	Ubiquitin mediated proteolysis	6/1245	138/7206	6.22606372143e-06
ko04924	Renin secretion	32/1245	86/7206	8.78095141589e-06
ko04260	Cardiac muscle contraction	35/1245	98/7206	9.82870403132e-06
ko05322	Systemic lupus erythematosus	8/1245	151/7206	1.63106785589e-05
ko04514	Cell adhesion molecules (CAMs)	42/1245	130/7206	2.95875099013e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1245	74/7206	3.12304614929e-05
ko05169	Epstein-Barr virus infection	15/1245	206/7206	3.35249289832e-05
ko04730	Long-term depression	28/1245	78/7206	6.36658514262e-05
ko04141	Protein processing in endoplasmic reticulum	13/1245	184/7206	6.64073498599e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1245	79/7206	7.05350006167e-05
ko04745	Phototransduction - fly	17/1245	38/7206	7.2731006238e-05
ko04010	MAPK signaling pathway	83/1245	321/7206	7.79717336807e-05
ko05162	Measles	6/1245	120/7206	7.82684627043e-05
ko05161	Hepatitis B	12/1245	173/7206	9.32394652667e-05
ko04972	Pancreatic secretion	36/1245	111/7206	0.000108564474963
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1245	79/7206	0.000118996074812
ko04110	Cell cycle	9/1245	145/7206	0.000132056170612
ko04976	Bile secretion	28/1245	80/7206	0.000133807441624
ko05140	Leishmaniasis	2/1245	75/7206	0.000159703681622
ko04064	NF-kappa B signaling pathway	4/1245	96/7206	0.00018243870824
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1245	59/7206	0.000200025700131
ko05205	Proteoglycans in cancer	25/1245	271/7206	0.000206677297626
ko05110	Vibrio cholerae infection	23/1245	63/7206	0.000281600003435
ko05414	Dilated cardiomyopathy	35/1245	112/7206	0.000336690985703
ko04610	Complement and coagulation cascades	3/1245	79/7206	0.000457825003605
ko00480	Glutathione metabolism	1/1245	55/7206	0.000532094497126
ko04146	Peroxisome	4/1245	89/7206	0.000559973219469
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1245	14/7206	0.00087077416934
ko04014	Ras signaling pathway	69/1245	279/7206	0.00120362764139
ko00590	Arachidonic acid metabolism	1/1245	52/7206	0.00127730309938
ko00240	Pyrimidine metabolism	7/1245	110/7206	0.00129745877515
ko04626	Plant-pathogen interaction	9/1245	18/7206	0.00145434999321
ko05166	HTLV-I infection	31/1245	292/7206	0.0015180565209
ko04964	Proximal tubule bicarbonate reclamation	12/1245	29/7206	0.00193547843525
ko04612	Antigen processing and presentation	4/1245	77/7206	0.002292746587
ko03420	Nucleotide excision repair	1/1245	46/7206	0.00279162237479
ko04668	TNF signaling pathway	9/1245	120/7206	0.0031639951977
ko04915	Estrogen signaling pathway	36/1245	131/7206	0.00328869285297
ko01524	Platinum drug resistance	4/1245	76/7206	0.00329161677943
ko04371	Apelin signaling pathway	46/1245	177/7206	0.00330421940805
ko04070	Phosphatidylinositol signaling system	32/1245	112/7206	0.00339015942099
ko04923	Regulation of lipolysis in adipocytes	24/1245	77/7206	0.00341786587408
ko04750	Inflammatory mediator regulation of TRP channels	34/1245	122/7206	0.00343285750761
ko05321	Inflammatory bowel disease (IBD)	2/1245	56/7206	0.00377914265209
ko04072	Phospholipase D signaling pathway	50/1245	197/7206	0.00393303729835
ko05145	Toxoplasmosis	10/1245	126/7206	0.00399716824389
ko03022	Basal transcription factors	1/1245	44/7206	0.0042427603386
ko00071	Fatty acid degradation	1/1245	45/7206	0.0044474100729
ko00310	Lysine degradation	4/1245	73/7206	0.00463269985558
ko00330	Arginine and proline metabolism	3/1245	61/7206	0.00618345767304
ko04622	RIG-I-like receptor signaling pathway	3/1245	62/7206	0.0062178263937
ko04658	Th1 and Th2 cell differentiation	7/1245	96/7206	0.00632167513514
ko05133	Pertussis	6/1245	87/7206	0.00656096647467
ko04214	Apoptosis - fly	4/1245	72/7206	0.00684378720513
ko05418	Fluid shear stress and atherosclerosis	17/1245	173/7206	0.00780161884363
ko04630	Jak-STAT signaling pathway	12/1245	132/7206	0.0102131268743
ko04620	Toll-like receptor signaling pathway	8/1245	100/7206	0.0109444203424
ko05131	Shigellosis	6/1245	82/7206	0.0123610312508
ko03018	RNA degradation	6/1245	84/7206	0.0126230888944
ko04115	p53 signaling pathway	5/1245	74/7206	0.012820657134
ko00630	Glyoxylate and dicarboxylate metabolism	1/1245	38/7206	0.0152922987826
ko03410	Base excision repair	1/1245	38/7206	0.0152922987826
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1245	100/7206	0.0155713406622
ko05144	Malaria	2/1245	45/7206	0.0169692123734
ko00280	Valine, leucine and isoleucine degradation	3/1245	54/7206	0.0180664934989
ko00600	Sphingolipid metabolism	4/1245	63/7206	0.0182161918543
ko04640	Hematopoietic cell lineage	4/1245	64/7206	0.0185838554337
ko05206	MicroRNAs in cancer	19/1245	177/7206	0.020094307538
ko04912	GnRH signaling pathway	31/1245	122/7206	0.0212730423361
ko04657	IL-17 signaling pathway	7/1245	87/7206	0.0214493926886
ko00640	Propanoate metabolism	1/1245	34/7206	0.0215135860967
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1245	182/7206	0.0220642072913
ko00500	Starch and sucrose metabolism	1/1245	35/7206	0.022132272083
ko03320	PPAR signaling pathway	5/1245	69/7206	0.0243403210375
ko05212	Pancreatic cancer	7/1245	83/7206	0.0285112610939
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1245	135/7206	0.0291371573088
ko05132	Salmonella infection	9/1245	98/7206	0.031030369082
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1245	15/7206	0.0320867825139
ko05222	Small cell lung cancer	8/1245	89/7206	0.0344308438267
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1245	40/7206	0.035670511126
ko00380	Tryptophan metabolism	3/1245	50/7206	0.036768489912
ko05215	Prostate cancer	11/1245	111/7206	0.0419563901229
ko04916	Melanogenesis	34/1245	142/7206	0.0427450432649
ko04210	Apoptosis	21/1245	180/7206	0.0454641126028
ko00562	Inositol phosphate metabolism	23/1245	89/7206	0.0466160790588
ko04930	Type II diabetes mellitus	15/1245	54/7206	0.0469195989796
ko04350	TGF-beta signaling pathway	10/1245	103/7206	0.047626052086
ko05320	Autoimmune thyroid disease	1/1245	29/7206	0.0479452444319